Using skin for drug delivery and diagnosis in the critically ill

Liu, Xin; Krüger, Peter; Maibach, Howard I.; Colditz, Paul B.; Roberts, Michael S.

doi:10.1016/j.addr.2014.10.004

Cited by 34 publications

(21 citation statements)

References 135 publications

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“…Skin being a large organ, switching to alternative routes of administration, such as the topical route, can, in principle provides predicable, effective and reliable drug delivery. Topical application allows local drug targeting with minimal systemic effects and is mainly used for delivery of anti-inflammatory, antihistaminic, antibiotics, wound healing and analgesic drugs (Liu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Joshi

Pandey

et al. 2016

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Joshi

Pandey

et al. 2016

Journal of Ethnopharmacology

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“…Transdermal drug delivery has, however, several issues due to the limited permeability of the skin. Given the possibility of skin electroporation, electrical excitation from a smart scaffold would show great promise to achieve transdermal or subcutaneous controlled drug delivery to the underneath vascular system …”

Section: Applications Of Nanocomposite Scaffolds For Controlled Drug mentioning

confidence: 99%

“…Given the possibility of skin electroporation, electrical excitation from a smart scaffold would show great promise to achieve transdermal or subcutaneous controlled drug delivery to the underneath vascular system. [203] Polyelectrolyte-based-hydrogels loaded with drugs and submitted to electric fields have been used for these purposes given their mechanical response (bending/deswelling) upon exposure to an electric field. [204] The efficient pulsatile release of drugs can be efficiently achieved using electrical pulses.…”

Section: Electroresponsive Scaffolds For Transdermal Drug Deliverymentioning

confidence: 99%

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

Mertz

Harlepp

Goetz

et al. 2019

Advanced Therapeutics

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The blossoming development of nanomaterials and polymer science has opened the way toward new biocompatible scaffolds responding remotely to external stimuli (magnetic field, light, electric field). Such smart scaffolds are envisioned as new implantable tissues displaying multiple therapeutic and imaging functionalities. They hold great promises to achieve a controlled delivery of therapeutics for various diseases, or to ensure a stimuli‐induced cellular response for bone, cardiac, or muscle tissue engineering.

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“…Pada penelitian ini pengobatan dengan pasta kulit manggis diberikan secara topikal karena bertujuan mencapai efek lokal, lebih efektif, efek sistemik minimal dan sebagai pengantar obat terutama sebagai anti oksidan dan anti inflamasi pada proses penyembuhan luka. Apabila ekstrak kulit manggis diberikan secara sistemik maka akan membutuhkan dosis yang lebih tinggi agar dapat disekresikan secara substansi pada luka (18) .…”

Section: Metode Penelitianunclassified

Peranan Pasta Kulit Manggis Dalam Pembentukan Jaringan Ikat Kolagen Pada Proses Kesembuhan Ulkus Mukosa Mulut

Sunarjo

Siregar

Supriyana

2019

jkg. jurnal. kesehatan. gigi

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Prevalence of mouth ulcer in patients who visited dental clinic ranged 27%, contributing factors as chemical trauma and infection. Topical medicine available on the market today contained some chemicals might be contraindicated in hipersensitive patient, required an alternative medication of herbal ingredients that had same efficacy, safe and no allergic. Several studies had shown that xanthone contained in rind mangosteen could act as an anti inflammatory, anti bacterial and anti alergic. Aim of this study was to investigate application of rind mangosteen paste towards collagen formation in mouth ulcer healing due to chemical and infection. The experimental research with post test control group design, randomly obtained a total sample of male Wistar rats was 24 and divided into 4 groups @ 6 tails where 2 (two) treatment groups (due to chemical and infection) smeared with mangosteen rind paste and 2 (two) other treatment groups smeared with standard medicine (PVP), then from each group decapitated the 3 rd , 7 th and 10 th day. Observation was carried out macroscopically and microscopically then the data obtained on the 10 th day performed Kruskal Wallis test. The result of this study showed time healing for chemical ulcer was 9 days (standard medicine) and 10 days (mangosteen rind paste) while infectious ulcer was 10 days (standard medicine) and 9 days (mangosteen rind paste). Role of mangosteen rind paste proved significant in formation collagen of infectious ulcer, usage of standar medicine decreased area of collagen formation on 3 rd , 7 th and 10 th day (0,133 mm; 0,083 mm; 0,059 mm) while usage of mangosteen rind paste might increase this collagen formation (0,073 mm; 0,083 mm; 0,115 mm). There was significant difference broad of collagen formation with p value = 0,016. Topical usage of mangosteen rind paste might accelerate mouth ulcer healing and increase formation of collagen in infectious mouth ulcer.

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Using skin for drug delivery and diagnosis in the critically ill

Cited by 34 publications

References 135 publications

Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Systematic investigation of ethanolic extract from Leea macrophylla : Implications in wound healing

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

Peranan Pasta Kulit Manggis Dalam Pembentukan Jaringan Ikat Kolagen Pada Proses Kesembuhan Ulkus Mukosa Mulut

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