Uterine fibroids: risk of recurrence after myomectomy in a Nigerian population

Jy, Obed; Bako, Babagana; Usman, Joshua; Moruppa, J. Y.; Kadas, Saidu

doi:10.1007/s00404-010-1355-y

Cited by 16 publications

(12 citation statements)

References 14 publications

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“…Only 3.1% had recurrence during the follow-up period, which is much lower than 20.7% reported earlier in the same center among all patients 20. This is because of the decline in ovarian function toward the later part of the reproductive age and the consequent hypoestrogenic state that ensues.…”

Section: Discussionmentioning

confidence: 54%

The benefit of myomectomy in women aged 40 years and above: Experience in an urban teaching hospital in Nigeria

Bako

Kadas

et al. 2011

Niger Med J

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Background:Abdominal myomectomy remains the mainstay of surgical management of uterine fibroids in our environment. However, its benefit in women aged 40 years and above remains debatable.Materials and Methods:An 11-year prospective study was conducted involving 98 women, aged 40 years and above, who had abdominal myomectomy for the treatment of uterine fibroid at the University of Maiduguri Teaching Hospital, Maiduguri. They were followed up regularly for 1–6 years to detect conception, resolution of symptoms and obstetrics performance. Data were analyzed using SPSS version 13.Results:The mean age of the patients was 42.6±2.9 years and 77 (78.6%) of them were nulliparous. Lower abdominal swelling was the commonest clinical presentation and the mean uterine size was 18.6±8.5 weeks. Infertility with uterine fibroids was the indication for myomectomy in majority of the cases [48 (48.9%)], while pregnancy complications accounted for 11.2% (11) of the cases Fertility restoration was 10.4% among the infertile patients. There was complete resolution of symptoms in 35.9% of those who required symptomatic relief, and term pregnancies were recorded in 72.7% of patients with pregnancy complications.Conclusion:Myomectomy is the recommended treatment of uterine fibroids in women aged 40 years and above with infertility and who wish to become pregnant. If there is no need for further fertility preservation, hysterectomy should be offered.

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Section: Discussionmentioning

confidence: 54%

The benefit of myomectomy in women aged 40 years and above: Experience in an urban teaching hospital in Nigeria

Bako

Kadas

et al. 2011

Niger Med J

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“…Nishiyama et al [6] reported an increased risk of recurrence among patients with four or more leiomyomas [6]. Another study found that the risk of recurrence after multiple myomectomies was increased by 3.14‐fold [13]. This relationship might be explained by the surgical difficulty experienced in the removal of multiple leiomyomas or it could be a result of increased potential of the myometrium to produce leiomyoma [4].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies clearly defined the relationship between the number of leiomyomas removed and recurrence rates [6,7,9,12,13]. Two studies reported lowered recurrence rates after myomectomy among patients with one leiomyoma [9,11].…”

Section: Discussionmentioning

confidence: 99%

Clinical and histopathologic predictors of reoperation due to recurrence of leiomyoma after laparotomic myomectomy

Şükür

Kankaya

Ateş

et al. 2014

Intl J Gynecology & Obste

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“…Several studies have reported that recurrence of multiple uterine leiomyomas (MUL) occurs at higher rates than solitary uterine leiomyoma (SUL) (2)(3)(4). Moreover, clinical observation and epidemiology showed that SUL tended to grow in a larger diameter and rarely developed into multiple tumours.…”

Section: Introductionmentioning

confidence: 99%

MiR-142-3p May Be Involved in the Development of Solitary and Multiple Uterine Leiomyomasby Interacting with CTNNB1 and AXIN-2 Through Wnt Signaling Pathway

Yang

Gou

et al. 2020

Preprint

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Background The pathogenesis and clinical behaviors between solitary uterine leiomyoma (SUL) and multiple uterine leiomyomas (MUL) vary, which lead to the difference in management for childbearing-aged patients. Herein, we aim to find the potential miRNAs involved in the development of SUL and MUL. Results The top 5 differentially expressed miRNAs, Wnt signalling pathway and its two central molecules APC and CTNNB1 were screened out according to microarray analysis and bioinformatics. MiR-142-3p was selected for further exploration. In validation of qRT-PCR, MiR-142-3p was significantly upregulated in SUL, while downregulated in MUL, CTNNB1 and sequencing target AXIN-2 were expressed at higher level in MUL than SUL. Overexpression of MiR-142-3p resulted in lower transcription level of CTNNB1 and AXIN-2, and lower cell proliferation level. Conclusions MiR-142-3p may be involved in the development of SUL and MUL by interacting with CTNNB1 and AXIN-2 through Wnt signaling pathway. MiR-142-3p could serve as a potential biomarker for individualized treatment between SUL and MUL in the future.

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Uterine fibroids: risk of recurrence after myomectomy in a Nigerian population

Abstract: There is a high recurrence of uterine fibroid after myomectomy in our environment. The risk is higher among women with positive family history, multiple uterine fibroids, and in those with multiple symptoms. Pregnancy and use of OCP are protective.

Cited by 16 publications

References 14 publications

The benefit of myomectomy in women aged 40 years and above: Experience in an urban teaching hospital in Nigeria

The benefit of myomectomy in women aged 40 years and above: Experience in an urban teaching hospital in Nigeria

Clinical and histopathologic predictors of reoperation due to recurrence of leiomyoma after laparotomic myomectomy

MiR-142-3p May Be Involved in the Development of Solitary and Multiple Uterine Leiomyomasby Interacting with CTNNB1 and AXIN-2 Through Wnt Signaling Pathway

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Uterine fibroids: risk of recurrence after myomectomy in a Nigerian population

Abstract: There is a high recurrence of uterine fibroid after myomectomy in our environment. The risk is higher among women with positive family history, multiple uterine fibroids, and in those with multiple symptoms. Pregnancy and use of OCP are protective.

Cited by 16 publications

References 14 publications

The benefit of myomectomy in women aged 40 years and above: Experience in an urban teaching hospital in Nigeria

The benefit of myomectomy in women aged 40 years and above: Experience in an urban teaching hospital in Nigeria

Clinical and histopathologic predictors of reoperation due to recurrence of leiomyoma after laparotomic myomectomy

MiR-142-3p May Be Involved in the Development of&nbsp;Solitary and Multiple Uterine Leiomyomasby Interacting with CTNNB1 and AXIN-2 Through Wnt Signaling Pathway

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MiR-142-3p May Be Involved in the Development of Solitary and Multiple Uterine Leiomyomasby Interacting with CTNNB1 and AXIN-2 Through Wnt Signaling Pathway