Uterine Cancer (Corpus Uteri)

Einhorn, Nina

doi:10.3109/02841869609101667

Cited by 8 publications

(3 citation statements)

References 50 publications

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“…The long-term continuing improvement is likely a combination of many small improvements happening over time, ranging from improved knowledge of prognostic factors and their importance in choice of treatment, to improved surgical methods gradually being implemented [ 32 ]. In Sweden the treatment of endometrial cancer has traditionally been characterized by a liberal use of both preoperative and postoperative radiation [ 33 ]. This tradition was broken by a treatment program in the Southern Health Care Region 1993 to 1996 [ 34 ], which minimized radiation therapy and showed no detrimental effect on survival.…”

Section: Discussionmentioning

confidence: 99%

Increased incidence and improved survival in endometrial cancer in Sweden 1960–2014: a population-based registry survey

et al. 2023

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Background An investigation of trends of incidence and net survival (NS) for endometrial cancer in Sweden. Methods Morphologically verified endometrial carcinoma diagnosed 1960 to 2014 were collected from the nation-wide Swedish Cancer Registry. Endometrial cancer patients were assessed with regards to time trends for incidence and 54,825 cases remained for survival analyses. Cases diagnosed 1995 to 2014 were categorized according to detailed morphology and from 2005 to 2014 FIGO stage was also categorized. Results There was a trend of increasing incidence of endometrial carcinoma for women above 55 years of age. NS was improved at 5- and 10-year follow-up. The 5-year net survival in 2010–2014 was 86%. The most prominent improvement in NS was found in the elderly women above 75 years of age. Conclusions This study observed increased incidence of endometrial cancer in Sweden from 1960 to 2014. The progress in diagnostics and treatment, seem to have improved the net survival, especially in elderly women.

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Section: Discussionmentioning

confidence: 99%

Increased incidence and improved survival in endometrial cancer in Sweden 1960–2014: a population-based registry survey

et al. 2023

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“…We were concerned about the Swedish therapy tradition with a liberal use of adjuvant radiotherapy ( 17 ) , despite the fact that convincing survival benefits had not been shown ( 18 ) . Based on our results cited above, we decided to use DNA ploidy as a complement to histopathologic evaluation and prospectively divide patients with nonserous, nonclear‐cell early endometrial cancer into two groups.…”

mentioning

confidence: 99%

A prospective population-based management program including primary surgery and postoperative risk assessment by means of DNA ploidy and histopathology. Adjuvant radiotherapy is not necessary for the majority of patients with FIGO stage I-II endometrial cancer

Högberg¹,

Fredstorp-Lidebring

Alm

et al. 2004

Int J Gynecol Cancer

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A management program for FIGO stage I-II nonserous, nonclear-cell adenocarcinomas was evaluated. Histopathology and DNA ploidy were used to estimate postoperatively the risk of progression or death of disease and to tailor treatment. The patient material was a population-based consecutive cohort of all women with endometrial cancer in the Southern Swedish Health Care Region diagnosed between June 1993 and June 1996 (n = 553). Of these, 335 were eligible for the management program. Patients estimated to be at low risk were treated by surgery only, while high-risk patients also received vaginal brachytherapy. A large low-risk group consisting of 84% (n = 283) of the patients with an estimated disease-specific 5-year survival of 96% (95% CI = 93-98%) was identified. The high-risk group (n = 52, 16%) showed a worse outcome with an 80% 5-year disease-specific survival (95% CI = 65-89%). The difference in survival between the groups was highly significant (P < 0.0001). Half of the progressions were distant in the high-risk group. Although there is a clear indication for adjuvant therapy for this group, locoregional radiotherapy could be expected to fail in cases with distant progression. Thus, effective systemic treatments need to be developed. Low-risk patients, constituting the majority (84%) of the patients, can be safely treated by surgery only.

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“…A análise de mutações germinativas em genes associados à síndrome de Lynch é fortemente recomendada para as mulheres cujos tumores de endométrio foram caracterizados como sendo deficientes do sistema de reparo MMR. de todos os casos de câncer no corpo do útero, os demais casos são compostos por tumores que se originam a partir do miométrio (EINHORN, 1996;PATEL et al, 2010).…”

Section: Introductionunclassified

Caracterização molecular de tumores de endométrio quanto à proficiência do sistema de reparo de pareamento incorreto de DNA

Rosa¹

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pelos inúmeros e valiosos ensinamentos transmitidos durante todo este período, com certeza eles contribuíram em muito para meu aprimoramento profissional e pessoal. Agradeço ainda por ter aceitado me orientar e por ter acreditado e confiado em mim, desde o primeiro dia de mestrado. Muito obrigado pela orientação totalmente presente e dedicação constante durante todas as etapas deste trabalho.

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Uterine Cancer (Corpus Uteri)

Cited by 8 publications

References 50 publications

Increased incidence and improved survival in endometrial cancer in Sweden 1960–2014: a population-based registry survey

Increased incidence and improved survival in endometrial cancer in Sweden 1960–2014: a population-based registry survey

A prospective population-based management program including primary surgery and postoperative risk assessment by means of DNA ploidy and histopathology. Adjuvant radiotherapy is not necessary for the majority of patients with FIGO stage I-II endometrial cancer

Caracterização molecular de tumores de endométrio quanto à proficiência do sistema de reparo de pareamento incorreto de DNA

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