Uterine Histo‐pathology in Patients Fitted With Plastic Intrauterine Contraceptive Devices

Buckle, A. E. R.; Barnett, H.

doi:10.1111/j.1471-0528.1966.tb06128.x

Cited by 15 publications

(2 citation statements)

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“…The failure to find leukocytes in every uterus by this technique has been interpreted to mean that inflammation is not a significant part of the response to a foreign body in the human uterus (23). Recent studies, however, which utilized whole human uteri, found that leukocytes were always present in the tissue that was in contact with the foreign body (24)(25)(26). This suggests that inflammation is limited to the region of the foreign body in the human uterus, and that the absence of leukocytes in many biopsy specimens is a consequence of random sampling.…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Polymorphonuclear Leukocytes to Infertility in Uteri Containing Foreign Bodies

Parr

Schaedler

Hirsch

1967

The Journal of Experimental Medicine

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The intrauterine contraceptive device is a potentially important factor in the world population problem, primarily became it provides an effective method of contraception that does not require continuous motivation on the part of the user. In addition, its cost is trivial, its insertion requires only a few minutes, and normal fertility returns quickly after its removal. There is also some reason (1, 2) to hope that the difficulties in its use, such as expulsions and rare pregnancies, can be overcome, since we still have much to learn about it. Even the basis of its contraceptive action remains unknown.Previous observations in the rat and other species indicated that a foreign body in the uterus had no systemic effect, but only a local effect in the uterus. This local effect in the uterus appeared to be a direct toxicity for blastocysts or spermatozoa, rather than an inhibition of implantation. For example, a foreign body in the rat uterus (3, 4) had no effect on fertilization or tubal transport of ova, but a few hours after blastocysts entered the horn containing a foreign body they could no longer be recovered; blastocysts could be recovered from control horns for about 24 hr. Thus, in the rat horn containing a foreign body, blastocysts were no longer present at the time of implantation. In the mouse (5), similar observations were made, and in addition it was noted that spermatozoa were killed. In the sheep (6), spermatozoa were killed in the uterus and fertilization was prevented. And in the rabbit (7), pregnancy occurred throughout the uterus except for the portion in direct contact with the foreign body. Observations such as these have led to the notion that a foreign body creates a hostile environment in the uterus (8). The experiments reported here clarify the role of inflammation and of infection in the infertility of uteri containing a foreign body. fig. 1 is a diagram of the rodent uterus, detailing the regions of special interest in these studies. The region FB (foreign body) was the segment of the uterine horn which contained Materials and Methods Text-

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Section: Discussionmentioning

confidence: 99%

The Relationship of Polymorphonuclear Leukocytes to Infertility in Uteri Containing Foreign Bodies

Parr

Schaedler

Hirsch

1967

The Journal of Experimental Medicine

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“…Unser Bericht betrifft die morphologischen Veränderungen, die auf lange Sicht gesehen mehr oder minder irreparable Schädigungen am Endometrium oder Myo metrium hervorrufen oder einleiten können. In den letzten Jahren wurde eine ganze Reihe ausgezeichneter Arbeiten über die morphologischen Veränderungen am Endometrium als Folge der Applikation von IUCD veröffentlicht [3,6,8,9,11,14].…”

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Pathologische Veränderungen am Endometrium und Myometrium durch intrauterine Kontrazeptiva

Janovski¹,

Russo²

1968

Gynäkol Geburtshilfliche Rundsch

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Intrauterine contraceptive devices: Present status and future prospects

Davis

1972

American Journal of Obstetrics and Gynecology

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Uterine Histo‐pathology in Patients Fitted With Plastic Intrauterine Contraceptive Devices

Cited by 15 publications

References 1 publication

The Relationship of Polymorphonuclear Leukocytes to Infertility in Uteri Containing Foreign Bodies

The Relationship of Polymorphonuclear Leukocytes to Infertility in Uteri Containing Foreign Bodies

Pathologische Veränderungen am Endometrium und Myometrium durch intrauterine Kontrazeptiva

Intrauterine contraceptive devices: Present status and future prospects

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