Using the zebrafish model system to identify the health effects of pharmaceutical pollutants

Microbial degradation and transformation of PPCPs in aquatic environment: A review

“…Merely a minimal dosage of 5 μg L −1 of diclofenac accumulation on tissues of rainbow trout was observed and experienced negative endocrine impacts. Conversely, zebrafish exposed to a combination of acetaminophen, venlafaxine, carbamazepine, and gemfibrozil at quantities ranging from 0.5 to 10 μg L −1 experienced tissue deterioration, a decrease in embryo creation, as well as a rise in embryo death rates [ 48 ]. Being exposed to endocrine-disrupting substances (pollutants) in aquatic environments has also been linked to hypothalamic-pituitary-gonad (HPG), hypothalamic-pituitary-thyroid (HPT), and hypothalamic-pituitary-adrenal (HPA) modulation, leading to interfering with the functioning as well as functions of different physiological characteristics in certain non-target aquatic vertebrates [ 49 ].…”