Uterine Angiosarcoma

Abstract

Uterine angiosarcoma is a rare, extremely malignant vascular tumor. Here, we report a case of giant uterine angiosarcoma in a 56-yr-old woman. The tumor was diagnosed as an epithelioid uterine angiosarcoma based on histopathologic findings. The tumor cells showed vascular differentiation; they were positive for the vascular endothelial markers CD31, CD34, and was negative for lymphatic endothelial marker D2-40. In addition, the tumor cells showed overexpression of cell-cycle regulatory protein cyclin D1 and were positive for epithelial-mesenchymal transition marker vimentin. Although it was reported previously that there was breakage in YWHAE, NUTM2A (FAM22A), and NUTM2B (FAM22B) in a case of uterine angiosarcoma, no breakage in these loci was detected by fluorescence in situ hybridization in the present case.

Post-radiation angiosarcoma of the uterine cervix

“…liver, heart), retroperitoneal sites, and radiation-induced disease had poorer outcomes in some series (Young et al, 2010). Five year overall survival for the rare cases of female genital tract angiosarcomas is reported as 27%, slightly lower than those presenting in other anatomic locations (Kruse et al, 2014; Liu et al, 2016). The standard of care is surgical resection +/− adjuvant chemoradiation therapy in the absence of widely metastatic disease, and chemotherapy in metastatic cases.…”

Uterine haemangiosarcoma in a Netherland Dwarf rabbit (Oryctolagus cuniculus Netherland dwarf)

“…Meanwhile, in animals, there have been only two cases in dogs and one case each in a mare, an elephant and a monkey (Landolfi et al., 2021 ; Murakami et al., 2001 ; Segabinazzi et al., 2021 ; Wenzlow et al., 2009 ). Clinical signs reported in human patients and animals with uterine haemangiosarcoma were mostly bleeding from the vulva, anaemia and palpable abdominal masses (Chinczewski et al., 2020 ; Deb et al., 2022 ; Liu et al., 2016 ; Murakami et al., 2001 ; Segabinazzi et al., 2021 ; Wenzlow et al., 2009 ). In the present case, the primary complaint was haemorrhagic discharge from the vulva.…”