Using the spirometry to indicate respiratory exercises for elderly with Parkinson’s disease

Guimarães, Daniela; Duarte, Gleison Vieira; Trippo, Karen Valadares; Furtado, Graziella; Oliveira‐Filho, Jamary; Ferraz, Daniel Dominguez

doi:10.1590/1980-5918.031.ao22

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…This may be because reduced PEF values might be explained by respiratory muscle weakness. According to Melo et al [27], the participants classified as an obstructive disorder present a significant reduction in expiratory muscle strength and maximal expiratory flow. It seems that the reduction in respiratory muscle strength may be associated with aging process, neurological impairments, reduction of rib cage movement, and flexed posture [28].…”

Section: Discussionmentioning

confidence: 99%

“…It seems that the reduction in respiratory muscle strength may be associated with aging process, neurological impairments, reduction of rib cage movement, and flexed posture [28]. These characteristics reduce muscle capacity to generate forced flows, contributing to the reduction of pulmonary volumes and respiratory pressures, especially the maximum expiratory pressure, which will worsen with the evolution of the disease [27].…”

Section: Discussionmentioning

confidence: 99%

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Association between Respiratory Function and Motor Function in Different Stages of Parkinson’s Disease

Xi¹,

Bai²,

Li³

et al. 2023

Eur Neurol

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Introduction: Respiratory dysfunction in patients with Parkinson’s disease (PD) could present in the early stage and worsen in the late stages. These changes could be a factor affecting the ability of daily living and quality of life of patients with PD. The primary objective of this study was to assess the respiratory function and its association with motor function in patients with different stages of PD. Methods: This was a cross-sectional study conducted at the Huashan Hospital of Fudan University in Shanghai, China. The study included 65 patients diagnosed with PD (the Hoehn & Yahr scale between 1 and 4) and 20 healthy individuals of similar age, gender, weight and height. The ventilatory function was assessed using the spirometry. Motor function was evaluated using subscale III of the United Parkinson’s disease rating scale (UPDRS-III). After confirming the normality of data distribution, we performed one-way ANOVA with a Tukey’s post-hoc test. Results: Compared with the healthy individuals, there was no statistical significance in forced vital capacity (FVC), forced expiratory volume in 1s (FEV1) and forced expiratory volume in 1s/forced vital capacity (FEV1/FVC) in the H&Y 1 group and H&Y 2 group (P>0.05); but reduced peak expiratory flow (PEF) in the H&Y 2 group (P=0.002). Reduced FVC、FEV1 and PEF was seen in the H&Y3 group (P=0.002, P=0.001 and P=0.0001, respectively). Reduced FVC、FEV1、PEF and FEF25-75% was seen in the H&Y4 group (P=0.001, P=0.0001, P=0.0001 and P=0.025, respectively). The correlation analysis revealed that there was a significant negative correlation between FVC and UPDRS-III scores (r=-0.248, P=0.046), disease duration (r=-0.276, P=0.026), H&Y scale (r=-0.415, P=0.001). FEV1 was negatively correlated with UPDRS-III scores (r=-0.277, P=0.025), disease duration (r=-0.291, P=0.019), H&Y scale (r=-0.434, P=0.0001). FEF25%-75% was negatively correlated with disease duration (r=-0.247, P=0.047), H&Y scale (r=-0.278, P=0.025). Conclusion: Our findings revealed that respiratory impairment is present in moderate and advanced PD patients, and directly related to the severity of the disease. It is important to conduct respiratory function test in the clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between Respiratory Function and Motor Function in Different Stages of Parkinson’s Disease

Xi¹,

Bai²,

Li³

et al. 2023

Eur Neurol

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“…To date ,quitea few genes have been detected as hereditary causes of hereditary PD (dominantly inherited SNCA and LRRK2 alterations, as well as recessive Parkin, PINK1, and ATP13A2 polymorphisms). New Parkinson's disease genes were found, including VPS35 and CHCHD2, which emphasise the significance of mitochondrial function in the disease pathogenesis 42 . Various other factors related to mitochondrial malfunctioning responsible for PD are mentioned in Table 1.…”

Section: Genetic Mutations In Mitochondriamentioning

confidence: 97%

Potential applications of mitochondrial therapy with a focus on Parkinson's disease and mitochondrial transplantation

Wal,

Vig

et al. 2023

Adv Pharm Bull

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Purpose: Both aging and neurodegenerative illnesses are thought to be influenced by mitochondrial malfunction and free radical formation. Deformities of the energy metabolism, mitochondrial genome polymorphisms, nuclear DNA genetic abnormalities associated with mitochondria, modifications of mitochondrial fusion or fission, variations in shape and size, variations in transit, modified mobility of mitochondria, transcription defects, and the emergence of misfolded proteins associated with mitochondria are all linked to Parkinson's disease. Method: This review is a condensed compilation of data from research that have been published between the years of 2014 and 2022, using search engines like Google Scholar, PubMed, and Scopus. Result: Mitochondrial transplantation is a one-of-a-kind treatment for mitochondrial diseases and deficits in mitochondrial biogenesis. The replacement of malfunctioning mitochondria with transplanted viable mitochondria using innovative methodologies has shown promising outcomes as a cure for Parkinson's, involving tissue sparing coupled with enhanced energy generation and lower oxidative damage. Numerous mitochondria-targeted therapies, including mitochondrial gene therapy, redox therapy, and others, have been investigated for their effectiveness and potency. Conclusion: The development of innovative therapeutics for mitochondria-directed treatments in Parkinson's disease may be aided by optimising mitochondrial dynamics. Many neurological diseases have been studied in animal and cellular models, and it has been found that mitochondrial maintenance can slow the death of neuronal cells. It has been hypothesised that drug therapies for neurodegenerative diseases that focus on mitochondrial dysfunction will help to delay the onset of neuronal dysfunction.

