Uterine atrophy in chronic murine toxoplasmosis due to ovarian dysfunction

Stahl, William L.; Kaneda, Yoshimasa; Tanabe, Masaya; Kumar, Salil

doi:10.1007/bf00931614

Cited by 16 publications

(7 citation statements)

References 11 publications

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“…10,11 At some papers on workroom animals had been exposed that infection with T. gondii due to sterility during chronictoxoplasmosis, the laboratory -animals in (rat's female) maybe foundation Endometriosis, weak-follicles, debility ovaries, leanness in the ovaries and uterus, depression in adrenal glands inflation, genital action , cessation of reproduce to failure, vascular inflammation in experimental menstrual dysplasia and mice. [12][13][14]…”

Section: Research Articlementioning

confidence: 99%

Study the Correlation between Pathogenic Parasitic Infections and Infertility among Women in Kerbala province, Iraq

Radhi¹,

Jassem²,

Abbas³

et al. 2022

IJDDT

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This study indicated that infections with pathogenic–parasitic (PP) causes in healthy controls who do not suffer infertility will be higher than those of infertile women. Correspondingly, in parasitic infections in (protozoa) were prevalent among numerous parts of the world. Developed countries and infertile women were the major burden and infections, for example, the women’s reproductive system through damage to infertile women. There were approximately parasitic infections such as Trichomonas vaginalis could reason cervical tumors, non-anomalous pelvic infections in women and tubal and genital tract abnormalities. Toxoplasma gondii reasons dysplasia of reproductive tract, synthetic disorders and endometriosis for example, intrauterine adhesions.

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Section: Research Articlementioning

confidence: 99%

Study the Correlation between Pathogenic Parasitic Infections and Infertility among Women in Kerbala province, Iraq

Radhi¹,

Jassem²,

Abbas³

et al. 2022

IJDDT

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“…Infectious diseases are amongst the most frequent causes for male and female reproductive pathology and infertility, in humans and animals (Bennett, Dolin, & Blaser, ; Maxie, ). Reproductive tissue tropism has been studied in the context of Trichomonas (Parsonson, Clark, & Dufty, ) , T. gondii (Lopes et al, ; Stahl, Kaneda, Tanabe, & Kumar, ), T. cruzi (Id Boufker, Alexandre, Carlier, & Truyens, ), T. brucei (Carvalho et al, ), Plasmodium (Muehlenbein, Alger, Cogswell, James, & Krogstad, ; Raji, Akinsomisoye, & Azeez, ) , Entamoeba (reviewed in [Antony and Lopez‐Po ]) and to a large extend in Leishmania (Assis, Ribeiro, Rachid, Castro, & Valle, ; Blickstein, Dgani, & Lifschitz‐Mercer, ; Cabello, Caraballo, & Millan, ; Diniz et al, ; Gonzalez, Gallego, Castaño, & Rueda, ; Mir, Fontaine, Reyes‐Gomez, Carlus, & Fontbonne, ; Schubach, Cuzzi‐Maya, Gonçalves‐Costa, Pirmez, & Oliveira‐Neto, ). Infertility can be directly associated with presence of parasites in the tissue, through triggering inflammation and tissue damage or indirectly due to systemic effects that result in impaired reproductive function.…”

Section: Organs In the Abdominopelvic Cavitiesmentioning

confidence: 99%

Intravital imaging of host‐parasite interactions in organs of the thoracic and abdominopelvic cavities

