Uso de adesivos teciduais em cirurgia digestiva

Soares-Junior, Cleber; Gomes, Camila Couto; Peixoto, Rodrigo de Oliveira; Gomes, Carlos Augusto; Souza, Cláudio de

doi:10.1590/s0102-67202010000300011

Cited by 3 publications

(2 citation statements)

References 27 publications

(73 reference statements)

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“…Os estudos sobre os adesivos de fibrina e suas aplicações nas anastomoses intestinais datam do início do século XX, com mais ênfase a partir dos anos 1970. 8 É controverso o exato mecanismo de ação dos adesivos de fibrina sobre a cicatrização intestinal, sendo descritos efeitos positivos como a produção de hemostasia local, o estímulo ao fluxo de macrófagos com a produção de fatores que favorecem a angiogênese, a proliferação de fibroblastos e a produção de colágeno. 6,9-11, O uso isolado dos adesivos de fibrina como método de confecção de anastomoses intestinais tem sido restrito a estudos experimentais.…”

Section: Discussionunclassified

The use of fibrin adhesive as an adjuvant factor in the healing of intestinal anastomoses in rats

Borsato¹,

Borsato²,

Souza³

2015

Revista Médica De Minas Gerais

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Introdução: a cicatrização de anastomoses intestinais é objetivo de vários estudos que visam prevenir a ocorrência de fístulas e peritonite fecal que aumentam a morbimortalidade. Objetivo: foram estudados os efeitos do adesivo de fibrina utilizado como fator adjuvante na cicatrização de anastomoses intestinais. Materiais e métodos: 20 ratos Wistar, machos adultos, com peso entre 200 e 300 g foram distribuídos em dois grupos com 10 animais cada. Os animais do grupo I (controle) foram submetidos à secção transversa do cólon a 4 cm distais ao ceco, seguida de anastomose terminoterminal com pontos separados. Nos animais do grupo II foi realizado reforço da anastomose com adesivo de fibrina. A reoperação, em todos os grupos, ocorreu 72 horas após essa intervenção, sendo ressecado o segmento intestinal que continha a anastomose. Foram realizados testes de pressão de ruptura e exames histológicos para avaliação da cicatrização. Resultados: os valores de pressão de ruptura foram significativamente maiores nos animais do grupo II em relação ao grupo-controle (p <0,05). A análise histológica de fragmentos da anastomose corados pela hematoxilina-eosina não mostrou alterações significativas entre os dois grupos. A análise histológica da densitometria de colágeno não mostrou diferenças entre os grupos. Conclusão: o uso do adesivo de fibrina usado como reforço de anastomose intestinal atuou como selante, aumentando a força de pressão de ruptura, porém não foram encontradas alterações histológicas relativas ao processo de cicatrização.

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Section: Discussionunclassified

The use of fibrin adhesive as an adjuvant factor in the healing of intestinal anastomoses in rats

Borsato¹,

Borsato²,

Souza³

2015

Revista Médica De Minas Gerais

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“…However, surgical closure of the rectal wall is challenging. Rectal wall healing is poor compared to other organs due to reduced collagen content and more collagenase-producing bacteria and other factors such as contamination by microorganisms, friction and difficulty in local immobilization may delay healing (Soares et al, 2010). Tight suturing can impair tissue perfusion and oxygenation, hindering rectal healing (Irkorucu et al, 2009).…”

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confidence: 99%

Evaluation of two liver biopsy and rectal sealing techniques in dog cadavers undergoing Natural Orifices Transluminal Endoscopic Surgery (NOTES) by transrectal access

Trindade-Gerardi,

Cima,

Gerardi

et al. 2024

Sem. Ci. Agr.

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The aim of this study was to evaluate two liver biopsy techniques by transrectal Natural Orifice Transluminal Endoscopic Surgery (NOTES) and compare tensiometric parameters of rectal sealing using 2-octyl cyanoacrylate glue or conventional rectal sutures in a dog cadaver model. In sixteen dog cadavers two liver biopsy techniques were performed via transrectal NOTES using either polypectomy diathermy forceps or endoscopic oval biopsy forceps. The cadavers were divided into two groups: Glue Group (GG) where rectal sealing was performed with 2-octyl cyanoacrylate glue and Suture Group (SG) with the rectal defect sealed with simple continuous extracorporeal 3-0 polydioxanone sutures. The rupture pressure of the seals was measured on a rectal burst test. The diathermy polypectomy endoscopic forceps biopsy technique was significantly faster (p<0.001) and provided larger diameter samples. Rectal sealing was significantly faster (p<0.001) in the GG. There was no difference between the two groups with regard to rupture pressure (258.5 mmHg) with air insufflation. Using endoscopic oval biopsy forceps, biopsy samples can only be collected from the surface of the liver, whereas polypectomy forceps with a diathermy loop can be used to collect samples from the tip of the hepatic lobe. There was no difference in rectal rupture pressure in the burst test between the cadavers where sealing was performed with rectal sutures and those where cyanoacrylate adhesive was used.

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Evaluation of tensile strength of tissue adhesives made of fibrin and cyanoacrylate used as reinforcement of colon suture in “ex vivo” swine

Sousa

Paula

Marchi

et al. 2018

Journal of Coloproctology

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Aim To evaluate rupture pressures of tissue adhesives of cyanoacrylate (Omnex®) and fibrin (Evicel®), used as reinforcement in colonic suture from “ex vivo” swine. Methods Surgical procedures were performed in the Surgical Technique Laboratory. From a division in segments of 10 cm of descending colon and sigmoid colon from three “ex vivo” female swine, Landrace breed, which were resected in less than six hours after the slaughter time, 30 segments were selected, 10 of each animal. They were stored in saline solution 0.9% at 36 °C, being randomly allocated in three groups (Control, Evicel and Omnex), each one containing 10 segments. Results The lower and higher pressure values found in the groups Control, Evicel and Omnex were 36 mmHg and 41 mmHg, 70 mmHg and 90 mmHg, 90 mmHg and 120 mmHg, respectively. Containing statistical significance (p-value <0.0001) concerning the 2 to 2 comparisons (Control, Evicel and Omnex) with 95% trusting rate based on the application of the Turkey Method. Conclusion One concludes that the use of tissue adhesives in anastomoses colonic in an experimental animal model of “ex vivo” swine increased the anastomoses rupture pressures. Among the tested adhesives, cyanoacrylate presented higher rupture pressure in relation to fibrin adhesive.

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Uso de adesivos teciduais em cirurgia digestiva

Cited by 3 publications

References 27 publications

The use of fibrin adhesive as an adjuvant factor in the healing of intestinal anastomoses in rats

The use of fibrin adhesive as an adjuvant factor in the healing of intestinal anastomoses in rats

Evaluation of two liver biopsy and rectal sealing techniques in dog cadavers undergoing Natural Orifices Transluminal Endoscopic Surgery (NOTES) by transrectal access

Evaluation of tensile strength of tissue adhesives made of fibrin and cyanoacrylate used as reinforcement of colon suture in “ex vivo” swine

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