Using the Native Afferent Nervous System to Sense Bladder Fullness: State of the Art

Tennyson, Lauren; Tai, Changfeng; Chermansky, Christopher

doi:10.1007/s11884-016-0391-2

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Understanding lower urinary tract (LUT) neurophysiology is important for improved neuromodulation applications, such as a closed-loop bladder neuroprosthesis in which information about the bladder state is used to control and improve stimulation [3]. Historically, the majority of studies examining LUT function have been performed using acute, anesthetized animal preparations.…”

Section: Introductionmentioning

confidence: 99%

Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface

et al. 2017

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Objective Our goal is to develop an interface that integrates chronic monitoring of lower urinary tract (LUT) activity with stimulation of peripheral pathways. Approach Penetrating microelectrodes were implanted in sacral dorsal root ganglia (DRG) of adult male felines. Peripheral electrodes were placed on or in the pudendal nerve, bladder neck and near the external urethral sphincter. Supra-pubic bladder catheters were implanted for saline infusion and pressure monitoring. Electrode and catheter leads were enclosed in an external housing on the back. Neural signals from microelectrodes and bladder pressure of sedated or awake-behaving felines were recorded under various test conditions in weekly sessions. Electrodes were also stimulated to drive activity. Main results LUT single- and multi-unit activity was recorded for 4 to 11 weeks in four felines. As many as 18 unique bladder pressure single-units were identified in each experiment. Some channels consistently recorded bladder afferent activity for up to 41 days, and we tracked individual single-units for up to 23 days continuously. Distension-evoked and stimulation-driven (DRG and pudendal) bladder emptying was observed, during which LUT sensory activity was recorded. Significance This chronic implant animal model allows for behavioral studies of LUT neurophysiology and will allow for continued development of a closed-loop neuroprosthesis for bladder control.

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Section: Introductionmentioning

confidence: 99%

Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface

et al. 2017

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“…There is still uncertainty about how the bladder relays the perception of fullness to the brain. One possibility is that mechanoreceptors and mechanosensitive ion channels within the bladder transmit information about fullness to afferent neurons [52][53][54][55][56]. There is also evidence that urothelial cells, stretched during bladder filling, release ATP to activate purinergic receptors on bladder afferents and relay bladder fullness to the brain [57][58][59].…”

Section: The Bladdermentioning

confidence: 99%

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research

Peterson

Vezina

2022

Toxics

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Lower urinary tract dysfunction (LUTD) is nearly ubiquitous in men of advancing age and exerts substantial physical, mental, social, and financial costs to society. While a large body of research is focused on the molecular, genetic, and epigenetic underpinnings of the disease, little research has been dedicated to the influence of environmental chemicals on disease initiation, progression, or severity. Despite a few recent studies indicating a potential developmental origin of male LUTD linked to chemical exposures in the womb, it remains a grossly understudied endpoint in toxicology research. Therefore, we direct this review to toxicologists who are considering male LUTD as a new aspect of chemical toxicity studies. We focus on the LUTD disease process in men, as well as in the male mouse as a leading research model. To introduce the disease process, we describe the physiology of the male lower urinary tract and the cellular composition of lower urinary tract tissues. We discuss known and suspected mechanisms of male LUTD and examples of environmental chemicals acting through these mechanisms to contribute to LUTD. We also describe mouse models of LUTD and endpoints to diagnose, characterize, and quantify LUTD in men and mice.

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“…Neural electrophysiology research employing penetrating microelectrodes has also played a similar role in answering questions about the peripheral nervous system and the numerous neuromodulation therapies that target its structures. Microelectrode recordings have contributed to the understanding of peripheral neurophysiology [5]- [8] and also provided highresolution signal inputs for exploring machine-learning techniques driving closed-loop stimulation methods [9], [10].…”

Section: Introductionmentioning

confidence: 99%

Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: A computational modeling study

Madden,

Graham,

Lempka

et al. 2023

Preprint

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Microelectrodes serve as a fundamental tool in electrophysiology research throughout the nervous system, providing a means of exploring neural function with a high resolution of neural firing information. We constructed a hybrid computational model using the finite element method and multi-compartment cable models to explore factors that contribute to extracellular voltage waveforms that are produced by sensory pseudounipolar neurons, specifically, smaller A-type neurons, and that are recorded by microelectrodes in dorsal root ganglia. The finite element method model included a dorsal root ganglion, surrounding tissues, and a planar microelectrode array. We built a multi-compartment neuron model with multiple trajectories of the glomerular initial segment found in many A-type sensory neurons. Our model replicated both the somatic intracellular voltage profile of Aδ low-threshold mechanoreceptor neurons and the unique extracellular voltage waveform shapes that are observed in experimental settings. Results from this model indicated that tortuous glomerular initial segment geometries can introduce distinct multiphasic properties into a neuron's recorded waveform. Our model also demonstrated how recording location relative to specific microanatomical components of these neurons, and recording distance from these components, can contribute to additional changes in the multiphasic characteristics and peak-to-peak voltage amplitude of the waveform. This knowledge may provide context for research employing microelectrode recordings of pseudounipolar neurons in sensory ganglia, including functional mapping and closed-loop neuromodulation. Further, our simulations gave insight into the neurophysiology of pseudounipolar neurons by demonstrating how the glomerular initial segment aids in increasing the resistance of the stem axon and mitigating rebounding somatic action potentials.

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Using the Native Afferent Nervous System to Sense Bladder Fullness: State of the Art

Cited by 4 publications

References 16 publications

Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface

Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface

Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research

Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: A computational modeling study

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