2014
DOI: 10.1002/0471250953.bi1505s45
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Using SomaticSniper to Detect Somatic Single Nucleotide Variants

Abstract: Detecting somatic single nucleotide variants (SNVs) is an essential component of cancer research with next‐generation sequencing data. This unit describes how to run the SomaticSniper somatic SNV detector and then filter the output to eliminate most false positives. It also includes support protocols detailing the compilation of the software. Curr. Protoc. Bioinform. 45:15.5.1‐15.5.8. © 2014 by John Wiley & Sons, Inc.

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“…To determine somatic variants, we utilized samtools [24] followed by SomaticSniper using a somatic score ≥40 and mapping quality ≥40 [25,26]. Additional screening against dbSNP was used to remove probable germline variants [27,28].…”
Section: Methodsmentioning
confidence: 99%
“…To determine somatic variants, we utilized samtools [24] followed by SomaticSniper using a somatic score ≥40 and mapping quality ≥40 [25,26]. Additional screening against dbSNP was used to remove probable germline variants [27,28].…”
Section: Methodsmentioning
confidence: 99%