Uso do teste ML Flow em escolares diagnosticados com hanseníase no município de Paracatu, Minas Gerais

Ferreira, Isaias Nery; Ferreira, Iris Leda Camargos Silva Nery; Evangelista, Maria do Socorro Nantua; Alvarez, Rosicler Rocha Aiza

doi:10.1590/s0037-86822008000700016

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Spatial targeting has been applied to control various infectious diseases, including leprosy [ 43 – 45 ]. Surveys of school children in high or hyperendemic areas for leprosy has long been advocated as an important strategy for early detection since 1947 [ 46 ], but it is not generally recommended by either national and/or regional control programmes despite some evidence of its efficacy [ 47 – 51 ]. In a recent national student survey, the 2014 Brazilian leprosy campaign concentrated its strategy on evaluating school children of public schools from highly endemic municipalities of the country.…”

Section: Discussionmentioning

confidence: 99%

Spatial epidemiology and serologic cohorts increase the early detection of leprosy

et al. 2015

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BackgroundLeprosy remains an important public health problem in some specific high-burden pockets areas, including the Brazilian Amazon region, where it is hyperendemic among children.MethodsWe selected two elementary public schools located in areas most at risk (cluster of leprosy or hyperendemic census tract) to clinically evaluate their students. We also followed anti-PGL-I seropositive and seronegative individuals and households for 2 years to compare the incidence of leprosy in both groups.ResultsLeprosy was detected in 11 (8.2 %) of 134 school children in high risk areas. The difference in the prevalence was statistically significant (p < .05) compared to our previous findings in randomly selected schools (63/1592; 3.9 %). The 2-year follow-up results showed that 22.3 and 9.4 % of seropositive and seronegative individuals, respectively, developed leprosy (p = .027). The odds of developing overt disease in seropositive people were 2.7 times that of negative people (p < .01), indicating that a follow-up of 10 seropositives has a >90 % probability to detect at least one new case in 2 years. The odds of clinical leprosy were also higher in “positive houses” compared to “negative houses” (p < .05), indicating that a follow-up of ten people living in households with at least one seropositive dweller have a 85 % probability to detect at least one new case in 2 years.ConclusionsTargeted screening involving school-based surveillance planned using results obtained by spatial analysis and targeted household and individual continuous surveillance based on serologic data should be applied to increase the early detection of new leprosy cases.

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Section: Discussionmentioning

confidence: 99%

Spatial epidemiology and serologic cohorts increase the early detection of leprosy

et al. 2015

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“…Some studies show greater seropositivity in males, 18 , 22 while others show it in females. 23 , 24 , 25 It should be recalled that women seek health services more frequently than men, which should encourage greater access to health services and the diagnosis of leprosy. 23 In the analysis, no association was found between sociodemographic data and ML Flow results in household contacts.…”

Section: Discussionmentioning

confidence: 99%

ML Flow serological test: complementary tool in leprosy

Montanha¹,

Nardi²,

Tolentino³

et al. 2023

Anais Brasileiros de Dermatologia

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Molecular and Biotechnological Approaches in the Diagnosis of Leprosy

Lima¹,

Moraes²,

Pinho³

et al. 2019

Hansen's Disease - The Forgotten and Neglected Disease

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Leprosy is a worldwide health problem, which needs the development of new and innovative strategies to be controlled. Early diagnosis of leprosy is an important contribution to reducing the incidence of the disease; thus, the development of biotechnology platforms, which include the mapping of antigens with potential to be used in immunodiagnostic and molecular methods for the detection of Mycobacterium leprae, is an important tool to confirm the clinical diagnostic. Molecular biology and biotechnological methods have been used to assist in the diagnosis of this disease, each one with its advantages and drawbacks. Enzyme-linked immunosorbent assay (ELISA) is the used method for leprosy diagnosis, and it allows the detection of infection-related antigens. Alternatively, due to their versatility to perform the same functions as the protein and non-protein natural antigens, mimetic peptides are considered an important tool. On the other hand, lateral flow assay (LFA) and optical and electrochemical biosensors are rapid and portable methods, capable of performing diagnosis in the field without sample preparation.This chapter presents such techniques, their uses in the diagnosis and detection of M. leprae, as well as the potential for the development of new techniques and strategies that can help to control and understand mycobacteriosis.

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Uso do teste ML Flow em escolares diagnosticados com hanseníase no município de Paracatu, Minas Gerais

Cited by 3 publications

References 7 publications

Spatial epidemiology and serologic cohorts increase the early detection of leprosy

Spatial epidemiology and serologic cohorts increase the early detection of leprosy

ML Flow serological test: complementary tool in leprosy

Molecular and Biotechnological Approaches in the Diagnosis of Leprosy

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