Uterine Involution and Fertility of Holstein Cows Subsequent to Early Postpartum PGF2α Treatment for Acute Puerperal Metritis

Abstract

The objective was to evaluate the effect of 2 doses of PGF(2alpha) injected early postpartum on uterine involution, serum concentration of acute phase proteins at 12 d postpartum, and fertility in Holstein cows with acute puerperal metritis. Only cows diagnosed with retained fetal membranes and metritis and treated with ceftiofur hydrochloride for 5 d were used in the study. Two hundred cows were assigned randomly to be treated (n = 100) or to serve as controls (n = 100). Treatment consisted of 2 i.m. injections of PGF(2alpha) 8 h apart on d 8 postpartum. A subsample of 90 cows was selected randomly (45 treated cows; 45 controls) to evaluate uterine diameter using ultrasonography, uterine score, and serum concentrations of acute phase proteins at 12 d postpartum. The outcome variable for all cows was conception rate at first service. Postpartum, primiparous, treated cows had smaller uterine diameters and lower uterine scores than controls. Cows with a uterine diameter <5.1 cm at 12 d postpartum were 5.5 times more likely to conceive at first service than cows with larger uterine horn diameter. Treatment significantly reduced the concentrations of serum alpha1-acid glycoprotein. Within primiparous cows, treatment also increased conception at first service by 17%. It was concluded that 2 doses of PGF(2alpha) 8 h apart at 8 d postpartum in primiparous cows with acute puerperal metritis decreased the diameter of uterine horns and serum concentration of alpha1-acid glycoprotein at 12 d postpartum and increased the conception rate at first service.

Ultrasonographic reproductive tract measures and pelvis measures as predictors of pregnancy failure and anestrus in restricted bred beef heifers

“…The difference in UD between the two birth cohorts in this study may have occurred as a result of a true biological difference in the younger group of heifers in 2008 [19], or may have been a systematic measuring error that occurred during sampling [34].…”

Administration of PGF2α and Antibiotic in Dairy Cows during Early Postpartum Period and Their Effect on Various Fertility Parameters

“…During early postpartum period, exogenous PGF 2 α administration can increase the rate of uterine involution which results in evacuation of bacterial contamination from the uterus and subsequently improve conception rate (Nanda et al, 2003). Contrarily, administration of PGF 2 α during the early postpartum phase was associated with improvement in fertility (Pankowski et al, 1995;Melendez et al, 2004). However, the mean number of inseminations required for conception were less (1.33±0.21) in antibiotic group while in PG8, PG25 and control group, these were 1.50±0.22, 1.50±0.22 and 1.66±0.21, respectively.…”

Effects of the Treatment Method of Reproductive Performance in Cows with Retention of Fetal Membranes

“…It should be mentioned that metritis affected cows were not administered PGF 2α injection on the day 8 PP. Melendez et al (2004) mentioned that in the first seven days postpartum, the PFG 2α level in blood in cows with RFM and metritis…”