Uso dos anti-inflamatórios não esteroides no controle da dor aguda

Figueiredo, Washington Luís Melo; Alves, Túlio César Azevedo

doi:10.4181/rnc.2015.23.03.1070.05p

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Por outro lado, a inibição da produção de tromboxanos (ex. TXA2) e prostaglandinas envolvidas em funções fisiológicas relevantes (como a PGI2) contribui para a ocorrência de efeitos colaterais (FIGUEIREDO;ALVES, 2015;SANDOVAL et al, 2017;SIMONE et al, 2013). O ácido acetilsalicílico (AAS) foi primeiro AINE comercializado.…”

Section: Farmacologia Da Inflamaçãounclassified

Abordagens Terapêuticas Nas Doenças Inflamatórias: Uma Revisão

Freitas¹,

Mendes²,

Dias³

et al. 2019

Rev. Interfaces

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O processo inflamatório é resultante de uma resposta do organismo a uma lesão tecidual com o objetivo de restaurar a homeostase. Inicialmente ocorre o recrutamento e a ativação de leucócitos, mas com a remoção do agente agressor, a resposta inflamatória é programada para cessar, o que chamamos de resolução da inflamação. O presente estudo consiste em uma revisão de literatura sobre as abordagens terapêuticas nas doenças inflamatórias. Em que teve como critérios de inclusão: estudos em inglês, português ou espanhol, cujo o tema central fossem relacionados ao processo inflamatório ou ao tratamento farmacológico destes processos, assim fazendo parte do presente estudo 47 produções selecionadas. Os anti-inflamatórios não-esteroidais (AINEs) e glicocorticoides (GC) são os fármacos mais utilizados para tratar as doenças inflamatórias. Em geral, estas drogas são eficazes para conter o processo inflamatório, porém possuem muitos efeitos colaterais que trazem riscos aos pacientes. Deste modo, a busca por novos compostos que promovam a resolução da inflamação e tragam menos efeitos colaterais aos pacientes é um desafio para as pesquisas voltadas para a farmacologia da inflamação

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Section: Farmacologia Da Inflamaçãounclassified

Abordagens Terapêuticas Nas Doenças Inflamatórias: Uma Revisão

Freitas¹,

Mendes²,

Dias³

et al. 2019

Rev. Interfaces

View full text Add to dashboard Cite

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“…However, especially in the long term, these drugs are associated with significant adverse effects, including renal impairment, gastritis and gastric ulcers, platelet dysfunction, hemorrhages, dependence, and psychiatric effects such as depression and psychosis. In addition, many of these drugs can cause immunological and nonimmunological hypersensitivity reactions such as anaphylactic reactions, urticaria, and various late cutaneous and organ-specific reactions [7].…”

Section: Introductionmentioning

confidence: 99%

Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings

et al. 2023

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The use of medicinal plants to treat inflammatory conditions and painful processes has attracted the attention of scientists and health professionals due to the evidence that natural products can promote significant therapeutic benefits associated with fewer adverse effects compared to conventional anti-inflammatory drugs. The genus Plectranthus is composed of various plants with pharmacological potential, which are used to treat various diseases in traditional communities worldwide. The present study systematically reviewed Plectranthus species with anti-inflammatory and analgesic potential. To this end, a systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The search was conducted on the following databases: PubMed, ScienceDirect, SciVerse Scopus, and Web of Science. Different combinations of search terms were used to ensure more excellent article coverage. After the selection, a total of 45 articles were included in this review. This study identified twelve Plectranthus species indicated for the treatment of different inflammatory conditions, such as wounds, fever, bronchitis, abscess, asthma, hepatitis, labyrinthitis, tonsillitis, and uterine inflammation. The indications for pain conditions included headache, sore throat, heartburn, menstrual cramp, colic, toothache, stomachache, migraine, chest pain, abdominal pain, local pain, labor pain, and recurring pain. Among the listed species, ten plants were found to be used according to traditional knowledge, although only four of them have been experimentally studied. When assessing the methodological quality of preclinical in vivo assays, most items presented a risk of bias. The SR results revealed the existence of different Plectranthus species used to treat inflammation and pain. The results of this systematic review indicate that Plectranthus species have the potential to be used in the treatment of diseases with an inflammatory component, as well as in the management of pain. However, given the risk of biases, the experimental analysis of these species through preclinical testing is crucial for their safe and effective use.

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Uso dos anti-inflamatórios não esteroides no controle da dor aguda

Cited by 2 publications

References 23 publications

Abordagens Terapêuticas Nas Doenças Inflamatórias: Uma Revisão

Abordagens Terapêuticas Nas Doenças Inflamatórias: Uma Revisão

Plectranthus Species with Anti-Inflammatory and Analgesic Potential: A Systematic Review on Ethnobotanical and Pharmacological Findings

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