Uterine Control of Ovarian Function

Anderson, Lloyd L.; Musah, A. I.

doi:10.1007/978-1-4684-2271-9_16

Cited by 9 publications

(1 citation statement)

References 374 publications

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“…Although there is no embryo implantation in the uterus, in pseudopregnancy cases, the histomorphological changes are detected in the tissue (Abd-Elkareem 2017). These changes are nonspeci c trauma-related decidual cell differentiation and hyperemic and swelling featured uterine tissue which are observed at the middle stage of pseudopregnancy (Peel et al 1979;Anderson and Musah 2013). Owing to the enhancement of plasma progesterone level, mucosal plica, glandular formation, epithelial proliferation and thickening of the uterine wall are seen in this syndrome.…”

Section: Histopathological Analysismentioning

confidence: 99%

Phytochemical analysis and beneficial effects of Artemisia absinthium L. essential oil in rat pseudopregnancy model

Demırel¹,

Süntar²,

Çeribaşı³

et al. 2022

Preprint

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Pseudopregnancy is a luteal phase syndrome in which steroids, prolactin inhibitor agents or ovariectomy/ovariohysterectomy are used in the treatment. New medical strategies should be developed because of the serious side effects of current treatment regimens. Several plants and natural compounds are investigated for their modulatory effect on hormonal balance in the treatment of pseudopregnancy. Artemisia absinthium L. (wormwood) is a medicinal plant that belongs to the Asteraceae family, used as an emmenagogue and to induce abortus traditionally. This plant has a regulatory effect on the dopaminergic system. In this study, the therapeutic potential of the A. absinthium essential oil was examined in an experimentally-induced pseudopregnancy model in rats. The pseudopregnancy model was induced by injection of a pregnant mare’s serum gonadotropin and human chorionic gonadotropin to female rats. Essential oil of A. absinthium was orally administered to the rats at 12.5 mg/kg, 25 mg/kg and 50 mg/kg doses once daily for 10 days. Bromocriptine (3 mg/kg/per os) was administered to the reference group animals. Gas Chromatography analysis was conducted on the essential oil to reveal its phytochemical profile. A. absinthium essential oil at 25 mg/kg dose displayed beneficial effects in the pseudopregnancy model in rats. Cis-chrysanthenyl acetate (17.8), sabinyl acetate (11.6%), terpinen-4-ol (6.2%), caryophyllene oxide (5.5%) and (E)-nuciferol (5.5%) were found as the major components in the oil. A. absinthium essential oil rich in cis-chrysanthenyl acetate, sabinyl acetate, terpinen-4-ol, caryophyllene oxide, and (E)-nuciferol should be displayed therapeutic activity against pseudopregnancy.

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Section: Histopathological Analysismentioning

confidence: 99%

Phytochemical analysis and beneficial effects of Artemisia absinthium L. essential oil in rat pseudopregnancy model

Demırel¹,

Süntar²,

Çeribaşı³

et al. 2022

Preprint

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The effects of pelvic neurectomy on collagen in the cervix of the pseudopregnant rat

et al. 1984

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Bilateral section of the pelvic parasympathetic nerves (pelvic-neurectomy) on day 5 of pseudopregnancy had no effect on the wet weight of ovaries, uteri, and/or cervices, but at day 9 serum progesterone was reduced to approximately half that of sham-operated animals. Collagen in the cervix was visualized with picrosirius red staining under polarization microscopy. Pelvic neurectomy decreased the birefringence of Type 1 collagen in the cervix to less than half that of sham operated animals. The decreased birefringence, an index of the organization of collagen fibers, is believed to be attributable to reduced progesterone levels. Alternatively, the pelvic nerve may directly influence mucopolysaccharides or collagenolytic enzymes in the cervix.

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Parturition in Small Mammals

Challis¹,

Nathanielsz²

1979

Human Parturition

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Uterine Control of Ovarian Function

Cited by 9 publications

References 374 publications

Phytochemical analysis and beneficial effects of Artemisia absinthium L. essential oil in rat pseudopregnancy model

Phytochemical analysis and beneficial effects of Artemisia absinthium L. essential oil in rat pseudopregnancy model

The effects of pelvic neurectomy on collagen in the cervix of the pseudopregnant rat

Parturition in Small Mammals

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