Uterine Metabolomics Reveals Protection of Taohong Siwu Decoction Against Abnormal Uterine Bleeding

Zhang, Yanyan; Zuo, Chijing; Han, Lei; Liu, Xiaochuang; Chen, Weidong; Wang, Jichen; Gui, Shuangying; Peng, Can; Peng, Daiyin

doi:10.3389/fphar.2020.507113

Cited by 9 publications

(6 citation statements)

References 64 publications

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“…The inheritance and innovation of modern physicians has widely used THSWD in the treatment of various systems throughout the body, and has been widely used in TCM clinics. THSWD is traditionally used in gynecology, the effective rate of treating primary dysmenorrhea is more than 90% [ 20 ], and it can be used for postpartum blood stasis [ 21 ], uterine bleeding [ 22 ], etc. It is widely used in internal medicine such as coronary heart disease [ 23 , 24 ], ischemic stroke [ 25 ], etc.…”

Section: Introductionmentioning

confidence: 99%

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Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction

Jiang

et al. 2021

Chin Med

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The high incidence of breast cancer is the greastest threat to women’ health all over the world. Among them, HER-2 positive breast cancer has the characteristics of high malignancy, easy recurrence and metastasis, and poor prognosis. Traditional Chinese medicine (TCM) has a rich theoretical basis and clinical application for breast cancer. TCM believes that blood stasis syndrome is one of the important pathogenesis of breast formation and development. Taohong Siwu Decoction (TSHWD) is based on the “First Prescription of Gynecology” Siwu Decoction. It is widely used in various blood stasis and blood deficiency syndromes, mainly in gynecological blood stasis. Clinical studies have found that THSWD can treat breast cancer by reducing blood vessel and lymphangiogenesis with auxiliary chemotherapy. In this study, we aim to explore the material basis and mechanism of THSWD in the treatment of HER-2 positive breast cancer through literature review and network pharmacology studies. Through a literature review of the traditional application, chemical composition of Chinese herbal medicine of THSWD, as well as its clinical reports and pharmacological research on breast cancer treatment. Meanwhile, we conducted “component-pathway-target” network through network pharmacology reveals the main material basis, possible targets and pathways of THSWD in inhibiting HER-2 positive breast cancer. Literature review and network pharmacology research results had predicted that, baicalein, kaempferol, caffeic acid, amygdalin, quercetin, ferulic acid, gallic acid, catalpol, hydroxysafflor yellow A, paeoniflorin in THSWD are the main effective chemical composition. THSWD regulates 386 protein targets and 166 pathways related to breast cancer. The molecular mechanism is mainly to improve the microenvironment of tumor cells, regulate the process of tumor cell EMT, and inhibit tumor cell proliferation and metastasis. This study revealed the mechanism of action of THSWD in the treatment of HER-2 positive breast cancer through literature review and network pharmacology studies, providing a scientific basis for clinical application.

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Section: Introductionmentioning

confidence: 99%

“…It is mainly used to treat many gynecological diseases caused by blood deficiency and blood stasis, such as dysmenorrhea, breast hyperplasia, ovarian cysts, menopausal syndrome, etc. [ 20 , 22 ]. Clinical studies have found that THSWD can treat breast cancer by reducing blood vessel and lymphangiogenesis with auxiliary chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction

Jiang

et al. 2021

Chin Med

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“…The LS-MS results showed that TWS decoction contained ferulic acid and amygdalin, and their relative peak areas were 1,562,890 and 33,370, respectively. Previous studies indicated that the main active ingredients of TSW decoction were ferulic acid, paeoniflorin, amygdalin, hydroxysafflor yellow A, catalpol, and gallic acid [ 26 , 27 ]. Therefore, we speculated that the main active components of TSW decoction were ferulic acid and amygdalin.…”

Section: Resultsmentioning

confidence: 99%

Taohong Siwu-Containing Serum Enhances Angiogenesis in Rat Aortic Endothelial Cells by Regulating the VHL/HIF-1α/VEGF Signaling Pathway

