Uterine artery Doppler velocimetry at 11–14 weeks in singleton pregnancies conceived by assisted reproductive technology

Prefumo, Federico; Fratelli, N.; Soares, Sérgia; Thilaganathan, B.

doi:10.1002/uog.3842

Cited by 22 publications

(20 citation statements)

References 32 publications

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“…Despite the high prevalence of PE in IVF pregnancies found in this study, we did not find any difference in mean UtA‐PI values. This is in agreement with previous reports and suggests that the mechanism behind the increased incidence of PE in IVF pregnancies is unlikely to be related to impaired uteroplacental perfusion. The absence of any prophylactic effect of low‐dose aspirin on the incidence of PE in IVF pregnancies, different from what occurs in natural pregnancies, further corroborates this hypothesis.…”

Section: Discussionsupporting

confidence: 93%

“…Despite the high prevalence of PE in IVF pregnancies found in this study, we did not find any difference in mean UtA-PI values. This is in agreement with previous reports 10,11 and suggests that the mechanism behind the increased incidence of PE in IVF pregnancies is unlikely to be related to impaired uteroplacental perfusion. The absence of any prophylactic effect of low-dose aspirin on the incidence of PE in IVF pregnancies, different from what occurs in natural pregnancies, further corroborates this hypothesis 25 -27 . A reduction in placental volume in pregnancies that develop PE has been reported previously by us and others and this finding appears to be independent of placental perfusion 15 -18 . To the best of our knowledge, this is the first study to analyze placental volume in IVF pregnancies.…”

Section: Discussionsupporting

confidence: 93%

“…This defective process of placentation is reflected in an increased impedance to flow in the uterine arteries (UtAs) that can be assessed from 11 weeks onwards by measuring UtA Doppler velocity waveforms. Despite the higher incidence of PE and hypertensive diseases in pregnancies resulting from IVF, no difference was found in UtA pulsatility index (UtA‐PI) when compared with spontaneously conceived pregnancies. This suggests that the increased risk of PE in IVF pregnancies may be secondary to a mechanism unrelated to UtA impedance to flow as measured by Doppler ultrasound.…”

Section: Introductionmentioning

confidence: 99%

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Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Rizzo

Aiello

Pietrolucci

et al. 2016

Ultrasound in Obstet & Gyne

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Rizzo

Aiello

Pietrolucci

et al. 2016

Ultrasound in Obstet & Gyne

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“… The higher risk of preeclampsia, fetal growth restriction and abnormal outcomes described in ART pregnancies and in spontaneous pregnancies with low free β ‐hCG and PAPP‐A further support the hypothesis that our results may be explained by abnormal placentation . Nonetheless, assessment of early placentation by means of uterine artery Doppler studies has shown no significant difference between spontaneous and ART pregnancy . Conception by IVF is associated with impairment of placental development, through a mechanism unrelated to clinically measurable impairment in placental perfusion .…”

Section: Discussionmentioning

confidence: 99%

Nuchal translucency measurement, freeβ-hCG and PAPP-A concentrations in IVF/ICSI pregnancies: systematic review and meta-analysis

et al. 2017

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So far, data on the effect of assisted reproductive technologies (ART) on the components of first trimester combined screening for Down syndrome are still controversial. A systematic search of the literature was performed in order to identify the effect of ART, particularly in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) with fresh embryo transfer, on the nuchal translucency, free beta-human chorionic gonadotrophin and pregnancy-associated plasma protein-A measurements. Moreover, a meta-analysis and a descriptive graphical representation of the ratios between ART and spontaneous pregnancies (controls) values of median of the multiple of median (m MoM) were performed. Free beta-human chorionic gonadotrophin test showed slightly higher values in the ICSI group than controls (RR = 1.09, 95%CI: 1.03-1.16) but not in the IVF group (RR = 1.03, 95%CI: 0.94-1.12). Pregnancy-associated plasma protein-A values for IVF/ICSI, IVF and ICSI showed lower values in comparison with controls (RR, 95%CI 0.85, 0.80-0.90; 0.82, 0.74-0.89 and 0.83, 0.79-0.86, respectively). The nuchal translucency measurement did not show any statistical differences between study groups (IVF and ICSI) and controls (RR = 1.00, 95%CI: 0.94-1.08 and RR = 1.01, 95%CI: 0.97-1.05, respectively). These results may be due to alterations in the placentation of ART pregnancies. Differentiating further subgroups of ART pregnancies may explain the differences in biomarker concentrations, in prenatal behavior and in obstetric outcomes between ART and spontaneous pregnancies. © 2017 John Wiley & Sons, Ltd.

