Uso racional de antimicrobianos en el departamento de medicina interna de un hospital universitario: resultados de una experiencia piloto

A, Susana Cabrera; Sosa, Leonardo; Arteta, Zaida; Seija, Verónica; Mateos, Soledad; Perna, Abayubá; Firpo, Mariana; Pereira, Gabriela; Lombardo, Gimena; Añón, Ximena; Teliz, Mariela; Danese, Natalia; López, Maynés; Bueno, Jimena; Romero, Claudia; Rozada, Raúl; Antelo, Virginia; Quijano, Ana Laura; Oper, Djalma

doi:10.4067/s0716-10182012000100001

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Global antibiotic consumption increased by 36% from 2000 to 2010 with 76% of this in the BRICS countries, which includes Brazil 6 . There are now signs of increasing controls on antibiotic use in many countries where historically there has been none 7 but the frequency of resistance to key chemotherapeutic antibiotics in pathogens such as Salmonella enterica and Staphylococcus aureus may nevertheless reach 100% of strains in such countries 8–10 . Transmissible resistance to colistin, one of the last resort antibiotics, has also been reported in humans, pigs and meat in China 11 and several other countries.…”

Section: Introductionmentioning

confidence: 99%

Sex pilus specific bacteriophage to drive bacterial population towards antibiotic sensitivity

Colom

Batista

Baig

et al. 2019

Sci Rep

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Antimicrobial resistance (AMR) is now a major global problem largely resulting from the overuse of antibiotics in humans and livestock. In some AMR bacteria, resistance is encoded by conjugative plasmids expressing sex-pili that can readily spread resistance through bacterial populations. The aim of this study was to use sex pilus-specific (SPS) phage to reduce the carriage of AMR plasmids. Here, we demonstrate that SPS phage can kill AMR Escherichia coli and select for AMR plasmid loss in vitro . For the first time, we also demonstrate that SPS phage can both prevent the spread of AMR Salmonella Enteritidis infection in chickens and shift the bacterial population towards antibiotic sensitivity.

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Section: Introductionmentioning

confidence: 99%

Sex pilus specific bacteriophage to drive bacterial population towards antibiotic sensitivity

Colom

Batista

Baig

et al. 2019

Sci Rep

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“…on la aparición de los antimicrobianos (AMs) se ha logrado controlar un gran número de enfermedades infecciosas y disminuir su mortalidad 1,2 ; sin embargo, con el paso de los años su utilización se ha convertido en un problema global; en estudios observacionales, tanto de centros ambulatorios como hospitalarios, cerca de 50% de las prescripciones de AMs son inadecuadas [3][4][5] , ya sea por su uso injustificado, por una elección incorrecta dada la patología o el agente bacteriano o, en algunos casos, una correcta indicación pero inapropiado uso (dosis) 4 . El uso inadecuado de AMs, genera selección de cepas bacterianas resistentes y disminución de alternativas terapéuticas 6 , lo que se asocia a fracasos de tratamientos, extensión de estadías hospitalarias, aumento de morbilidad, mortalidad y costos 7,8 .…”

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“…Debido al dramático aumento de la resistencia bacteriana, las agencias reguladoras proponen ciertas intervenciones: restringir el uso de FQ y cefalosporinas 9,20 reducir los días de tratamiento AMs, reducir los días de tratamiento AMs 21 , cambio a terapia oral precozmente 21 , ajuste de tratamientos según la microbiología en cada institución de salud, uso de otra clases de AMs, como penicilinas y tetraciclinas, entre otros 4,22 .…”

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Cambios en las prescripciones y el consumo de antimicrobianos, luego de la implementación de recomendaciones de uso: experiencia en un hospital universitario

Ávila

Luppi

Gaete

et al. 2019

Rev. chil. infectol.

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Systematic review of antibiotic consumption in acute care hospitals

Bitterman

Hussein

Leibovici

et al. 2016

Clinical Microbiology and Infection

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Antibiotic consumption is an easily quantifiable performance measure in hospitals and might be used for monitoring. We conducted a review of published studies and online surveillance reports reporting on antibiotic consumption in acute care hospitals between the years 1997 and 2013. A pooled estimate of antibiotic consumption was calculated using a random effects meta-analysis of rates with 95% confidence intervals. Heterogeneity was assessed through subgroup analysis and metaregression. Eighty studies, comprising data from 3130 hospitals, met the inclusion criteria. The pooled rate of hospital-wide consumption was 586 (95% confidence interval 540 to 632) defined daily doses (DDD)/1000 hospital days (HD) for all antibacterials. However, consumption rates were highly heterogeneous. Antibacterial consumption was highest in intensive care units, at 1563 DDD/1000 HD (95% confidence interval 1472 to 1653). Hospital-wide antibacterial consumption was higher in Western Europe and in medium-sized, private and university-affiliated hospitals. The methods of data collection were significantly associated with consumption rates, including data sources, dispensing vs. purchase vs. usage data, counting admission and discharge days and inclusion of low-consumption departments. Heterogeneity remained in all subgroup analyses. Major heterogeneity currently precludes defining acceptable antibiotic consumption ranges in acute care hospitals. Guidelines on antibiotic consumption reporting that will account for case mix and a minimal set of hospital characteristics recommending standardized methods for monitoring and reporting are needed.

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Uso racional de antimicrobianos en el departamento de medicina interna de un hospital universitario: resultados de una experiencia piloto

Cited by 4 publications

References 29 publications

Sex pilus specific bacteriophage to drive bacterial population towards antibiotic sensitivity

Sex pilus specific bacteriophage to drive bacterial population towards antibiotic sensitivity

Cambios en las prescripciones y el consumo de antimicrobianos, luego de la implementación de recomendaciones de uso: experiencia en un hospital universitario

Systematic review of antibiotic consumption in acute care hospitals

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