Uterine Clear Cell Carcinoma

Nguyen, Julie My Van; Bouchard-Fortier, Geneviève; Bernardini, Marcus Q.; Atenafu, Eshetu G.; Han, Guangming; Vicus, Danielle; Ferguson, Sarah E.; Gien, Lilian T.

doi:10.1097/igc.0000000000000839

Cited by 7 publications

(9 citation statements)

References 37 publications

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“…Creasman et al [8] reported that 15% of patients with UCCC had no MMI with a 5-year OS rate of 83%. The prevalence of non-invasive UCCC has been reported to be 14%–16% in previous studies [610]. However, Abeler and Kjørstad [5] reported that 90% of women with no MMI survived 5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Nguyen et al [10] reported that adjuvant treatment may not be needed in stage I UCCC confirmed with surgical staging, particularly for those with lower risk factors such as superficial MMI and no LVSI. Maggino et al [18] suggested that both chemotherapy and radiotherapy might be unnecessary in patients with stage IA and IB, in their cohort of 65 women with UCCC.…”

Section: Discussionmentioning

confidence: 99%

“…Up to 40%–50% of patients with disease clinically confined to the uterus may present with extra-uterine disease, even in the absence of myometrial invasion (MMI) [79]. The recurrence rate of UCCC has been reported to be 14% in early-stage, and 56% in advanced-stage disease, respectively [10]. Given the rarity of UCCC, optimal surgical and postoperative management remains undefined [11].…”

Section: Introductionmentioning

confidence: 99%

“…Given the limited extent of the disease but its aggressive biologic behavior, it is unclear whether adjuvant therapy is warranted in this clinical setting [101112]. Therefore, we focused on combining multi-institutional data sets of women with non-invasive UCCC.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study

et al. 2017

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ObjectiveTo assess the prognosis of surgically-staged non-invasive uterine clear cell carcinoma (UCCC), and to determine the role of adjuvant therapy.MethodsA multicenter, retrospective department database review was performed to identify patients with UCCC who underwent surgical treatment between 1997 and 2016 at 8 Gynecologic Oncology Centers. Demographic, clinicopathological, and survival data were collected.ResultsA total of 232 women with UCCC were identified. Of these, 53 (22.8%) had surgically-staged non-invasive UCCC. Twelve patients (22.6%) were upstaged at surgical assessment, including a 5.6% rate of lymphatic dissemination (3/53). Of those, 1 had stage IIIA, 1 had stage IIIC1, 1 had stage IIIC2, and 9 had stage IVB disease. Of the 9 women with stage IVB disease, 5 had isolated omental involvement indicating omentum as the most common metastatic site. UCCC limited only to the endometrium with no extra-uterine disease was confirmed in 41 women (73.3%) after surgical staging. Of those, 13 women (32%) were observed without adjuvant treatment whereas 28 patients (68%) underwent adjuvant therapy. The 5-year disease-free survival rates for patients with and without adjuvant treatment were 100.0% vs. 74.1%, respectively (p=0.060).ConclusionExtra-uterine disease may occur in the absence of myometrial invasion (MMI), therefore comprehensive surgical staging including omentectomy should be the standard of care for women with UCCC regardless of the depth of MMI. Larger cohorts are needed in order to clarify the necessity of adjuvant treatment for women with UCCC truly confined to the endometrium.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study

et al. 2017

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“…For example, in a multi-institute review of patients with UCCC and no gross evidence of extrauterine disease, it was shown that 52% (39/69) had their disease upstaged at the time of surgery [4]. Similarly, Nguyen et al [5] revealed that 46% (59/129) of patients with clinical stage I UCCC had extrauterine spread. These reports support the argument that UCCC can spread early, including to the lymph nodes and omentum.…”

mentioning

confidence: 99%

Surgical management of non-invasive uterine clear cell carcinoma

2017

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Uterin seröz karsinom ve uterin berrak hücreli karsinom tanısı alan hastalarda klinikopatolojik özelliklerin ve sağ kalım sonuçlarının karşılaştırılması

Cüylan¹,

Aslan²,

Korkmaz³

et al. 2020

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Uterin seröz karsinom (USK) ve uterin berrak hücreli karsinomların (UBHK) klinikopatolojik özelliklerinin ve hastaların sağ kalım sonuçlarının karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Final patoloji raporlarına göre, USK ve UBHK tanısı alan hastalar çalışma grubunu oluşturmaktadır. Demografik, kilnikopatolojik ve sağkalım verileri analiz edildi. Bulgular: USK grubunda 69 ve UBHK grubunda 36 hasta analiz edildi. USK grubunda hastaların UBHK grubundaki hastalarla karşılaştırıldığında, istatistiksel olarak anlamlı derecede daha ileri evre hastalığı sahip olduğu saptandı (sırasıyla %61,1 ve %36,2, p=0.015). USK grubundaki hastaların UBHK grubundaki hastalar ile karşılaştırıldığında daha fazla omental metastaza (17/69 ve 2/36, p=0,016) ve peritoneal sitoloji pozitifliğine (25/69 ve 5/36, p=0,016) sahip olduğu bulundu. Tüm kohort için multivaryan analizde sadece peritoneal sitoloji pozitifliğinin azalmış hastalıksız sağkalım (DFS) için bağımsız risk faktörü olduğu bulundu (HR 5,07 95% CI 2,07-12,42; p<0,001). Tüm kohort için, multivaryan analizde sadece peritoneal sitolojinin pozitif olması azalmış kaba sağkalım (OS) için bağımsız risk faktörü olarak bulundu (HR 3,50 95% CI 1,33; p=0,012). Sonuç: Sonuç olarak çalışmamızda USK ve UBHK tanısı alan hastalarda sitoloji pozitifliğini hem DFS hem de OS için bağımsız prognostik faktör olarak saptadık. Ayrıca USK grubundaki hastalarda omental metastaz oranlarının yüksek olması nedeniyle omentektominin cerrahi evrelemenin bir komponenti olması gerektiğini düşünmekteyiz.

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Uterine Clear Cell Carcinoma

Abstract: The high rate of upstaging after surgery highlights the importance of lymph node assessment. The high rate of distant recurrence questions the effectiveness of current CT regimens and warrants the development of novel systemic approaches. The role of adjuvant RT deserves further study.

Cited by 7 publications

References 37 publications

Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study

Prognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group study

Surgical management of non-invasive uterine clear cell carcinoma

Uterin seröz karsinom ve uterin berrak hücreli karsinom tanısı alan hastalarda klinikopatolojik özelliklerin ve sağ kalım sonuçlarının karşılaştırılması

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