USP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma

Zhang, Qian; Liu, Yuanjie; Li, Jie-Pin; Zeng, Shuhong; Shen, Hui; Han, Mei; Guo, Sheng; Liu, Shenlin; Zou, Xi

doi:10.2147/jir.s362619

Cited by 10 publications

(1 citation statement)

References 41 publications

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“…ALG8 (Uchimura et al, 2005), FAM13A (Liang et al, 2021) and SSPN (Keller et al, 2018) are related to lipid metabolism in cattle and other species. In addition, some genes are involved in immune response and the development of the nervous system, such as CDK19 (Guo et al, 2019; Steinparzer et al, 2019), SFTPD (Lin et al, 2018) and USP35 (Tang et al, 2021; Zhang et al, 2022). KCTD21 (Al‐Mubarak et al, 2017), NEGR1 (Noh et al, 2019) and RBFOX1 (Vuong et al, 2018) have been previously reported to show correlation with neurotransmitter concentration.…”

Section: Resultsmentioning

confidence: 99%

A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province

Lyu,

Guan,

et al. 2023

Animal Genetics

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Over the years, indigenous cattle have not only played an essential role in securing primary food sources but have also been utilized for labor by humans, making them invaluable genetic resources. The Zhaotong cattle, a native Chinese breed from the Yunnan province, possess excellent meat quality and resistance to heat and humidity. Here we used whole genome sequencing data of 104 animals to delve into the population structure, genomic diversity and potential positive selection signals in Zhaotong cattle. The findings of this study demonstrate that the genetic composition of Zhaotong cattle was primarily derived from Chinese indicine cattle and East Asian cattle. The nucleotide diversity of Zhaotong cattle was only lower than that of Chinese indicine cattle, which was much higher than that of other taurine cattle. Genome‐wide selection scans detected a series of positive candidate regions containing multiple key genes related to bone development and metabolism (CA10, GABRG3, GLDN and NOTUM), meat quality traits (ALG8, LINGO2, MYO5B, PRKG1 and GABRB1), immune response (ADA2, BMF, LEF1 and PAK6) and heat resistance (EIF2AK4 and LEF1). In summary, this study supplies essential genetic insights into the genome diversity within Zhaotong cattle and provides a foundational framework for comprehending the genetic basis of indigenous cattle breeds.

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Section: Resultsmentioning

confidence: 99%

A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province

Lyu,

Guan,

et al. 2023

Animal Genetics

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Investigating the synergistic effects of immunotherapy and normalization treatment in modulating tumor microenvironment and enhancing treatment efficacy

Harkos,

Stylianopoulos

2024

Journal of Theoretical Biology

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USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer

et al. 2023

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Ubiquitin-specific-processing proteases 35 (USP35) is an under-characterized deubiquitinase and its role in colorectal cancer (CRC) remains unclear. Here, we focus on delineating the impact of USP35 on CRC cell proliferation and chemo-resistance, as well as the possible regulatory mechanism. By examining the genomic database and clinical samples, we found that USP35 was overexpressed in CRC. Further functional studies showed that enhanced USP35 expression promoted CRC cell proliferation and resistance to oxaliplatin (OXA) and 5-fluorouracil (5-FU), whereas USP35 depletion impeded cell proliferation and sensitized cells to OXA and 5-FU treatments. Then, to explore the possible mechanism underlying USP35-triggered cellular responses, we performed co-immunoprecipitation (co-IP) followed by mass spectrometry (MS) analysis and identified α-L-fucosidase 1 (FUCA1) as a direct deubiquitiation target of USP35. Importantly, we demonstrated that FUCA1 was an essential mediator for USP35-induced cell proliferation and chemo-resistance in vitro and in vivo. Finally, we observed that nucleotide excision repair (NER) components (e.g., XPC, XPA, ERCC1) were up-regulated by USP35-FUCA1 axis, indicating a potential mechanism for USP35-FUCA1-mediated platinum resistance in CRC. Together, our results for the first time explored the role and important mechanism of USP35 in CRC cell proliferation and chemotherapeutic response, providing a rationale for USP35-FUCA1-targeted therapy in CRC.

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USP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma

Cited by 10 publications

References 41 publications

A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province

A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province

Investigating the synergistic effects of immunotherapy and normalization treatment in modulating tumor microenvironment and enhancing treatment efficacy

USP35 promotes cell proliferation and chemotherapeutic resistance through stabilizing FUCA1 in colorectal cancer

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