Niz

Carvalho

Penha‐Gonçalves

et al. 2020

Cellular Microbiology

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Infections with protozoan and helminthic parasites affect multiple organs in the mammalian host. Imaging pathogens in their natural environment takes a more holistic view on biomedical aspects of parasitic infections. Here, we focus on selected organs of the thoracic and abdominopelvic cavities most commonly affected by parasites. Parasitic infections of these organs are often associated with severe medical complications or have health implications beyond the infected individual. Intravital imaging has provided a more dynamic picture of the host-parasite interplay and contributed not only to our understanding of the various disease pathologies, but has also provided fundamental insight into the biology of the parasites. K E Y W O R D S diseases, imaging, infection, intravital, microscopy, parasitology 1 | INTRODUCTION Most parasitic infections in mammals involve organs of the thoracic, abdominal and pelvic cavities, and may cause severe complications as a result of damage to these organs. Organs in the thoracic cavity include the heart, the lungs, the thymus, the thyroid and parathyroid.The heart is an important target of Trypanosoma cruzi; and the lungs, are key targets of multiple parasites causing a broad spectrum of pathology ranging from focal lesions to diffuse lung damage. In the abdominal cavity, organs include the stomach, the intestine, the liver, the gallbladder, the pancreas, the spleen, the kidneys, the adrenal glands and regional lymph nodes. In the pelvic cavity, the reproductive organs and the urinary bladder are harboured. All the above organs can be compromised by vector-borne and soil/water/food-borne parasites alike. Intravital microscopy (IVM) allows studying cellular and sub-cellular events within living animals, including host-pathogen interactions. In this review, we focus on key IVM-based findings on parasite biology in different organs of the thoracic and abdominopelvic cavities. Importantly, some of these organs pose specific challenges for visualisation. Here, we discuss the advances on surgical procedures, imaging platforms and image processing tools that have made visualisation of parasites within these organs possible. | ORGANS IN THE THORACIC CAVITYThe organs in the thoracic cavity most frequently affected by parasites are the lungs and heart (Figure 1a). The heart as the central organ of the circulatory system carries out vital functions by distributing blood, oxygen and nutrients to tissues and removing metabolic waste

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“…In rodents, many other parasitic infections involving protozoa, such as trypanosomiasis and toxoplasmosis (Hublart et al 1990;Tavares et al 1994;Stahl et al 1995), or involving larval tapeworms (Lin et al 1990; Morales-Montor et al 1999), have been associated with hormonal perturbations which greatly impair the sexual functions of the host. Curiously, although Akingbade et al (1990) demonstrated that the acute phase of a Plasmodium berghei infection induces a hormonal imbalance in female Wistar mice, no dysfunctions in the sexual physiology and no modifications of the genital tract were reported in infected females.…”

Section: Introductionmentioning

confidence: 98%

Oestrus cycle perturbations and hypotrophy of clitoral glands in malaria-infected female BALB/c mice

Barthélemy

Vuong

Gabrion

et al. 2003

Parasitology Research

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An experimental host-parasite association involving BALB/c female mice infected with Plasmodium vinckei petteri was used with the aim of investigating the morphological and physiological alterations induced by the parasite in the genital tract of the host. The vaginal oestrous cycle was monitored as a daily clue to the sexual physiology of the female mice, and a complete histological analysis of the genital tract was performed 36 days following parasite inoculation. The oestrous cycle showed strong transitory alterations during the first 30 days following infection. The occurrence of oestrus days increased during the first 10 days post-infection and then decreased to a subnormal value during the following 20 days. Infected mice also showed a remarkable hypotrophy of their clitoral glands 30 days after the beginning of the malarial infection. A probable cause of such perturbations is a significant hormonal imbalance triggered by the erythrocytic proliferation of the Plasmodium. The relationship between the immune response of the host and these physiological and morphological alterations, as well as the outcomes of these alterations on the sexuality of the rodent host are discussed.

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Uterine atrophy in chronic murine toxoplasmosis due to ovarian dysfunction

Cited by 16 publications

References 11 publications

Study the Correlation between Pathogenic Parasitic Infections and Infertility among Women in Kerbala province, Iraq

Study the Correlation between Pathogenic Parasitic Infections and Infertility among Women in Kerbala province, Iraq

Intravital imaging of host‐parasite interactions in organs of the thoracic and abdominopelvic cavities

Oestrus cycle perturbations and hypotrophy of clitoral glands in malaria-infected female BALB/c mice

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