Using simulated neuronal cell models for detection of epileptic seizures in foramen ovale and scalp EEG

Schindler, Kaspar; Wiest, Roland; Kollár, Marek; Donati, Filippo

doi:10.1016/s1388-2457(01)00522-3

Cited by 33 publications

(22 citation statements)

References 25 publications

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“…The time points corresponding to ictal onset and offset were identified using a method developed by Schindler et al [18]. The time series was divided into 6 second moving windows with an overlap of 5.75 seconds and the z-score of the time series within each window was obtained in order to normalize the variance of the channels.…”

Section: Methodsmentioning

confidence: 99%

Analysis of epileptogenic network properties during ictal activity

Wilke

Worrell

2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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In the present study, we utilize methods from graph theory to analyze epileptogenic network properties during periods of ictal activity. Using these methods, we analyzed the DTF-based causal information flow in nine seizures recorded from two patients undergoing presurgical monitoring for the treatment of medically intractable epilepsy. From the results, we observed a high degree of correlation between the regions with a high amount of information outflow (termed the outdegree) and the cortical areas identified clinically as the generators of the ictal activity. We furthermore observe a frequency-dependent correlation between the co-localization of these "activated regions" and the clinical foci. These findings suggest that application of network analysis tools to ictal activity could provide clinically useful information concerning these epileptogenic networks.

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Section: Methodsmentioning

confidence: 99%

Analysis of epileptogenic network properties during ictal activity

Wilke

Worrell

2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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“…S i (t) is an appropriate characteristic of epileptiform EEG because it increases for both high amplitude slow, but also low amplitude fast activities, as are typically observed at the onset and during intracranially recorded seizures. 4 In a second step, S i (t) was normalised to …”

Section: Methodsmentioning

confidence: 99%

How generalised are secondarily "generalised" tonic clonic seizures?

Schindler

Leung

Lehnertz

et al. 2007

Journal of Neurology, Neurosurgery & Psychiatry

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In clinical practice, epileptic seizures with focal onset and subsequent generalised motor involvement are referred to as secondarily generalised seizures. The purpose of this study was to investigate the degree of electrophysiological generalisation in seizures that are clinically secondarily generalised. Intracranial EEG recordings of secondarily generalised tonicclonic seizures were visually and quantitatively analysed for the presence of epileptiform activity. In 24 (26%) of 93 seizures recorded from 17 (27%) of 64 patients, intracranial EEG channels were found that never recorded epileptiform activity during secondarily generalised tonic-clonic seizures. Our results demonstrate that seizures that are secondarily generalised clinically are not always generalised electrophysiologically. This may have therapeutic implications.

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“…Up to now, several investigations based on nonlinear time series analysis have been carried out on intracranial and surface EEG data with promising results [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][22][23][24][25][26]. Table 1 summarizes the achievements of seizure prediction methods developed to date.…”

Section: Introductionmentioning

confidence: 99%