Using silver nanoparticle and thiol graphene quantum dots nanocomposite as a substratum to load antibody for detection of hepatitis C virus core antigen: Electrochemical oxidation of riboflavin was used as redox probe

Valipour, Akram; Roushani, Mahmoud

doi:10.1016/j.bios.2016.09.086

Cited by 112 publications

(63 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By taking riboflavin as a redox probe, Valipour et al explored the functions of thiolated graphene quantum dots (GQD-SH) as well as AgNPs as electrode-enhancing agents for determining hepatitis C virus (HCV) in a spiked human serum [281]. AgNPs were loaded on GQDs-SH through the Ag-S bond and subsequently, anti-HCV antibodies were immobilized on the GCE.…”

Section: Voltammetric Gqd-sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

190

View full text Add to dashboard Cite

Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow concentrations of relevant biomarkers, pathogens, toxins and pharmaceuticals in biological matrices. Considering these pathophysiologies, various research works have become necessary to fabricate biosensors for their early diagnosis and treatment, using nanomaterials like quantum dots (QDs). These nanomaterials effectively ameliorate the sensor performance with respect to their reproducibility, selectivity as well as sensitivity. In particular, graphene quantum dots (GQDs), which are ideally graphene fragments of nanometer size, constitute discrete features such as acting as attractive fluorophores and excellent electro-catalysts owing to their photo-stability, water-solubility, biocompatibility, non-toxicity and lucrativeness that make them favorable candidates for a wide range of novel biomedical applications. Herein, we reviewed about 300 biomedical studies reported over the last five years which entail the state of art as well as some pioneering ideas with respect to the prominent role of GQDs, especially in the development of optical, electrochemical and photoelectrochemical biosensors. Additionally, we outline the ideal properties of GQDs, their eclectic methods of synthesis, and the general principle behind several biosensing techniques.

show abstract

Section: Voltammetric Gqd-sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

190

View full text Add to dashboard Cite

show abstract

“…The proposed sensor can detect the target bacteria within 30 min, and hence, it has conceivable clinical application for the diagnosis of several other bacterial infections. In 2017, Valipour and Roushani investigated the use of silver nanoparticles (AgNPs)/thiolated graphene quantum dots (GQD-SH) as GCE-modifying nanocomposites, and riboflavin as redox probe for the label-free quantification of hepatitis C virus core antigen (HCV) [150]. AgNPs were immobilized on -SH groups of GQDs via bonding formation of Ag-S, and, consequently, the anti-HCV molecules were loaded on the surface by chemisorption between AgNPs and -NH2 groups of antibody.…”

Section: Gqd-based Electrochemical Immunosensors For the Detection Ofmentioning

confidence: 99%

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Mansuriya

Altıntaş

2019

Materials

View full text Add to dashboard Cite

In the area of biomedicine, research for designing electrochemical sensors has evolved over the past decade, since it is crucial to selectively quantify biomarkers or pathogens in clinical samples for the efficacious diagnosis and/or treatment of various diseases. To fulfil the demand of rapid, specific, economic, and easy detection of such biomolecules in ultralow amounts, numerous nanomaterials have been explored to effectively enhance the sensitivity, selectivity, and reproducibility of immunosensors. Graphene quantum dots (GQDs) have garnered tremendous attention in immunosensor development, owing to their special attributes such as large surface area, excellent biocompatibility, quantum confinement, edge effects, and abundant sites for chemical modification. Besides these distinct features, GQDs acquire peroxidase (POD)-mimicking electro-catalytic activity, and hence, they can replace horseradish peroxidase (HRP)-based systems to conduct facile, quick, and inexpensive label-free immunoassays. The chief motive of this review article is to summarize and focus on the recent advances in GQD-based electrochemical immunosensors for the early and rapid detection of cancer, cardiovascular disorders, and pathogenic diseases. Moreover, the underlying principles of electrochemical immunosensing techniques are also highlighted. These GQD immunosensors are ubiquitous in biomedical diagnosis and conducive for miniaturization, encouraging low-cost disease diagnostics in developing nations using point-of-care testing (POCT) and similar allusive techniques.

show abstract

“…2, Structure I). Flavins are known to exhibit near-reversible electrochemical behaviour [34] which, by virtue of the intrinsic acidbase functionality of the core structure, will be pH dependent. The key challenge in the proposed design, however, relates to anchoring the redox system to the exposed carbon particles within the composite mesh.…”

Section: Introductionmentioning

confidence: 99%

Design of a smart sensor mesh for the measurement of pH in ostomy applications

et al. 2019

View full text Add to dashboard Cite

A carbon-loaded polyethylene film was modified through a combination of laser ablation and electrochemical anodisation to yield a mechanically flexible yet electroanalytically sensitive mesh. A custom flavin derivative bearing a pendant phenol substituent was electropolymerised onto the substrate, and its electrochemical properties were investigated. The reversible flavin electrochemistry was retained (Ep =-0.374 V vs. Ag/AgCl, pH 7), and the peak position was found to shift by 60 mV/pH over a range covering pH 2.55 to pH 8.12. The stability of the resulting composite has been evaluated, and the analytical applicability towards the voltammetric measurement of pH in human urine was critically assessed.

show abstract

Using silver nanoparticle and thiol graphene quantum dots nanocomposite as a substratum to load antibody for detection of hepatitis C virus core antigen: Electrochemical oxidation of riboflavin was used as redox probe

Cited by 112 publications

References 24 publications

Applications of Graphene Quantum Dots in Biomedical Sensors

Applications of Graphene Quantum Dots in Biomedical Sensors

Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

Design of a smart sensor mesh for the measurement of pH in ostomy applications

Contact Info

Product

Resources

About