Using Topical Applications of Tamoxifen and a Combination of Phytonutrients Based on Breast MRI to Inhibit Estrogen-Related Proliferation of Human Breast Tissue

Lin, Shoei Loong; Choy, Cheuk-Sing; Chan, Wing P.; Leung, Ting-Kai

doi:10.4172/2153-2435.1000281

Cited by 2 publications

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“…They used Franz cells with artificial skin membranes to show positive transdermal diffusion using animal urine/feces, blood tests, and subcutaneous skin retention for HPLC analysis to study transdermal absorption through topical application. They successfully showed transdermal absorption of topical tamoxifen and phytonutrients, which may aid in preventing breast cancer in daily estrogen and phytoestrogen users (Lin et al 2014). Isabelle Le Ray et al, (2012) 80 have observed that women with estrogen-positive breast cancers receive endocrine treatment such as tamoxifen and aromatase inhibitors (AI) for 5-10 years.…”

Section: Chemotherapy In Breast Cancer Usingmentioning

confidence: 99%

“…Nanoparticles should be used as a controlled release mechanism in cancer treatment to reduce the occurrence of multiple side effects. As a result, this research aimed to see how effective tamoxifenand a methotrexate-loaded transdermal patch was at preventing breast cancer 67 . Buddhade Layek et al, (2010) 95 have used the soyaphosphatidylcholine (SPC), cholesterol (CH), and span 20 as key ingredients and developed a safe sustained release liposomal drug delivery mechanism for tamoxifen citrate (TC).…”

Section: Anti-cancer Drugs In Transdermal Patch: Ajazmentioning

confidence: 99%

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2022

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Cancer refers to a group of diseases characterized by abnormal, unchecked cell growth that spreads to other body parts. Breast, liver, colorectal, kidney, stomach, lungs, and cervical cancer are the most common tumours, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percent of the cases). Surgery, chemotherapy, and other traditional medical methods have several negative side effects, including extreme inflammation and discomfort. As a result, transdermal delivery of the anticancer drug transdermal patch may be beneficial for treating multiple breast cancers via the skin. Transdermal drug penetration using various methods, such as nanocarriers, tactile penetration enhancing tools, chemical penetration enhancers, and newer innovations, such as gels, dendrimers, needle-free injection jets and so on, results in increased patient compliance, scar elimination, and economic benefit. Topical antineoplastic drug delivery is a popular option for increasing site-specific delivery, mitigating side effects, and enhancing therapeutic effects. This study aims to discuss the transdermal delivery of anticancer agents via the skin, which can open up a new frontier in cancer care using nanocarriers. INTRODUCTION:Cancer: Cancer is a broad term for a group of diseases characterized by uncontrolled cell growth that spreads throughout the body. The most common cancers are lung, liver, colorectal, prostate, thyroid, breast, and cervical cancers, with skin cancer (excluding melanoma) being the least common (contributing up to 40 percentage of the cases). Surgery and chemotherapy, for example, have many unpleasant side effects, including severe inflammation and discomfort. New transdermal procedures and methods have been established by QUICK RESPONSE CODE

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Section: Chemotherapy In Breast Cancer Usingmentioning

confidence: 99%

Section: Anti-cancer Drugs In Transdermal Patch: Ajazmentioning

confidence: 99%

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2022

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Inhibition of breast cancer with transdermal tamoxifen-encapsulated lipoplex

Lin

Chen

et al. 2016

J Nanobiotechnol

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BackgroundTamoxifen is currently used for the treatment of both early and advanced estrogen receptor (ER) positive breast cancer in pre- and post-menopausal women. However, using tamoxifen routinely to inhibit endogenous or exogenous estrogen effects is occasionally difficult because of its potential side effects.ObjectivesThe aim of this study is to design a local drug delivery system to encapsulate tamoxifen for observing their efficacy of skin penetration, drug accumulation and cancer therapy.MethodsA cationic liposome-PEG-PEI complex (LPPC) was used as a carrier for the encapsulation of tamoxifen and forming ‘LPPC/TAM’ for transdermal release. The cytotoxicity of LPPC/TAM was analyzed by MTT. The skin penetration, tumor growth inhibition and organ damages were measured in xenograft mice following transdermal treatment.ResultsLPPC/TAM had an average size less than 270 nm and a zeta-potential of approximately 40 mV. LPPC/TAM displayed dramatically increased the cytotoxic activity in all breast cancer cells, especially in ER-positive breast cancer cells. In vivo, LPPC drug delivery helped the fluorescent dye penetrating across the skim and accumulating rapidly in tumor area. Administration of LPPC/TAM by transdermal route inhibited about 86 % of tumor growth in mice bearing BT474 tumors. This local treatment of LPPC/TAM did not injury skin and any organs.ConclusionLPPC-delivery system provided a better skin penetration and drug accumulation and therapeutic efficacy. Therefore, LPPC/TAM drug delivery maybe a useful transdermal tool of drugs utilization for breast cancer therapy.

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Using Topical Applications of Tamoxifen and a Combination of Phytonutrients Based on Breast MRI to Inhibit Estrogen-Related Proliferation of Human Breast Tissue

Cited by 2 publications

References 40 publications

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Inhibition of breast cancer with transdermal tamoxifen-encapsulated lipoplex

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