Tang

Xie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. The incidence of bone fracture and bone-related diseases is increasing every year. Angiogenesis plays a vital role in fracture healing and bone repair. This study assessed the benefits of Taohong Siwu (TSW) decoction on angiogenesis in isolated rat aortic endothelial cells (RAEC) treated with TSW-containing serum. Methods. The components of TSW decoction were analyzed by liquid chromatography-mass spectrometry (LC-MS). TSW-containing serum was prepared by gavage of TSW decoction to Sprague-Dawley (SD) rats. The effects of TSW-containing serum on the viability, migration, wound healing, and angiogenesis of RAEC were detected by the MTT, transwell, wound healing, and Matrigel lumen formation assays, respectively. In addition, the effects of an HIF-1α inhibitor on TSW-containing serum-induced RAEC were also assessed. The effects of TSW-containing serum on the expression of the HIF-1α signaling pathway were evaluated by qRT-PCR and western blot analysis. Results. LC-MS revealed that TSW decoction primarily contained isomaltulose, choline, D-gluconic acid, L-pipecolic acid, hypotaurine, albiflorin, and tryptophan. TSW-containing serum significantly increased the viability, migration, wound healing, and angiogenesis of RAEC in a dose-dependent manner. Furthermore, our results demonstrated that HIF-1α and VEGF expressions were increased in the cells of TSW-containing serum groups, whereas VHL expression was decreased. The effects of TSW-containing serum were reversed by treatment with an HIF-1α inhibitor. Conclusion. These results suggested that TSW decoction enhanced angiogenesis by regulating the VHL/HIF-1α/VEGF signaling pathway.

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“…TCM compounds have multi-target and multi-pathway biological effects. As a traditional classic prescription, THSWD is currently widespread in the elds of internal medicine, surgery, gynecology, and orthopedics [10,11]. It is widely used in clinical practice for cardiovascular diseases [12], osteoporosis and bone fracture [13][14][15][16] and exhibits excellent therapeutic effects.…”

Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatics, Network Pharmacology and Molecular Docking to Explore the Mechanisms of Taohong Siwu Decoction in the Treatment of Tendinopathy

Li,

Pan

2024

Preprint

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Objective: This study aims to investigate the potential mechanism of Taohong Siwu Decoction (THSWD) in the treatment of tendinopathy using bioinformatics, network pharmacology, and molecular docking methods. Methods: The human tendinopathy expression microarray dataset was obtained from the GEO database. Bioinformatics methods were employed to screen differentially expressed genes. Disease-associated genes related to tendinopathy were identified using relevant databases. Potential targets of THSWD for treating tendinopathy were identified and subjected to functional and pathway enrichment analysis. A protein-protein interaction (PPI) network of potential therapeutic targets was constructed, along with a drug components-disease target-signaling pathway network. Results: A total of 867 tendinopathy-related targets were confirmed, while 45 active ingredients of THSWD resulted in retrieval of 216 corresponding tendinopathy targets. THSWD primarily modulates signaling pathways such as IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway associated with diabetic complications, as well as other signaling pathways for effective treatment of tendinopathy. Molecular docking simulations demonstrated high binding activity between core active compounds and hub genes. Conclusion: The therapeutic effect of THSWD on tendinopathy is achieved through a multi-component, multi-target, and multi-pathway approach involving primarily the IL-17 signaling pathway, TNF signaling pathway, and AGE-RAGE signaling pathway in diabetic complications.

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Uterine Metabolomics Reveals Protection of Taohong Siwu Decoction Against Abnormal Uterine Bleeding

Cited by 9 publications

References 64 publications

Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction

Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction

Taohong Siwu-Containing Serum Enhances Angiogenesis in Rat Aortic Endothelial Cells by Regulating the VHL/HIF-1α/VEGF Signaling Pathway

Integrated Bioinformatics, Network Pharmacology and Molecular Docking to Explore the Mechanisms of Taohong Siwu Decoction in the Treatment of Tendinopathy

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