Uterine enzyme changes in thyroidectomized rats at parturition

Rao, P. Mallikarjuna; Panda, J. N.

doi:10.1530/jrf.0.0610109

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Also, an enhanced response to hCG with development of large cystic ovaries-but few corpus lutea-was also described in hypothyroid rats (117). In mature female rats, hypothyroidism did not result in sterility but interfered with gestation, especially in its first half, with resorption of the embryo and subsequent reduction in litter size and increase in stillbirths (118,119). Ruh et al (111) reported increased E 2 binding to the uteri of hypothyroid rats, a finding that was not confirmed by others (120).…”

Section: The Effects Of Thyrotoxicosis and Hypothyroidism On The Femamentioning

confidence: 94%

Thyroid Function and Human Reproductive Health

Krassas¹,

2010

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Via its interaction in several pathways, normal thyroid function is important to maintain normal reproduction. In both genders, changes in SHBG and sex steroids are a consistent feature associated with hyper- and hypothyroidism and were already reported many years ago. Male reproduction is adversely affected by both thyrotoxicosis and hypothyroidism. Erectile abnormalities have been reported. Thyrotoxicosis induces abnormalities in sperm motility, whereas hypothyroidism is associated with abnormalities in sperm morphology; the latter normalize when euthyroidism is reached. In females, thyrotoxicosis and hypothyroidism can cause menstrual disturbances. Thyrotoxicosis is associated mainly with hypomenorrhea and polymenorrhea, whereas hypothyroidism is associated mainly with oligomenorrhea. Thyroid dysfunction has also been linked to reduced fertility. Controlled ovarian hyperstimulation leads to important increases in estradiol, which in turn may have an adverse effect on thyroid hormones and TSH. When autoimmune thyroid disease is present, the impact of controlled ovarian hyperstimulation may become more severe, depending on preexisting thyroid abnormalities. Autoimmune thyroid disease is present in 5-20% of unselected pregnant women. Isolated hypothyroxinemia has been described in approximately 2% of pregnancies, without serum TSH elevation and in the absence of thyroid autoantibodies. Overt hypothyroidism has been associated with increased rates of spontaneous abortion, premature delivery and/or low birth weight, fetal distress in labor, and perhaps gestation-induced hypertension and placental abruption. The links between such obstetrical complications and subclinical hypothyroidism are less evident. Thyrotoxicosis during pregnancy is due to Graves' disease and gestational transient thyrotoxicosis. All antithyroid drugs cross the placenta and may potentially affect fetal thyroid function.

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Section: The Effects Of Thyrotoxicosis and Hypothyroidism On The Femamentioning

confidence: 94%

Thyroid Function and Human Reproductive Health

Krassas¹,

2010

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“…Hypothyroidism in hamsters and cows is associated with abnormal estrous cycles, 96,97 and in hypothyroid hens there is a decrease in egg production 97. In the mature female rat, hypothyroidism apparently does not result in sterility but does interfere with gestation, especially in the first half of pregnancy, 98 with resorption of the embryo and subsequent reduction in litter size and an increase in stillbirths 99…”

Section: Experimental Datamentioning

confidence: 99%

The Hypothalamic‐Pituitary‐Thyroid Axis and the Female Reproductive System

Doufas

Mastorakos

2000

Annals of the New York Academy of Sciences

145

107

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Increasing evidence derived from experimental and clinical studies suggests that the hypothalamic-pituitary-thyroid axis (HPT) and the hypothalamic-pitutitary-ovarian axis (HPO) are physiologically related and act together as a unified system in a number of pathological conditions. The suggestion that specific thyroid hormone receptors at the ovarian level might regulate reproductive function, as well as the suggested influence of estrogens at the higher levels of the HPT axis, seems to integrate the reciprocal relationship of these two major endocrine axes. Both hyper-and hypothyroidism may result in menstrual disturbances. In hyperthyroidism the most common manifestation is simple oligomenorrhea. Anovulatory cycles are very common. Increased bleeding may also occur, but it is rare. Hypothyroidism in girls can cause alterations in the pubertal process; this is usually a delay, but occasionally it can result in pseudoprecocious puberty. In mature women hypothyroidism usually is associated with abnormal menstrual cycles characterized mainly by polymenorrhea, especially anovulatory cycles, and an increase in fetal wastage.

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Biochemical response of the mussel Mytilus coruscus (Mytiloida: Mytilidae) exposed to in vivo sub-lethal copper concentrations

Gu²,

Liu

et al. 2012

Chin. J. Ocean. Limnol.

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Uterine enzyme changes in thyroidectomized rats at parturition

Cited by 4 publications

References 18 publications

Thyroid Function and Human Reproductive Health

Thyroid Function and Human Reproductive Health

The Hypothalamic‐Pituitary‐Thyroid Axis and the Female Reproductive System

Biochemical response of the mussel Mytilus coruscus (Mytiloida: Mytilidae) exposed to in vivo sub-lethal copper concentrations

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