Uterine Artery Hemodynamic Adaptations Through the Menstrual Cycle Into Early Pregnancy

Bernstein, Ira M.; Ziegler, William F.; Leavitt, Thomas; Badger, Gary J.

doi:10.1097/00006250-200204000-00021

Cited by 25 publications

(32 citation statements)

References 11 publications

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“…These findings are consistent with the majority of studies that have evaluated extremity blood flow during the menstrual cycle (17)(18)(25)(26), though not all (27). In addition, we found no effect of menstrual cycle phase on the insulin-stimulated increase in calf blood flow.…”

Section: Discussionsupporting

confidence: 92%

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Evidence against a role for ovarian hormones in the regulation of blood flow

Cooper

Sites

Fairhurst

et al. 2006

Fertility and Sterility

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Section: Discussionsupporting

confidence: 92%

“…Indeed, studies have shown that vasodilatation measured in large conduit arteries does not correlate with limb blood flow measurements by plethysmography (28 -30). Moreover, there may be regional differences in the effect of ovarian hormones on vascular function (25).…”

Section: Discussionmentioning

confidence: 99%

Evidence against a role for ovarian hormones in the regulation of blood flow

Cooper

Sites

Fairhurst

et al. 2006

Fertility and Sterility

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“…Another limitation pertains to the accuracy of the absolute flow estimates that can be achieved using Doppler ultrasound. While we and others have previously shown that pericutaneous Doppler ultrasound is reproducible and capable of accurately assessing changes within subjects and differences between groups within a given study (2,33), the accuracy of the volumetric flow values in some vessels is limited. In particular, CI flows are probably underestimated, as judged by the fact that they are markedly less than the sum of the UA and EI flows.…”

Section: Discussionmentioning

confidence: 91%

Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents

Wilson

López²,

Vargas

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Multigenerational (Andean) compared with shorter-term (European) high-altitude residents exhibit less hypoxia-associated reductions in birth weight. Because differences in arterial O(2) content are not responsible, we asked whether greater pregnancy-associated increases in uterine artery (UA) blood flow and O(2) delivery were involved. Serial studies were conducted in 42 Andean and 26 European residents of La Paz, Bolivia (3600 m) at weeks 20, 30, 36 of pregnancy and 4 mo postpartum using Doppler ultrasound. There were no differences postpartum but Andean vs. European women had greater UA diameter (0.65 +/- 0.01 vs. 0.56 +/- 0.01 cm), cross-sectional area (33.1 +/- 0.97 vs. 24.7 +/- 1.18 mm(2)), and blood flow at week 36 (743 +/- 87 vs. 474 +/- 36 ml/min) (all P < 0.05) and thus 1.6-fold greater uteroplacental O(2) delivery near term (126.82 +/- 18.47 vs. 80.33 +/- 8.69 ml O(2).ml blood(-1).min(-1), P < 0.05). Andeans had greater common iliac (CI) flow and lower external iliac relative to CI flow (0.52 +/- 0.11 vs. 0.95 +/- 0.14, P < 0.05) than Europeans at week 36. After adjusting for gestational age, maternal height, and parity, Andean babies weighed 209 g more than the Europeans. Greater UA cross-sectional area at week 30 related positively to birth weight in Andeans (r = +0.39) but negatively in Europeans (r = -0.37) (both P < 0.01). We concluded that a greater pregnancy-associated increase in UA diameter raised UA blood flow and uteroplacental O(2) delivery in the Andeans and contributed to their ability to maintain normal fetal growth under conditions of high-altitude hypoxia. These data implicate the involvement of genetic factors in protecting multigenerational populations from hypoxia-associated reductions in fetal growth, but future studies are required for confirmation and identification of the specific genes involved.

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“…An endometrial thickness of R9 mm in the late proliferative phase, as determined by vaginal ultrasound, correlates well with the chance of pregnancy after IVF, whereas a thinner endometrium is associated with poorer prognosis for success (1,7). Increased blood flow in the uterine arteries during the menstrual cycle predicts the uterine arteries' hemodynamic adaptation established during early pregnancy (12). The presence of a protodiastolic notch in the uterine arteries predicts successful implantation (13).…”

mentioning

confidence: 99%