Uterine Leiomyomata

Wise, Lauren A.; Laughlin-Tommaso, Shannon K.

doi:10.1016/b978-0-12-384978-6.00019-4

Cited by 26 publications

(30 citation statements)

References 205 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most studies of genetic polymorphisms in relation to UL have focused on genes involved in steroidogenesis because studies suggest endogenous sex hormones are important in the development and progression of disease. However, candidate gene studies have produced inconsistent findings, which may be attributable to small sample size and inadequately-characterized study populations [186]. The first ever genome-wide association study (GWAS) of UL was conducted in a Japanese population [187], finding three significant loci on chromosomes 10q24.33, 22q13.1 and 11p15.5.…”

Section: Etiologic Hypotheses and Risk Factorsmentioning

confidence: 99%

Epidemiology of Uterine Fibroids

Wise

Laughlin-Tommaso

2016

Clinical Obstetrics &Amp; Gynecology

Self Cite

278

122

View full text Add to dashboard Cite

Uterine leiomyomata (UL) have a substantial impact on women's health, but relatively few studies have identified opportunities for primary prevention of these neoplasms. Most established risk factors are not modifiable, including premenopausal age, African ancestry, age at menarche, and childbearing history. The main challenge in studying UL is that a large proportion of tumors are asymptomatic. Herein, we review the epidemiology of UL from published studies to date. We highlight the advantages of ultrasound screening studies and the ways in which their innovative methods have helped clarify the etiology of disease. We conclude with a discussion of promising new hypotheses.

show abstract

Section: Etiologic Hypotheses and Risk Factorsmentioning

confidence: 99%

Epidemiology of Uterine Fibroids

Wise

Laughlin-Tommaso

2016

Clinical Obstetrics &Amp; Gynecology

Self Cite

278

122

View full text Add to dashboard Cite

show abstract

“…The only well-replicated risk factors are increased age (up to age of menopause), African American ethnicity, earlier age of menarche, and nulliparity. 12 The prospective investigations of new clinical diagnoses of fibroids in the Nurses' Health Study 13 and the Black Women's Health Study 14 have both contributed important epidemiologic information (reviewed by Laughlin et al 12 and Wise and Laughlin-Tommaso 15 ), but the disease outcome in those studies is clinical diagnosis of fibroids. The actual time of disease onset is unknown because tumors may be present for years before they are clinically diagnosed.…”

Section: Introductionmentioning

confidence: 99%

A Prospective, Ultrasound-Based Study to Evaluate Risk Factors for Uterine Fibroid Incidence and Growth: Methods and Results of Recruitment

Baird

Harmon

Upson

et al. 2015

Journal of Women's Health

View full text Add to dashboard Cite

Background: Uterine fibroids are common, benign, smooth-muscle tumors that can cause major morbidity for reproductive-age women, often requiring invasive treatment. Despite this personal and public health burden, no prior study has attempted to periodically screen fibroid-free women with ultrasound to detect incident disease and identify risk factors. Methods: We designed a study to prospectively investigate development of fibroids by enrolling women without a clinical diagnosis of fibroids and screening for fibroids with ultrasound at baseline. Enrollment procedures included extensive questionnaires and specimen collection (blood, urine, vaginal swabs). The cohort is followed at approximately 20-month intervals. At each follow-up there are updates to the questionnaire data, further specimen collection, and an ultrasound examination. We identify incident disease and measure tumor growth. The two exposures of primary interest are vitamin D insufficiency and reproductive tract infections. This manuscript provides a detailed description of the study methods, recruitment results, and participant characteristics. Results: The Study of Environment, Lifestyle and Fibroids enrolled 1,696 African American women aged 23-34 years. ''Family and friends'' was a leading recruitment source. More than 95% of participants contributed all the requested biological specimens at baseline. Study ultrasound examinations revealed undiagnosed fibroids in 378 women (22% of participants). The retention rate for the first follow-up was 87%. Conclusions: Study design aspects likely to be important for long-term studies in young African Americans include personalized recruitment, multiple steps to the enrollment process that rely on the initiative of the participant, and methods for tracing highly mobile study subjects.

show abstract

“…Studies have documented a 2–3-fold higher incidence of UL in African Americans than European Americans (4, 5), and African Americans tend to have younger ages at diagnosis and greater symptom severity (6). None of the identified established risk factors explain this racial disparity (7). …”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in vitamin D–related genes and risk of uterine leiomyomata

Wise

Ruiz-Narváez

Haddad

et al. 2014

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

Objective To investigate UL incidence in relation to polymorphisms in genes involved in vitamin D metabolism and skin pigmentation. Rates of uterine leiomyomata (UL) are 2–3 times higher in African Americans than European Americans. Recent studies suggest that vitamin D deficiency is associated with an increased risk of UL. Design Nested case-control study. Setting Black Women’s Health Study, a prospective cohort study of African American women. Patient(s) 2,232 premenopausal women diagnosed with UL confirmed by ultrasound or surgery during 1997–2011 (cases) and 2,432 premenopausal women never diagnosed with UL through 2011 (controls). Intervention None. Main outcome measure Self-reported UL. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between each polymorphism and UL, controlling for age, geographic region, and ancestry. Results Three of twelve polymorphisms were associated with UL at the nominal significance level: rs4944957 and rs12800438 near DHCR7, and rs6058017 in ASIP. After correction for multiple hypothesis testing, two SNPs remained significantly associated with UL (rs12800438 and rs6058017). Compared with the AA genotype for rs12800438 (correlated with higher serum 25(OH)D levels), ORs were 1.09 (95% CI: 0.92, 1.29) and 1.23 (95% CI: 1.03, 1.47) for the GA and GG genotypes, respectively. Compared with the AA genotype for rs6058017 (correlated with higher serum 25(OH)D levels), ORs were 1.01 (95% CI: 0.83, 1.22) and 1.18 (95% CI: 0.97, 1.44) for the GA and GG genotypes, respectively. Conclusions Our data support the hypothesis that vitamin D deficiency is involved in UL etiology.

show abstract

Uterine Leiomyomata

Cited by 26 publications

References 205 publications

Epidemiology of Uterine Fibroids

Epidemiology of Uterine Fibroids

A Prospective, Ultrasound-Based Study to Evaluate Risk Factors for Uterine Fibroid Incidence and Growth: Methods and Results of Recruitment

Polymorphisms in vitamin D–related genes and risk of uterine leiomyomata

Contact Info

Product

Resources

About