Background: Migrant and seasonal farm workers are at increased risk for occupational fatalities and injuries. However, there is limited evidence about the risk of occupational injury in those who move within the country to take up work in Ethiopia, although in recent years such employment-related geographical mobility is receiving increasing attention. Therefore, this study aimed to investigate work-related injuries, illnesses and the associated risk factors among seasonal and migrant farm workers in Ethiopia.Methods: Community-based cross-sectional study design was employed from October to November 2019 among seasonal and migrant farm workers. The study was carried out in two sites of Amhara regional state, northwest Ethiopia. A cluster sampling technique was used to select 990 study participants. Bivariable and multivariable binary logistic regression analyses were performed using SPSS version 20 to identify predictors. The significance level was obtained at 95% CI and p- value ≤ 0.05.Results: In this study, the period prevalence of work-related injury among seasonal and migrant farm workers was 32.5% (95% CI: 29.7, 35.9). Above half (60.9%) of study participants have shown three or more heat-related illness symptoms. Extreme weakness (56.8%), skin rash (45.1%), headache (40.4%), profuse sweating (42.9%) and fatigue (45.1%) were the commonest heat-related symptoms reported by the seasonal and migrant farm workers. Moreover, the prevalence of work-related stress among seasonal and migrant farm workers was 67.6% (95% CI: 64.6, 70.7). Being unemployed before migration (AOR = 2.22, 95% CI: 1.26, 3.91), working for > 8 h/day (AOR = 1.62, 95% CI: 1.16, 2.27), stress (AOR = 1.38, 95% CI: 1.02, 1.88) and thermal discomfort (AOR = 1.48, 95% CI: 1.09, 1.98) were the significant risk factors for work-related injury.Conclusion: In this study, heat-related illness, work-related injury and stress among seasonal and migrant farm workers in northwest Ethiopia remain a major public health problem. Employment history, average working hours and stress were among the risk factors associated with a work-related injury. Hence, provision of ongoing safety training, personal protective equipments, improving working hours and stress management could be given attention to minimize the problem.