Uterine corpus metastasis in stage IA1 squamous carcinoma of the cervix

McCormick, Aiste; Cross, Paul; Edmondson, Richard J.

doi:10.1016/j.gynor.2013.07.006

Cited by 1 publication

(3 citation statements)

References 12 publications

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“…The possible characteristics that increase metastasis include age > 45 years, histological type of squamous cell carcinoma, uterine involvement and lymphatic invasion [ 10 ]. It was seldom reported that early-stage CSCC could also metastasize to the ovary [ 9 – 14 ], although Shimada M et al suggested that FIGO stage was not significant in patients with ovarian metastasis [ 4 ]. In those reports, most ovarian metastases in CSCC were in early stage IA2–IIB [ 4 , 10 , 11 , 13 ], and only one case was in stage IA1, with one carcinoma in situ.…”

Section: Discussionmentioning

confidence: 99%

“…However, those metastasis focuses were tiny and superficial. One case had only minimal foci in the endometrium, the fallopian and ovary were normal, and there was no evidence of LVSI [ 14 ]. Other cases of ovarian metastasis could only be observed under a microscope on the ovarian surface.…”

Section: Discussionmentioning

confidence: 99%

“…Other cases of ovarian metastasis could only be observed under a microscope on the ovarian surface. In China, there is only one report about superficial invasion of CSCC metastasized to the ovarian endometriotic cyst wall [ 14 ]. Although the report said cervical carcinoma in situ could also metastasize to the ovary surface in very local areas [ 9 ], our patient belonged to this early stage, but their cancer had metastasized to the ovary with a huge mass.…”

Section: Discussionmentioning

confidence: 99%

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Stage IA1 HPV-associated cervical squamous cell carcinoma metastasizing to ovary by special pathway: a case report and literature review

Zhang

Wang

et al. 2022

J Ovarian Res

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Background As the leading cancer of the female reproductive tract, it is not uncommon for human papilloma virus (HPV)-associated cervical squamous cell carcinoma (HPV-CSCC) to metastasize to pelvic organs and lymph nodes in advanced stages. However, herein, we present a rare case in which superficial invasive HPV-CSCC metastasized to the unilateral ovary as a large mass by spreading directly through the endometrium and fallopian tubes and lymph-vascular space invasion. The case is so unexpected that the misdiagnosis most likely could be proceeded as a primary ovarian cancer. Case presentation A 58-year-old postmenopausal woman presented vaginal bleeding for more than 4 months, never received hormonal treatment and had no family history of malignant diseases. Routine ultrasound revealed a 12 × 10 × 10 cm right ovarian mass. Intraoperative frozen section was diagnosed as a borderline Brenner tumour with local highly suspected invasive carcinoma. Accordingly, omentectomy surgery then occurred. Unbelievably, by observation under a microscope, immunohistochemistrial staining, and HPV RNA scope, we found that the carcinoma originated from the uterine cervix. In the uterine cervix, stage IA1 superficial invasive squamous carcinoma was found, and the carcinoma directly spread to the endometrium and bilateral fallopian tube, was planted into the right ovary and eventually grew as a large mass. Moreover, lymph-vascular space invasion (LVSI) was also discovered. To date, the patient has been given 6 cycles of chemotherapy and has experienced no recurrence. Conclusions The diagnosis of superficial invasive cervical squamous cell carcinoma metastasizing to the ovary is very challenging for pathological doctors, especially in intraoperative consultations.

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