Uterine cervical cancer associated with obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome: A case report and review of the literature

Oka, Emiko; Chiyoda, Tatsuyuki; Iwata, Takashi; Yamagami, Wataru; Aoki, Daisuke

doi:10.1016/j.gore.2020.100645

Cited by 4 publications

(1 citation statement)

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“…The incidence of OHVIRA syndrome remains unknown, with few published case reports thus far. Very few reports are available regarding OHVIRA syndrome with cancer, particularly uterine cervical cancer [ 11 ]. Kaba et al also reported a case of cervical endometrioid adenocarcinoma diagnosed with OHVIRA syndrome [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Carcinoma of the Cervix With OHVIRA Syndrome: A Rare Case Report

et al. 2021

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Obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) syndrome is a rare Mullerian duct anomaly characterized by an obstructed hemivagina, ipsilateral renal agenesis, and uterine didelphys. There are only a few published case reports of OHVIRA syndrome, and cases of OHVIRA syndrome associated with cancer have rarely been reported. In fact, there is only one published report of a case with clear cell carcinoma (CCC) of the cervix. Here, we report a case of CCC of the cervix with OHVIRA syndrome that underwent abdominal radical hysterectomy; we also provide a short literature review of this topic. A 52-year-old woman presented with abnormal vaginal bleeding for 1 month 2 years after menopause. A pelvic examination and preoperative imaging showed uterine didelphys, an obstructed hemivagina with a mass measuring approximately 2 cm located in her left cervix, and an absence of her left kidney. A colposcopy biopsy reported CCC of the cervix. Clinical staging classified her with stage IB1 disease. Abdominal radical hysterectomy was performed. Her left ectopic ureter led to the left cervix and opened in the endometrium, resulting in a so-called ectopic ureter. Macroscopic examination of the excised specimens showed two cervixes, two corpora of the uterus, and a tumor measuring 1.0 × 2.0 cm on the left cervix. In addition to typical OHVIRA symptoms including uterine didelphys, obstructed hemivagina, and renal agenesis, several anatomical variants were present. The current case included those variants as well as an atrophic kidney with an ectopic ureter to the obstructed hemivagina. Based on the results of our case, clinicians should be aware of the risks of cancer and anatomical variants associated with OHVIRA syndrome.

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Section: Discussionmentioning

confidence: 99%