Uso tópico de agente antifibrinolítico na redução do sangramento após revascularização cirúrgica do miocárdio

Abstract

Uso tópico de agente antifibrinolítico na redução do sangramento após revascularização cirúrgica do miocárdioTopical use of antifibrinolytic agent to reduce postoperative bleeding after coronary artery bypass surgery Abstract Objective: Antifibrinolytic agents reduce bleeding after cardiac surgery, but there are adverse effects after their systemic use. These effects are avoided by topical application of antifibrinolytic agents in pericardial cavity. We compared the effects of topically applied epsilon-aminocaproic acid (EACA) and placebo on postoperative bleeding and transfusion requirements after coronary artery bypass surgery.Methods: In this single center prospective, randomized, double-blind trial, 53 patients were randomized into two groups to receive EACA (24 g in 250 ml of saline solution) or placebo (250 ml of saline solution) before sternal closure. Groups were compared according the preoperative and intraoperative variables. Postoperative bleeding, transfusion requirements and hematologic parameters were evaluated.Results

Influência do ácido épsilon aminocapróico no sangramento e na hemotransfusão pós-operatória em cirurgia valvar mitral

“…It was observed a lower bleeding and less need for blood transfusion, statistically significant. Breda et al [18] concluded that the topical use of antifibrinolytic agents in pericardial cavity of epsilonaminocaproic acid had a favorable effect in reducing bleeding in the first 24 hours postoperatively and in the need for blood transfusion after coronary artery bypass grafting when performed.…”