The purpose of the study was to analyze the factors affecting the acceptance and adoption of e-Health applications among African expats in China from the patient’s perspective. This research used extended technology acceptance model (TAM) with the addition of privacy and trust. The survey method with the structured questionnaire was used to collect data from more than 300 African expats in three Tier 1 cities of China. Hypotheses were tested using partial least squares (PLS) method, a structural equation modeling (SEM) based statistical technique. The results show that perceived usefulness, perceived ease of use (PEU), and privacy have significant effects on intention to use (INT) e-Health technologies. Moreover, PEU endorses positive impact on perceived usefulness. The results also revealed that gender was partially associated with the acceptance and use of e-Health technologies. However, surprisingly, trust had an insignificant effect on INT of e-Health. The results of the current research provide the foundation for the development of policies and strategies for the enhancement of e-Health services to African expats in China. Moreover, the acceptance model of current study can be modified easily because of its generic approach for the investigation of adoption of e-Health services among other developing countries’ expats in China.