Uterine Atypical Polypoid Adenomyoma and Ovarian Endometrioid Carcinoma

Duggan, Máire A.; Rowlands, Caroline G.; Kneafsey, Paul; Nation, Jill; Stuart, Gavin

doi:10.1097/00004347-199501000-00014

Cited by 11 publications

(6 citation statements)

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“…Therefore, the involvement of HPV infection in epithelial ovarian cancer has been an interesting issue. However, previous studies in different laboratories provided highly controversial results (Kaufman et al, 1987;Leake et al, 1989;Beckmann et al, 1991;Lai et al, 1992Lai et al, , 1994Duggan et al, 1995;Runnebaum et al, 1995;Sworn et al, 1995;Trottier et al, 1995;Anwar et al, 1996;Kedzia et al, 1996;Mai et al, 1996;Zimna et al, 1997;Manolitsas et al, 1998;Anttila et al, 1999;Chen et al, 1999;Ip et al, 2002). We report here that HPV-16 was found in a series of histologically characterised epithelial ovarian carcinomas from Chinese women.…”

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confidence: 55%

Detection of human papillomavirus-16 in ovarian malignancy

Guo

et al. 2003

Br J Cancer

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Human papillomavirus is the causal factor for cervical cancer. However, the role of HPV infection in ovarian cancer is unclear. This study aimed to determine the presence of human papillomavirus-16 (HPV-16) in ovarian cancer tissues. Archived human ovarian cancer tissues (N ¼ 54 cases, 50 are epithelial cancer, four are nonepithelial cancer) embedded in paraffin blocks were used. Controls are 30 nonmalignant ovarian tissue blocks. In situ hybridisation (ISH) and immunohistochemistry (IHC) were used to detect the presence of HPV-16 and p53 expression. In all, 52 or 36% of the epithelial ovarian tumours detected by ISH or IHC, respectively, were HPV-16 E6 positive. In contrast, only 6.7% of normal ovarian tissues were HPV-16 positive proved by ISH. Human papillomavirus-16 infection was significantly higher in cancer tissues compared to controls with an odds ratio of 16.7 (95% confidence interval [CI] ¼ 3.2 -71.4, Po0.01). No significant correlation between HPV-16 infection and histological types of cancer was found (P40.05). p53 gene expression was detected in 42% epithelial ovarian cancers. No correlation between p53 expression and HPV-16 infection was found. The results showed the presence of HPV-16 E6 in ovarian carcinoma, suggesting that HPV infection might play a role in ovarian carcinogenesis.

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confidence: 55%

Detection of human papillomavirus-16 in ovarian malignancy

Guo

et al. 2003

Br J Cancer

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“…It appears that several research groups (particularly in China), using a variety of molecular‐based approaches, have been able to detect primarily HPV types 16 and 18 in a relatively small subset of both benign and malignant ovarian tissues 1–12 . A number of factors may contribute to the variability of HPV detection in ovarian tumors.…”

Section: Discussionmentioning

confidence: 99%

“…It appears that several research groups (particularly in China), using a variety of molecular-based approaches, have been able to detect primarily HPV types 16 and 18 in a relatively small subset of both benign and malignant ovarian tissues. [1][2][3][4][5][6][7][8][9][10][11][12] A number of factors may contribute to the variability of HPV detection in ovarian tumors. These factors include: (i) existing geographic variations in host and pathogen genetic makeup; (ii) notable differences in the sensitivity and specificity of HPV detection methods utilized in different laboratories; and (iii) potentially important differences in the characteristics of the tumor material analyzed in each study, including the age of patients and the various histological types of tumors (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…While the role of human papillomavirus (HPV) infection with cervical cancer and its associated precancerous lesions has been substantially documented, the data on a potential association of HPV infection with ovarian neoplasia is conflicting. Some studies and case reports have documented the presence of HPV in benign and malignant ovarian tissues, [1][2][3][4][5][6][7][8][9][10][11][12] while a number of others have not. [13][14][15][16][17][18][19][20][21][22] Additional studies are clearly needed to help determine the contribution, if any, of HPV infection in ovarian tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of ovarian tumors for the presence of human papillomavirus DNA

Quirk

Kupinski

DiCioccio

2006

J of Obstet and Gynaecol

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“…Hormonal factors may play an important role in the development of these tumours (Duggan et al, 1995). It is known that APA occur usually in premenopausal patients (Mazur, 1981), almost half of them nulliparous (Longacre et al, 1996), and that the uninvolved endometrium may show proliferative features or hyperplasia in many cases.…”

Section: Discussionmentioning

confidence: 99%

Atypical polypoid adenomyoma of the uterine cervix: a diagnostic problem

Ramos

Santana

Ruiz

et al. 2003

Journal of Obstetrics and Gynaecology

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IntroductionAtypical polypoid adenomyoma (APA) is an uncommon polypoid lesion of the uterus described first by Mazur in 1981, featuring a proliferation of irregular endometrial glands with squamous metaplasia, embedded within a prominent cellular smooth-muscle stroma. In contrast to adenomyoma, APA contains architecturally complex and cytologically atypical glands that can be confused with well-differentiated adenocarcinoma, but it is distinguished from invasive endometrial carcinoma by its prevalence in younger patients, usually premenopausal women, and by the presence of a cellular, sometimes mitotically active smooth muscle stroma (Longacre et al., 1996). Early clinicopathological series of APAs emphasised the benign clinical character of these proliferations, but the overall prognosis, risk of recurrence and the malignant nature of these problematic lesions are not fully known (Clement and Young, 1987). We report another case of APA of the cervix followed by a discussion on the most appropriate therapeutic measures. To our knowledge, hardly more than 100 cases of this lesion have been reported so far in the English literature (Fukunaga, 1995).

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Uterine Atypical Polypoid Adenomyoma and Ovarian Endometrioid Carcinoma

Cited by 11 publications

References 0 publications

Detection of human papillomavirus-16 in ovarian malignancy

Detection of human papillomavirus-16 in ovarian malignancy

Analysis of ovarian tumors for the presence of human papillomavirus DNA

Atypical polypoid adenomyoma of the uterine cervix: a diagnostic problem

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