The spread of obesity (globesity) has been declared a worldwide epidemic by the World Health Organization (WHO). More than 1 billion adults are overweight and at least 315 million are clinically obese. This epidemic has generated an unlimited array of weight-loss strategies. Obesity is now one of the most important public and clinical problems: "it increases the risk of many health complications such as hypertension, coronary heart disease and type 2 diabetes, needs long-lasting treatment for effective results and involves high public and private costs" (p. 204, (Castelnuovo et al., 2010)).In the past few years, internet, mobile phone or computer based clinical protocols have shown promising long-term effects in the improvement of healthy lifestyle interventions for the treatment of obesity with or without complications (type 2 diabetes, eating disorders, etc.). These technologies (cd-rom software, internet websites, e-mail contacts, sms or mms based systems, telemedicine platforms etc.) have opened potential applications to revolutionize health care in different inpatient and outpatient settings.There is a significant interest in the employment of new technologies and devices in order to obtain better results in weightreduction programs: this literature has grown strongly over recent years (Riva et al., 2001, Riva et al., 2002, Simpson et al., 2002, Jeffery et al., 2003, Riva et al., 2003, Simpson et al., 2003, Castelnuovo et al., 2004, Goulis et al., 2004, Sherwood et al., 2006, Haugen et al., 2007, Joo and Kim, 2007, Wister et al., 2007, Kim and Kim, 2008, Krukowski et al., 2008, Morak et al., 2008, Schiel et al., 2008, Shaikh et al., 2008, McTigue et al., 2009, Park et al., 2009, Castelnuovo, 2010.One of the main aims of the E-BESITY CPEMH special issue is to present new results concerning the use of advanced telehealth approaches. These innovations are designed to bring healthcare to where it is really needed, providing continuity between clinic settings and patients' daily lives. Technology cannot replace medicine but it can improve the efficacy of traditional clinical and healthy lifestyle protocols.According to Scott and Wonderlich (2010), new technologies are continuously changing and providing new opportunities: "One final thought focuses on the ever-changing nature of technology -and therefore technology based interventions. Technology is always in flux; most cutting-edge technologies of today are typically nothing more than tomorrow's outdated and obsolete methods (keep in mind that the sun dial, abacus, and eight-track cassette players were all "cutting edge" at one time). We have seen many of these changes in our work: for example, modems that we once used with PDAs have become obsolete due to the cellular phones and digital phone lines, the Internet has dramatically changed the way telehealth treatments are being delivered, and some of our older PDAs are not compatible with newer computer operating systems. Technologies will inevitably continue to change, and with these changes will come additiona...