Conventional indoor climate design and control approaches are based on static thermal comfort/sensation models that view the building occupants as passive recipients of their thermal environment. Recent advances in wearable sensing technologies and their generated streaming data are providing a unique opportunity to understand the user's behaviour and to predict future needs. Estimation of thermal comfort is a challenging task given the subjectivity of human perception; this subjectivity is reflected in the statistical nature of comfort models, as well as the plethora of comfort models available. Additionally, such models are using not-easily or invasively measured variables (e.g., core temperatures and metabolic rate), which are often not practical and undesirable measurements. The main goal of this paper was to develop dynamic model-based monitoring system of the occupant's thermal state and their thermoregulation responses under two different activity levels. In total, 25 participants were subjected to three different environmental temperatures at two different activity levels. The results have shown that a reduced-ordered (second-order) multi-inputs-single-output discrete-time transfer function (MISO-DTF), including three input variables (wearables), namely, aural temperature, heart rate, and average skin heat-flux, is best to estimate the individual's metabolic rate (non-wearable) with a mean absolute percentage error of 8.7%. A general classification model based on a least squares support vector machine (LS-SVM) technique is developed to predict the individual's thermal sensation. For a seven-class classification problem, the results have shown that the overall model accuracy of the developed classifier is 76% with an F1-score value of 84%. The developed LS-SVM classification model for prediction of occupant's thermal sensation can be integrated in the heating, ventilation and air conditioning (HVAC) system to provide an occupant thermal state-based climate controller. In this paper, we introduced an adaptive occupant-based HVAC predictive controller using the developed LS-SVM predictive classification model. Processes 2019, 7, 720 2 of 15Human thermal sensation mainly depends on the human body temperature (core body temperature), which is a function of sets of comfort factors [4,5]. These comfort factors include indoor environmental factors, namely the mean air temperature around the body, relative air velocity around the body, humidity, and the mean radiant temperature to the body [5]. Additionally, some personal (individual-related) factors, namely, metabolic rate or internal heat production in the body, which vary with the activity level and clothing thermal-physical properties (such as clothing insulation and vapour clothing resistance), are included. It should be mentioned that the individual thermal perception is deepening, as well, on psychological factors, including naturalness (an environment where the people tolerate wide changes of the physical environment), expectations and short/long-term expe...