Abstract. Nitrous oxide (N 2 O) emissions from Australian grain cropping systems are highly variable due to the large variations in soil and climate conditions and management practices under which crops are grown. Agricultural soils contribute 55% of national N 2 O emissions, and therefore mitigation of these emissions is important. In the present study, we explored N 2 O emissions, yield and emissions intensity in a range of management practices in grain crops across eastern Australia with the Agricultural Production Systems sIMulator (APSIM). The model was initially evaluated against experiments conducted at six field sites across major grain-growing regions in eastern Australia. Measured yields for all crops used in the experiments (wheat, barley, sorghum, maize, cotton, canola and chickpea) and seasonal N 2 O emissions were satisfactorily predicted with R 2 = 0.93 and R 2 = 0.91 respectively. As expected, N 2 O emissions and emissions intensity increased with increasing nitrogen (N) fertiliser input, whereas crop yields increased until a yield plateau was reached at a site-and crop-specific N rate. The mitigation potential of splitting N fertiliser application depended on the climate conditions and was found to be relevant only in the southern grain-growing region, where most rainfall occurs during the cropping season. Growing grain legumes in rotation with cereal crops has great potential to reduce mineral N fertiliser requirements and so N 2 O emissions. In general, N management strategies that maximise yields and increase N use efficiency showed the greatest promise for N 2 O mitigation.