Using the Clinical Global Impression scale to assess social communication change in minimally verbal children with autism spectrum disorder

Toolan, Christina; Holbrook, Alison; Schlink, Andrew; Shire, Stephanie; Brady, Nancy C.; Kasari, Connie

doi:10.1002/aur.2638

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…This study evaluated if neuroimaging findings were associated with DSRD clinical response to therapies (antidepressants, antipsychotics, benzodiazepines, ECT, or immunotherapy) commonly used to treat this condition 5,7 . Clinical response was evaluated using validated metrics including the NPI‐Q, 11 BFCRS, 12,13 25FW, 14 and CGI 15 . Clinical response was classified as a greater than 50% improvement in two of four assessment tools at 12 weeks after treatment initiation (compared to baseline, pretreatment score).…”

Section: Methodsmentioning

confidence: 99%

“… 5 , 7 Clinical response was evaluated using validated metrics including the NPI‐Q, 11 BFCRS, 12 , 13 25FW, 14 and CGI. 15 Clinical response was classified as a greater than 50% improvement in two of four assessment tools at 12 weeks after treatment initiation (compared to baseline, pretreatment score). Responses were coded as a binary response or no response.…”

Section: Methodsmentioning

confidence: 99%

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Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder

Santoro,

Khoshnood,

Jafarpour

et al. 2024

Ann Clin Transl Neurol

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ObjectiveTo determine the prevalence of neuroimaging abnormalities in individuals with Down syndrome regression disorder (DSRD) and evaluate if neuroimaging abnormalities were predictive of therapeutic responses.MethodsA multicenter, retrospective, case–control study which reviewed neuroimaging studies of individuals with DSRD and compared them to a control cohort of individuals with Down syndrome (DS) alone was performed. Individuals aged 10–30 years and meeting international consensus criteria for DSRD were included. The presence of T1, T2/FLAIR, and SWI signal abnormalities was reviewed. Response rates to various therapies, including immunotherapy, were evaluated in the presence of neuroimaging abnormalities.ResultsIn total, 74 individuals (35%) had either T2/FLAIR and/or SWI signal abnormality compared to 14 individuals (12%) without DSRD (p < 0.001, 95%CI: 2.18–7.63). T2/FLAIR signal abnormalities were not appreciated more frequently in individuals with DSRD (14%, 30/210) than in the control cohort (9%, 11/119) (p = 0.18, OR: 1.63, 95%CI: 0.79–3.40). SWI signal abnormalities were appreciated at a higher frequency in individuals with DSRD (24%, 51/210) compared to the control cohort (4%, 5/119) (p < 0.001, OR: 7.31, 95%CI: 2.83–18.90). T2/FLAIR signal abnormalities were localized to the frontal (40%, 12/30) and parietal lobes (37%, 11/30). SWI signal abnormalities were predominantly in the bilateral basal ganglia (94%, 49/52). Individuals with DSRD and the presence of T2/FLAIR and/or SWI signal abnormalities were much more likely to respond to immunotherapy (p < 0.001, OR: 8.42. 95%CI: 3.78–18.76) and less likely to respond to benzodiazepines (p = 0.01, OR: 0.45, 95%CI: 0.25–0.83), antipsychotics (p < 0.001, OR: 0.28, 95%CI: 0.11–0.55), or electroconvulsive therapy (p < 0.001, OR: 0.12; 95%CI: 0.02–0.78) compared to individuals without these neuroimaging abnormalities.InterpretationThis study indicates that in individuals diagnosed with DSRD, T2/FLAIR, and SWI signal abnormalities are more common than previously thought and predict response to immunotherapy.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder

Santoro,

Khoshnood,

Jafarpour

et al. 2024

Ann Clin Transl Neurol

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“…Outcome measures used in intervention research commonly rely on caregiver or clinician reports which can be problematic due to the likelihood of systematic measurement error, expectancy bias or placebo effects (Anagnostou et al, 2015 ; Sandbank et al, 2020 ). The Clinical Global Impression (CGI) rating scales (Busner & Targum, 2007 ), one of the most commonly used outcome measures in intervention research (Bolte & Diehl, 2013 ; Toolan et al, 2022 ), is a subjective measure of relative improvement completed by clinicians. In the case of some behavioral interventions, the CGI is completed by the clinician responsible for delivering treatment, in part because this mirrors typical clinical practice.…”

Section: Limitations Of Previously Used Outcome Measures In Intervent...mentioning

confidence: 99%

Extending the Usefulness of the Brief Observation of Social Communication Change (BOSCC): Validating the Phrase Speech and Young Fluent Version

Byrne

Sterrett

Holbrook

et al. 2022

J Autism Dev Disord

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The current study investigated the utility of the Brief Observation of Social Communication Change-Phrase Speech Young Fluent (BOSCC-PSYF) as an outcome measure of treatment response by analyzing the measure’s psychometric properties and initial validity. The BOSCC coding scheme was applied to 345 administrations from 160 participants diagnosed with autism. Participants included individuals of any age with phrase speech, or individuals under the age of 8 years with complex sentences. All were receiving behavioral intervention throughout the study. Test–retest and inter-rater reliability were good for the Early Communication and Social Reciprocity/Language domains, and fair for the Restricted and Repetitive Behavior domain. Significant changes occurred over time in the Early Communication and Social Reciprocity/Language domains, and Core Total scores. The BOSCC-PSYF may provide a low-cost, flexible, and user-friendly outcome measure that reliably measures changes in broad social communicative behaviors in a short period of time. Supplementary Information The online version contains supplementary material available at 10.1007/s10803-022-05877-5.

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Supporting the Conversational Behavior of Adolescents with Autism Spectrum Disorders with Self-Monitoring and a Video-Based Supplement

Ayvazo,

Shmuel,

Bin-Nun

2024

J Autism Dev Disord

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Individuals with autism spectrum disorders (ASD) might demonstrate impairments in initiating and sustaining a conversation and experience conversational challenges such as question-asking and turn-taking. Conversational skills are pivotal for the social functioning of adolescents with ASD. The current investigation aimed to extend the available information on interventions addressing the conversational needs of adolescents with ASD. The research questions were: (a) What is the effect of self-monitoring, supplemented by a video-based model on the conversational skills of adolescent students with ASD? and (b) What is the acceptability of the intervention among the participating adolescents with ASD?. Appropriate conversational behavior of three students with ASD (aged 16–18 years) was assessed using a withdrawal design, during 10-min conversation sessions. Appropriate conversational behavior was defined as a sequence of a turn-taking response (i.e., waiting quietly until the speaker finished talking), followed by a verbal utterance which included (a) making a statement or responding on topic, and/or (b) asking a contextually appropriate “wh”- question. The independent variable consisted of a primary self-monitoring procedure and a daily video-based supplement. Treatment fidelity and treatment acceptability were also assessed. The conversational behavior of all participants consistently improved under the self-monitoring intervention with the video-based supplement. Self-monitoring with a video-based supplement can effectively support the conversational behavior in adolescents with ASD. This information can guide the evaluation and planning of appropriate interventions designed to improve limited conversational behaviors of adolescents with ASD.

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Using the Clinical Global Impression scale to assess social communication change in minimally verbal children with autism spectrum disorder

Cited by 6 publications

References 45 publications

Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder

Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder

Extending the Usefulness of the Brief Observation of Social Communication Change (BOSCC): Validating the Phrase Speech and Young Fluent Version

Supporting the Conversational Behavior of Adolescents with Autism Spectrum Disorders with Self-Monitoring and a Video-Based Supplement

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