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“…A doença de Parkinson (DP) é considerada uma enfermidade neurodegenerativa que se caracteriza como um distúrbio dos neurônios dopaminérgicos da substância negra do mesencéfalo 1,2 . Dentro do seu quadro sintomático, destacam-se as alterações posturais, temores, rigidez e bradicinesia 3 .…”

Section: Introductionunclassified

Análise da mobilidade toracoabdominal de idosos com doença de parkinson, submetidos ao treinamento funcional, bicicleta estacionária e exergame: um ensaio clínico randomizado

Duarte¹,

Ribeiro²,

Ferraz³

2019

cmbio

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Análise da mobilidade toracoabdominal de idosos com doença de parkinson, submetidos ao treinamento funcional, bicicleta estacionária e exergame: um ensaio clínico randomizado 325 Rev. Ciênc. Méd. Biol., Salvador, v. 18, n. 3, p. 325-329, set./dez. 2019 325 Análise da mobilidade toracoabdominal de idosos com doença de parkinson, submetidos ao treinamento funcional, bicicleta estacionária e exergame: um ensaio clínico randomizado Analysis of the thoracoabdominal mobility of elderly parkinson's disease that have done stationary bicycle, functional training and exergaming: a randomized controlled trial Resumo Introdução: idosos com doença de Parkinson (DP) apresentam mobilidade toracoabdominal reduzida, o que os predispõe a complicações respiratórias, como a pneumonia aspirativa. Objetivo: avaliar a mobilidade toracoabdominal em idosos com doença de Parkinson, antes e após realizarem treino funcional, bicicleta estacionária e exergame. Metodologia: 58 idosos foram randomizados em três grupos: um que realizou treino funcional (GF) n=18, outro que fez bicicleta estacionária (GB) n=20 e o terceiro que realizou o exergame (GE) n=20. A mobilidade foi mensurada pela cirtometria, por avaliador cego, em três níveis: axilar, xifoideano e umbilical, antes e após as intervenções. Resultados: não foram encontradas diferenças estatisticamente significativas no coeficiente de amplitude nos níveis axilar e xifoide e umbilical nos três grupos. No nível umbilical, entretanto, houve um discreto acréscimo, comparando antes e após as intervenções GF de 2,1(4,52) cm para 3,1(4,27) cm; GB de 1,1(3,16) cm para 1,7(4,68) cm e GE de 0,5 (3,29) cm para 1,0 (3,68) cm. Conclusão: os três programas de exercícios propostos não foram eficazes na melhora da mobilidade torácica no nível axilar e xifoide e parecem provocar uma pequena melhora na mobilidade abdominal, no contexto respiratório. Palavras-chave: Idoso. Exercício. Doença de Parkinson. Fisioterapia. AbstractIntroduction: elderly with Parkinson's disease (PD), have reduced thoracoabdominal mobility, which predisposes to respiratory complications such as aspiration pneumonia. Objective: to assess thoracoabdominal mobility in elderly with PD before and after performing functional training, stationary bike and exergaming. Methodology: fifty eight (58) elderly people were randomized into three groups: functional training (GF) n = 18, stationary bike (GB) n = 20 and exergaming (GE) n = 20. Mobility was measured by cirtometry, by blind assessor, in three levels: axillary, xiphoid and umbilical; before and after the interventions. Results: no statistically significant differences were found in the amplitude coefficient at axillary and xiphoid and umbilical levels in the three groups. At the umbilical level, however, there was a slight increase comparing before and after GF interventions from 2.1 (4.52) cm to 3.1 (4.27) cm; GB of 1.1 (3.16) cm to 1.7 (4.68) cm and GE of 0.5 (3.29) cm to 1.0 (3.68) cm. Conclusion: the three exercise programs proposed were not effective in improving axillary and xiph...

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Using the spirometry to indicate respiratory exercises for elderly with Parkinson’s disease

Cited by 6 publications

References 19 publications

Association between Respiratory Function and Motor Function in Different Stages of Parkinson’s Disease

Association between Respiratory Function and Motor Function in Different Stages of Parkinson’s Disease

Potential applications of mitochondrial therapy with a focus on Parkinson's disease and mitochondrial transplantation

Análise da mobilidade toracoabdominal de idosos com doença de parkinson, submetidos ao treinamento funcional, bicicleta estacionária e exergame: um ensaio clínico randomizado

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