Using Varronia curassavica (Cordiaceae) essential oil for the biocontrol of Phytomonas serpens

Silva, Kleiton Paulo; Santos, Tamiris Aparecida de Carvalho; Moutinho, Brenda Leite; Silva, Rafael Salomão da; Pinto, Vanderson dos Santos; Blank, Arie Fitzgerald; Corrêa, Cristiane Bani; Scher, Ricardo; Fernandes, Roberta Pereira Miranda

doi:10.1016/j.indcrop.2019.111523

Cited by 12 publications

(9 citation statements)

References 37 publications

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“…Even so, EOs from other plant families have been found to have anti- Phytomonas activity. EOs from Varronia curassavica genotypes have antiprotozoal activity against Phytomonas serpens causing alterations in the permeabilization of the cytoplasmic membrane [ 33 ]. Lantana camara EOs, extracted at different harvesting times, displayed trypanocidal activity on P. serpens [ 34 ], and EOs from Hyssopus officinalis showed antiprotozoal activity on T. cruzi and P. davidi [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

et al. 2023

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Kinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as Leishmania, that cause disease in humans and animals, and Phytomonas, that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments. In the present work, the antiparasitic activity on Leishmania infantum and Phytomonas davidi of 23 essential oils (EOs) from plants of the Lamiaceae and Asteraceae families, extracted by hydrodistillation (HD) at laboratory scale and steam distillation (SD) in a pilot plant, were evaluated. The chemical compositions of the EOs were determined by gas chromatography-mass spectrometry. Additionally, the cytotoxic activity on mammalian cells of the major components from the most active EOs was evaluated, and their anti-Phytomonas and anti-Leishmania effects analyzed. L. infantum was more sensitive to the EOs than P. davidi. The EOs with the best anti-kinetoplastid activity were S. montana, T. vulgaris, M. suaveolens, and L. luisieri. Steam distillation increased the linalyl acetate, β-caryophyllene, and trans-α-necrodyl acetate contents of the EOs, and decreased the amount of borneol and 1,8 cineol. The major active components of the EOs were tested, with thymol being the strongest anti-Phytomonas compound followed by carvacrol. Our study identified potential treatments against kinetoplastids.

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Section: Discussionmentioning

confidence: 99%

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

et al. 2023

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“…For instance, Acheflan®, a topical herbal medicine, was developed by Ache Laboratory using the essential oil extracted from the leaves of this species (Ventrella & Marinho, 2008;Queiroz, 2009). Other studies have revealed that the aqueous extract or the essential oil of V. curassavica has antifungal (Nizio et al, 2015), antiprotozoal (Silva et al, 2019) and insecticidal (Oliveira et al, 2019) activities. The toxicity to the Aedes aegypti mosquito larvae (Santos et al, 2006) and inhibitory activity against gram-positive bacteria were also observed (Meccia et al, 2009;Michielin et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The major compounds observed in the essential oil of V. curassavica are the monoterpenes δ-3-carene, α-pinene, β-pinene, sabinene, and the sesquiterpenes aristolene, allo-aromadendrene, bicyclogermacrene, β-bourbonene, α-cadinol, (E)caryophyllene, ar-curcumene, β-elemene, δ-elemene, α-humulene, γ-muurolene, β-sesquiphellandrene, shyobunol, α-turmerone, β-turmerone, and arturmerone (Queiroz et al, 2016;Marques et al, 2019;Silva et al, 2019). The sesquiterpenes αhumulene and (E)-caryophyllene are considered the two chemical markers of V. curassavica (Brandão et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Change in leaf anatomy, physiology, and essential oil of Varronia curassavica Jacq. accessions under two light conditions

Arrigoni-Blank¹,

Silva²,

Góis³

et al. 2022

BLACPMA

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The aim of this study was to evaluate the effect of light on anatomy, physiology and essential oil content and composition of Varronia curassavica. They were analysed two light conditions (full sunlight and protected environment with 50% shade screen) and five accessions (VCUR-101, VCUR-102, VCUR-201, VCUR-302, VCUR-802). V. curassavicacultivated in full sun presented a greater development of the leaf blade and palisade parenchyma thickness for all accessions. Chlorophyll levels did not differ according to the two light environments. The leaf area was larger in the protected environment. The essential oil yield of the accessions ranged from 0.26 to 0.87 mL/plant in full sun and from 0.34 to 0.53 mL/plant in the protected environment. The composition of the essential oil was influenced by the light and the accession. All accessions presented (E)-caryophyllene and α-humulene. The influence of light on the evaluated variables is genotype dependent.

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“…Hence, the chemical composition must be somewhat constant and predictable for quality assurance of the final product for pharmaceutical purposes. All reports characterized individual samples of V. curassavica using 1D-GC-based methods [44,45]. The seasonal effect of essential oil composition was explored using GC-MS [46][47][48], but without taking into consideration the contribution of plant genotype [48,49].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling of Varronia curassavica Jacq. Terpenoids by Flow Modulated Two-Dimensional Gas Chromatography Coupled to Mass Spectrometry

2020

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In this study, a metabolomic approach was used to investigate the effect of seasonality on the chemical composition and yield of anti-inflammatory active principle, α-humulene, in the essential oil of three genotypes of Varronia curassavica Jacq. (Syn. Cordia verbenaceae). The essential oils were extracted by hydrodistillation and analyzed by comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GC×GC-MS). The GC×GC approach a three-fold improvement in qualitative analysis (48 compounds were identified by GC-MS versus 135 by GC×GC-MS). The improved resolving power of GC×GC resolved important coelutions and enabled the detection of unusual substances in V. curassavica essential oil. The chromatographic data was analyzed by using peak table-based chemometrics, namely, principal component analysis (PCA) and hierarchical cluster analysis (HCA). The metabolic study showed that seasonality has a significant effect on the chemical composition. The α-humulene content was affected by genotype and season. Spring and summer were the best harvest seasons for the yield of the active ingredient, found in higher concentrations in the VC2 genotype. The proposed metabolomic workflow was successfully applied to terpene analysis found in V. curassavica essential oil, and such results have broadened our understanding of the influence of seasonal factors on the specialized metabolism of the species.

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Using Varronia curassavica (Cordiaceae) essential oil for the biocontrol of Phytomonas serpens

Cited by 12 publications

References 37 publications

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

Change in leaf anatomy, physiology, and essential oil of Varronia curassavica Jacq. accessions under two light conditions

Metabolic Profiling of Varronia curassavica Jacq. Terpenoids by Flow Modulated Two-Dimensional Gas Chromatography Coupled to Mass Spectrometry

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