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“…When combined with uterine artery Doppler, previous pregnancy and smoking history, this group was able to show a modest detection rate of 26% (8% FPR) . However, first trimester uterine artery Doppler as a single modality has no predictive capacity for spontaneous preterm birth in either spontaneous or assisted conceptions …”

Section: Spontaneous Preterm Birthmentioning

confidence: 92%

First trimester screening can predict adverse pregnancy outcomes

Sharp

Alfirević

2014

Prenatal Diagnosis

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Methods: We retrospectively reviewed and performed 4D-HDFI in 204 normal and 33 fetuses with confirmed diagnosis of cardiac anomalies of the great arteries. Cardiac volumes were available for post-analysis to obtain 4D rendered images of the great arteries. For the normal fetuses, two other traditional modalities including colour Doppler and HDFI were used to detect aortic arch and its branches and comparisons were made between each of these traditional methods and 4D-HDFI. Results: Two cases of interrupted aortic arch (IAA) type A, 3 cases of IAA type B, 5 cases of tetralogy of Fallot, 3 cases of double outlet right ventricle, 2 cases of truncus arteriosus, 2 cases of transposition of the great arteries, 2 cases of double aortic arch, 11 cases of right aortic arch with aberrant left subclavian arteries, 1 case of right aortic arch with mirror-image branching, and 2 cases of aberrant right subclavian artery were included in the current study. The 4D rendered images vividly depicted the origination, course, and the spatial relationship of the great arteries. For the normal fetuses, HDFI modality was superior to colour Doppler in detecting more brachiocephalic arteries throughout the gestational period. 4D-HDFI was the best method during the second trimester of pregnancy in identifying the greatest number of brachiocephalic arteries. Conclusions: HDFI and the advanced 4D-HDFI technique could facilitate identification of the anatomical features of the great arteries in both normal and abnormal fetuses, 4D-HDFI therefore provides additional and more precise information than conventional sonography techniques. Objectives: Prediction of pre-eclampsia (PE) before 34 and 37 weeks' at 11-14 weeks' in nulliparous women. Methods: All nulliparous women attending routine first-trimester ultrasound examination who delivered in our department between 2009 and 2016 were offered the 2016' FMF prediction model for PE before 34 and 37 weeks'. Risk assessment for PE included maternal factors, pregnancy-associated plasma protein-A (PAPP-A), mean maternal arterial blood pressure (MAP) and uterine artery Doppler (UtAPI). Risk was calculated for all nulliparous women optimally with all variables: PAPP-A + MAP + Ut IP, or pragmatically using only available parameters. Models performance was evaluated using receiver-operating characteristics (ROC) curve analysis in both groups. Results: 6,260 nulliparous women were included, 108 (1.7%) developed PE, including13 (0.2 %) and 41 (0.6%) before 34 and 37 weeks' respectively. Prediction models for PE before 34 and 37 weeks were optimal and suboptimal for 2080 (33.2%) and 4180 (66.8%) respectively. Prevalences were similar in both groups, 0.19% & 0.67% and 0.21% & 0.64%, respectively. The optimal model showed better AUC (95% CI) at predicting PE<34 and 37 weeks': 0.84 (0.66-1) V. 0.76 (0.50-1) and 0.91 (0.84-0.98) V. 0.81 (0.70-0.92), respectively. For a 10% false positive rate, the detection rate (95% CI) when using the optimal model was 20% higher than when using a suboptimal model <37 weeks'...

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Uterine artery Doppler velocimetry at 11–14 weeks in singleton pregnancies conceived by assisted reproductive technology

Cited by 22 publications

References 32 publications

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Placental volume and uterine artery Doppler evaluation at 11 + 0 to 13 + 6 weeks' gestation in pregnancies conceived with in‐vitro fertilization: comparison between autologous and donor oocyte recipients

Nuchal translucency measurement, freeβ-hCG and PAPP-A concentrations in IVF/ICSI pregnancies: systematic review and meta-analysis

First trimester screening can predict adverse pregnancy outcomes

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