Uterine carcinosarcoma: a primer for radiologists

Ravishankar, Pavitra; Smith, Daniel A.; Avril, Stefanie; Kikano, Elias; Ramaiya, Nikhil H.

doi:10.1007/s00261-019-02038-8

Cited by 19 publications

(46 citation statements)

References 46 publications

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“…Clinical presentation is often the triad of abnormal uterine bleeding, pain, and a rapid uterus enlargement [ 7 ]. In physical examination, the tumor presents as a relatively large polypoid mass which could protrude from the cervix, posing the risk of uterus inversion [ 7 ]. Uterine carcinosarcomas have high rates of lymphatic spread, peritoneal seeding, and pulmonary metastasis [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Uterine carcinosarcomas have high rates of lymphatic spread, peritoneal seeding, and pulmonary metastasis [ 18 ]. Approximately 30–40% of cases have extrauterine involvement at the first presentation, extrauterine nodal spread being widely prevalent, and over 10% of patients initially present with distant metastasis [ 7 ]. These contribute to the poor prognosis of this rare disease.…”

Section: Discussionmentioning

confidence: 99%

“…These contribute to the poor prognosis of this rare disease. Differential diagnoses consist of endometrial carcinomas (e.g., endometrioid, serous, clear cell, and dedifferentiated carcinomas), as well as mesenchymal malignancies of the uterus (e.g., adenosarcoma, leiomyosarcoma, and undifferentiated uterine sarcoma) [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Uterine carcinosarcomas are extremely aggressive undifferentiated carcinomas which include both carcinomatous and sarcomatous elements, arising from a single malignant epithelial clone [ 2 – 6 ]. The prognosis is often poor, with 30–40% of cases having extrauterine involvement at the first presentation [ 7 ]. The clinical presentation of the uterine carcinosarcomas is nonspecific, and imaging and pathology studies play an important role in diagnosis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The prognosis is often poor, with 30–40% of cases having extrauterine involvement at the first presentation [ 7 ]. The clinical presentation of the uterine carcinosarcomas is nonspecific, and imaging and pathology studies play an important role in diagnosis [ 7 ]. In this study, we present a rare case of uterine carcinosarcoma with a concise review of the most prominent radiologic and histologic characteristics of this rare entity.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Uterine Carcinosarcoma: A Case Report and Literature Review

Valeshabad

Rabiee

Younes

2020

Case Reports in Obstetrics and Gynecology

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Uterine carcinosarcomas are rare and extremely aggressive undifferentiated carcinomas which include both carcinomatous and sarcomatous elements. A 52-year-old female presented with heavy irregular menstrual bleeding for several years and new right elbow pain and swelling. Ultrasound and computed tomography showed a large uterine mass with regional and distant metastatic lymphadenopathy and suspicious findings of osseous metastasis to the right elbow. A biopsy confirmed uterine carcinosarcoma, and the patient underwent chemotherapy and then surgical resection of the uterine mass with palliative radiotherapy of the right elbow. The postoperative imaging showed new metastasis, and the patient was scheduled to start on immunotherapy. Considering the highly invasive nature of uterine carcinosarcomas, timely detection of this cancer using characteristic imaging and pathology findings is of extreme importance to improve the patient’s survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%