In order to solve the problem of low security in the process of direct reporting of traditional infectious diseases, the corresponding network direct report security model is established by wireless communication technology. According to the network structure of infectious diseases, the transmission path of the information of direct report of epidemic situation is determined, and the data of direct report of epidemic situation is obtained by wireless communication technology. On this basis, the security risk level of wireless communication network is divided. This paper analyzes the negative factors that affect network security from hacker attack, high risk vulnerability of software and user information tampering. Combined with the analysis results of multiple security mechanisms of the direct report network of infectious diseases, the quantitative evaluation of network security is realized, that is, the modeling and analysis of the network direct report security of infectious diseases is realized. Compared with traditional security model, it is found that the network direct report security model can reduce the loss and error of infectious disease data, which has a high application value.