Knowledge of the liquid–gas flow regime is important for the proper control of many industrial processes (e.g., in the mining, nuclear, petrochemical, and environmental industries). The latest publications in this field concern the use of computational intelligence methods for flow structure recognition, which include, for example, expert systems and artificial neural networks. Generally, machine learning methods exploit various characteristics of sensors signals in the value, time, frequency, and time–frequency domain. In this work, the convolutional neural network (CNN) VGG-16 is applied for analysis of histogram images of signals obtained for water–air flow by using gamma-ray absorption. The experiments were carried out on the laboratory hydraulic installation fitted with a radiometric measurement system. The essential part of the hydraulic installation is a horizontal pipeline made of metalplex, 4.5 m long, with an internal diameter of 30 mm. The radiometric measurement set used in the investigation consists of a linear Am-241 radiation source with an energy of 59.5 keV and a scintillation detector with a NaI(Tl) crystal. In this work, four types of water–air flow regimes (plug, slug, bubble, and transitional plug–bubble) were studied. MATLAB 2022a software was used to analyze the measurement signal obtained from the detector. It was found that the CNN network correctly recognizes the flow regime in more than 90% of the cases.