The application of certain mathematical–statistical methods can quantitatively identify and extract the abnormal characteristics from the observation data, and the comprehensive analysis of seismic multi-parameters can study and judge the risk of the tectonic regions better than a single parameter. In this study, the machine learning-based detection of seismic multi-parameters using the sliding extreme value relevancy method, based on the earthquake-corresponding relevancy spectrum, was calculated in the tectonic regions in the western Chinese mainland, and the R-value evaluation was completed. Multi-parameter data included the b value, M value (missing earthquakes), ƞ value (the relationship between seismic magnitude and frequency), D value (seismic hazard), Mf value (intensity factor), N value (earthquake frequency), and Rm value (modulation parameter). The temporal results showed that the high-value anomalies appeared before most target earthquakes during the training period. Moreover, some target earthquakes also occurred during the advantageous extrapolation period with high-value anomalies. The spatial results showed that some months before the target earthquakes, there was indeed a significant abnormal enhancement area that appeared near the epicenter, and the anomaly gradually disappeared after the earthquakes. This study demonstrated that machine learning techniques for detecting earthquake anomalies using seismic multi-parameter data were feasible.