Uterine Epithelioid Angiosarcoma on F-18 FDG PET/CT

Abstract

Uterine epithelioid angiosarcoma can have conventional imaging characteristics similar to those of other uterine tumors, such as leiomyoma, leiomyosarcomas or hemangioendothelioma. Uterine epithelioid angiosarcoma exhibiting increased fluorine-18 fluorodeoxyglucose (F-18 FDG) activity can be misdiagnosed. A 61-year-old woman who was diagnosed with uterine epithelioid angiosarcoma underwent F-18 FDG positron emission tomography/computed tomography (PET/CT) as a part of the pretreatment work up for surgery. F-18 FDG PET/CT showed an intense F-18 FDG uptake in the uterus in addition to increased F-18 FDG uptake at the paraaortic and aortocaval lymph nodes. To our knowledge, this is the first case report of intense F-18 FDG uptake in uterine epithelioid angiosarcoma in Korea.

Multifocal gastrointestinal epithelioid angiosarcomas diagnosed by endoscopic mucosal resection: A case report

“…This innate characteristic of epithelioid angiosarcoma corresponds to the tendency of gastrointestinal bleeding. PET/CT has been reported to detect primary uterine and pulmonary epithelioid angiosarcoma[ 15 , 16 ] and is of great value in identifying metastases.…”

The Impact of Radiation on an Unusual Case of Omental Epithelioid Angiosarcoma

“…Typically, epithelioid angiosarcomas have characteristic pathologic features such as irregular vascular channels with adjacent atypical pleomorphic epithelioid cells [ 5 ]. These tumors contain many mitotic figures as well as nuclear atypia and patchy areas of hemorrhagic necrosis [ 1 , 5 , 6 ].…”

“…Typically, epithelioid angiosarcomas have characteristic pathologic features such as irregular vascular channels with adjacent atypical pleomorphic epithelioid cells [ 5 ]. These tumors contain many mitotic figures as well as nuclear atypia and patchy areas of hemorrhagic necrosis [ 1 , 5 , 6 ]. Epithelioid angiosarcomas stain strongly positive for Vimentin and in most cases are immunoreactive for vascular markers CD31, CD34, and VEGFR-3 and Factor VIII [ 1 , 7 – 9 ].…”

F-18 fluorodeoxyglucose positron emission tomography for differential diagnosis and prognosis prediction of vascular tumors

“…AS lesions were FDG-avid (4–8); therefore, response to chemotherapy was able to be successfully monitored using FDG-PET (4,7). However, the usefulness of FDG-PET in the management of AS is not clear, as only case reports are available in the literature.…”

“…F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to detect AS in a variety of regions, such as the scalp ( 4 ), cardiac right atrium ( 5 ), liver ( 6 ), extremities ( 7 ) and uterus ( 8 ). AS lesions were FDG-avid ( 4 – 8 ); therefore, response to chemotherapy was able to be successfully monitored using FDG-PET ( 4 , 7 ). However, the usefulness of FDG-PET in the management of AS is not clear, as only case reports are available in the literature.…”