BackgroundThis study updates a 2017 review on the effectiveness of digital interventions for reducing alcohol use in the general population.MethodsAn updated systematic search of the MEDLINE database was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses criteria to identify randomized controlled trials (RCTs) published from January 2017 to June 2022 which evaluated the effectiveness of digital interventions compared to no interventions, minimal interventions, and face‐to‐face interventions for reducing alcohol use in the general population and, further, which reported changes in alcohol use (quantity, frequency, quantity per drinking day, heavy episodic drinking (HED), or Alcohol Use Disorders Identification Test (AUDIT) scores). A secondary analysis was performed which analyzed data from RCT of students. The review was not preregistered.ResultsThe search produced 2,224 articles. A total of 80 studies were included in the review, 35 of which were published after the last systematic review. A total of 66, 20, 18, 26, and 9 studies assessed the impact of digital interventions on alcohol quantity, frequency, quantity per drinking day, HED, and AUDIT scores respectively. Individuals randomized to the digital interventions drank 4.12 (95% confidence interval (CI): 2.88, 5.36) fewer grams of alcohol per day, had 0.17 (95% CI 0.06, 0.29) fewer drinking days per week, drank approximately 3.89 (95% CI: 0.40, 7.38) fewer grams of alcohol per drinking day, had 1.11 (95% CI: 0.32, 1.91) fewer HED occasions per month, and had an AUDIT score 3.04 points lower (95% CI: 2.23, 3.85) when compared to individuals randomized to the control condition. Significant reductions in alcohol quantity, frequency, and HED, but not quantity per drinking day, were observed for students.ConclusionsDigital interventions show potential for reducing alcohol use in general populations and could be used widely at the population level to reduce alcohol‐attributable harms.