Uso De Melatonina Na Cicatrização De Feridas: Uma Revisão

Silva, Jaiurte Gomes Martins da; Melo, Ismaela Maria Ferreira de; Alves, Érique Ricardo; Araújo, Ana Cláudia Carvalho de; Teixeira, Valéria Wanderley; Teixeira, Álvaro Aguiar Coelho

doi:10.29327/213319.22.6-14

TeS

2022

DOI: 10.29327/213319.22.6-14

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Uso De Melatonina Na Cicatrização De Feridas: Uma Revisão

Jaiurte Gomes Martins da Silva¹,

Ismaela Maria Ferreira de Melo²,

Érique Ricardo Alves³

et al.

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2024

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Melatonin and Bacterial Cellulose Regulate the Expression of Inflammatory Cytokines, VEGF, PCNA, and Collagen in Cutaneous Wound Healing in Diabetic Rats

da Silva,

de Melo,

Alves

et al. 2024

Polymers

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The poor healing of diabetic wounds is characterized by prolonged inflammation and decreased collagen deposition. Diabetic patients exhibit changes in the plasma concentrations of pro-inflammatory cytokines, and the role of specific dressings may have an impact on healing. This study aims to evaluate the effects of a combined treatment comprising a bacterial cellulose dressing and melatonin application on the regulation and expression of inflammatory cytokines, VEGF, PCNA, and collagen in the healing of cutaneous wounds of diabetic rats. Pro-inflammatory cytokines, including IL-6, TNF-α, and VEGF, along with PCNA and type I and III collagen, were evaluated after 14 days. Immunohistochemistry showed decreased levels of IL-6, TNF-α, and VEGF, along with an increased expression of PCNA and type I collagen, in the groups treated exclusively with melatonin and bacterial cellulose associated with melatonin compared to the control and the commercial healing agent. It was concluded that treating the skin lesions of diabetic animals supplemented with melatonin using a bacterial cellulose-based dressing has positive effects in regulating the expression of inflammatory cytokines, vascular endothelial growth factor, and collagen, showing that this association could be a viable therapy approach in wound healing.

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Melatonin and Bacterial Cellulose Regulate the Expression of Inflammatory Cytokines, VEGF, PCNA, and Collagen in Cutaneous Wound Healing in Diabetic Rats

da Silva,

de Melo,

Alves

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

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Uso De Melatonina Na Cicatrização De Feridas: Uma Revisão

Cited by 1 publication

References 0 publications

Melatonin and Bacterial Cellulose Regulate the Expression of Inflammatory Cytokines, VEGF, PCNA, and Collagen in Cutaneous Wound Healing in Diabetic Rats

Melatonin and Bacterial Cellulose Regulate the Expression of Inflammatory Cytokines, VEGF, PCNA, and Collagen in Cutaneous Wound Healing in Diabetic Rats

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