Background: Predischarge home assessments (PDHA) aim to ensure safe discharge from hospital or rehabilitation. There is insufficient evidence on the effectiveness of PDHA. For adults with any diagnosis, we aimed to determine (1) the effects of PDHA on outcomes associated with the successful return to community living (e.g., Activities of Daily Living falls) and (2) the associated barriers and facilitators to derive recommendations for clinical practice.Methods: We searched Medline, EMBASE, CINAHL, five additional databases and other sources. We included individual and cluster randomized (RCT/cRCT) and controlled clinical trials comparing PDHA versus usual care/other intervention, as well as qualitative/mixed methods studies dealing with PDHA. Critical appraisal was performed according to the Cochrane risk-of-bias tool in quantitative studies and the Critical Appraisal Skills Programme (CASP) for qualitative studies and data extraction. Meta-analysis, thematic synthesis and integrative synthesis were performed.Results: Seven RCTs (n = 1072) and ten qualitative studies (n = 245) met the inclusion criteria. RCTs reported a variety of outcomes (n = 17). There is moderate to very low evidence for missing effects on (instrumental) Activities of Daily Living, quality of life, risk of falling and risk of readmission, mobility and fear of falling. The qualitative studies revealed the following topics related to patient education, patient information, patients’ acceptance of modifications and aids, involvement of patient goals and meaningful activities in functional assessment, as well as relevant social- and diagnosis-related patient conditions in PDHA. Seven implications for interventions were derived from these topics. Six of the included RCTs each addressed at least one and at most three of the seven identified meaningful implications for implementation.Conclusion: There is no evidence from the meta-analysis for the effectiveness of PDHA. Further robust studies are needed to adapt and evaluate PDHA interventions, taking the identified implications from stakeholders’ views into account, and should follow the current recommendations for the development and evaluation of complex interventions.Trial registration: The review was registered and methods were reported on PROSPERO on 18th July 2018 (https://www.crd.york.ac.uk/PROSPERO. CRD42018100636).