Usual Interstitial Pneumonia and Chronic Idiopathic Interstitial Pneumonia: Analysis of CT Appearance in 92 Patients

Abstract

UIP has a characteristic appearance that usually facilitates distinction from other types of chronic IIPs at thin-section CT. The most useful finding when differentiating UIP from NSIP was the extent of honeycombing.

Fibrotic idiopathic interstitial pneumonias: HRCT findings that predict mortality

“…In a separate study designed to distinguish UIP from NSIP Akira et al [21] found traction bronchiectasis was significantly more common in UIP (and by extension was likely to be associated with a worse outcome). Conversely, in a third study (n=72), Sumikawa et al [20] did not find traction bronchiectasis scores aided differentiation between fibrotic NSIP and UIP. These studies estimated the severity of traction bronchiectasis using similar methodologies: (1) by counting the number of pulmonary segments in which it was present and (2) by assigning a score according to the anatomical level at which dilatation was identified (peripheral airway dilatation was assigned a lower score than proximal dilatation) [13,20].…”

“…Conversely, in a third study (n=72), Sumikawa et al [20] did not find traction bronchiectasis scores aided differentiation between fibrotic NSIP and UIP. These studies estimated the severity of traction bronchiectasis using similar methodologies: (1) by counting the number of pulmonary segments in which it was present and (2) by assigning a score according to the anatomical level at which dilatation was identified (peripheral airway dilatation was assigned a lower score than proximal dilatation) [13,20]. However, these scoring systems are dependent upon the extent and distribution of fibrosis and may not necessarily reflect the intensity of local architectural distortion.…”

“…In the radiological literature there is conflicting evidence regarding the prognostic significance of traction bronchiectasis in fibrotic IIP [13,20,21]. In one study confined to patients with a histological diagnosis of UIP (n=98), traction bronchiectasis was shown to be a significant predictor of outcome (HR: 1.3, CI 1.20-1.44) [13].…”

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

“…(29)(30)(31)(32)(33)(34) In contrast, extensive honeycombing is much more commonly a manifestation of UIP. (35) The findings described above for NSIP are not specific. Therefore, in the absence of a definable collagen vascular disease or exposure to fibrogenic drugs, surgical lung biopsy is necessary.…”

CT Imaging Phenotypes of Pulmonary Fibrosis in the MUC5B Promoter Site Polymorphism

“…17,19,[23][24][25][26] In our study, the T group more often demonstrated the typical axial distribution of UIP than did the major allele group; this likely led to a higher percentage of UIP and probable UIP scores in these subjects than in those in the G group. We theorize that subjects who carry the minor T allele at the rs35705950 SNP, and then develop pulmonary fibrosis, are more likely to develop the typical imaging manifestations of UIP/IPF.…”