Uterine artery Doppler flow studies in obstetric practice

Sciscione, Anthony; Hayes, Edward J.

doi:10.1016/j.ajog.2009.03.027

Cited by 78 publications

(74 citation statements)

References 22 publications

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“…However in our personal experience, the use of Doppler ultrasonography to confirm a suspected cervical lesion is less common, especially in a developing country such as Sri Lanka. In some studies it has been suggested that colour signals may be identified in 100% of cervical cancers [8]. Studies have also suggested that blood flow, as assessed by transvaginal color Doppler, correlated with some tumor characteristics that could lead to prognostication purposes and determination of response to treatment [10].…”

Section: Discussionmentioning

confidence: 99%

“…Pulsatality index is a measure of the variability of blood velocity in a vessel, equal to the difference between the peak systolic and minimum diastolic velocities divided by the mean velocity during the cardiac cycle [8]. It was noted during a through literature survey that there is a significant paucity of studies carried out to determine the use of transvaginal doppler ultrasonography to detect pre-malignant lesions of the cervix.…”

Section: Introductionmentioning

confidence: 99%

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Transvaginal Color Doppler in the Assessment of Cervical Carcinoma and Pre-Cancer: Evidence from a Case Control Study Using Colour Doppler Ultrasonography Pulsatility Index of Uterine Vasculature

Dodampahala¹,

Jayakody²,

Gunathilake³

et al. 2016

ARSci

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Introduction: Transvaginal colour Doppler is a non-invasive ultrasound-based technique that allows an in-vivo assessment of tumor vascularization. Several researches done in the last decade have evaluated the role of this technique in assessing carcinoma of the cervix. However there is a significant paucity of literature linked to pre-malignant lesions of the cervix and its diagnosis based on transvaginal colour doppler and its pulstality index (PI). In this paper we present a case control study conducted to assess the validity of transvaginal colour doppler scan and PI in diagnosing malignant and pre-malignant lesions of the cervix. Methodology: A case control study with a total sample of 57 women was conducted at the Nawaloka Hospital for duration of two years. 19 cases of recently diagnosed patients with cervical carcinoma, using cytobrush and colposcopy guided biopsy, evaluated by a consultant histopathologist, were recruited. Staging was done according to FIGO classification. 40 age-matched patients with histologically confirmed normal cervix were selected as controls and 2 were excluded from the study due to the presence of cervical infection. All cases and controls were subjected to transvaginal colour doppler sonography using a 1.94 (range 1.2 -3.1) and the mean PI value for the controls were 0.805 (range 0.3 -1.5). Neovascularization was markedly seen in the patients with invasive cervical carcinoma with a PI ranging between 1.99 and 3.10. Chi square test results showed a very high statistically significant difference of PI values between cases and controls (p value < 0.0001). An ROC analysis revealed the optimal cut-off value of PI at 1.475 with a sensitivity of 89.5% and a specificity of 93.5%. Conclusion: Transvaginal doppler ultrasonography and PI of the descending cervical branch of the uterine artery and its branch vasculature allow a non-invasive assessment of tumor vascularization in cervical carcinoma and pre-malignancy. PI with a cut off value of 1.475, can be reliably used to detect and screen pre-malignancies and malignancies at a relatively early stage with a sensitivity of 89.5% and a specificity of 93.5% enabling further definitive evaluation, in a routine gynecology trans vaginal ultrasound assessment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transvaginal Color Doppler in the Assessment of Cervical Carcinoma and Pre-Cancer: Evidence from a Case Control Study Using Colour Doppler Ultrasonography Pulsatility Index of Uterine Vasculature

Dodampahala¹,

Jayakody²,

Gunathilake³

et al. 2016

ARSci

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“…The current trend suggests that routine Doppler evaluation does not add anything, so routine screening is not recommended (9,20). Regarding the IUGR cases, the frequency of UA Doppler measurements is also controversial, because there are not enough randomized controlled studies (21). UA Doppler measurements can be repeated in every 2 weeks with non-stress test (NST) and AFI 2 times a week in IUGR with utero-placental insufficiency (21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the IUGR cases, the frequency of UA Doppler measurements is also controversial, because there are not enough randomized controlled studies (21). UA Doppler measurements can be repeated in every 2 weeks with non-stress test (NST) and AFI 2 times a week in IUGR with utero-placental insufficiency (21)(22)(23). If any abnormality is detected in Doppler studies, it can be repeated every week, unless end-diastolic flow gets lost (8).…”

Section: Discussionmentioning

confidence: 99%

The analysis of Doppler flow alterations in intrauterine growth restricted pregnancies

Ülkümen¹,

Pala²,

Eskicioğlu³

et al. 2014

Med Sci and Discov

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“…Among women with abnormal uterine artery Doppler examinations in the second trimester, several randomised controlled trials have been performed to see if secondary prevention of IUGR or pre‐eclampsia with aspirin or Vitamin C and E is possible. Unfortunately, none of these treatments have been shown to be effective 15 . Second trimester uterine artery Doppler examination may be beneficial in stratifying risk for subsequent antenatal care, and may be of further value in reassuring high risk women in the setting of normal findings.…”

Section: The Role Of Ultrasound In Screening For Iugrmentioning

confidence: 99%

The role of ultrasound in the diagnosis and management of the growth restricted fetus

Walker

2010

Australas J Ultrason Med

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Uterine artery Doppler flow studies in obstetric practice

Cited by 78 publications

References 22 publications

Transvaginal Color Doppler in the Assessment of Cervical Carcinoma and Pre-Cancer: Evidence from a Case Control Study Using Colour Doppler Ultrasonography Pulsatility Index of Uterine Vasculature

Transvaginal Color Doppler in the Assessment of Cervical Carcinoma and Pre-Cancer: Evidence from a Case Control Study Using Colour Doppler Ultrasonography Pulsatility Index of Uterine Vasculature

The analysis of Doppler flow alterations in intrauterine growth restricted pregnancies

The role of ultrasound in the diagnosis and management of the growth restricted fetus

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