Uterine metastasis from invasive ductal breast carcinoma: A case report with literature review

Bouvier, Anne‐Sophie; Panchbhaya, Nabilah; Brochard, Camille; Marchand, E.; Mezzadri, M.; Leveau-Vallier, Anne-Sophie; Cornélis, F.; Bénifla, Jean-Louis; Mimoun, Camille

doi:10.1016/j.jogoh.2020.101993

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…16 Lesions of BIDC display a large amount of dense fibrous tissue proliferation, high interstitial density, and infiltrative growth of interstitial cancer cells, which are adhered to the surrounding normal tissues. 17,18 Thus, these factors increase the hardness, while lesions of FBC contain more mucopolysaccharide components and lax structures. Hence, BIDC lesions are significantly harder than nodular FBC lesions.…”

Section: Discussionmentioning

confidence: 99%

Application Value of Ultrasound Elastography Combined With Contrast-Enhanced Ultrasound (CEUS) Quantitative Analysis in Differentiation of Nodular Fibrocystic Changes of the Breast From Invasive Ductal Carcinoma

Li,

Wu,

Tian

et al. 2023

Ultrason Imaging

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This study aimed to compare the value of ultrasound elastography combined with contrast-enhanced ultrasound (CEUS) quantitative analysis in the differentiation of nodular fibrocystic breast change (FBC) from breast invasive ductal carcinoma (BIDC). We selected 50 patients each with nodular FBC and BIDC, who were admitted to the Affiliated Hospital of Zunyi Medical University from January 2018 to December 2021. Their ultrasonic elastic images and CEUS videos were collected, their ultrasound elastography scores and the ratio of strain rate (SR) of the lesions were determined, and the exported DICOM format videos of CEUS were quantitatively analyzed using VueBox software to obtain quantitative perfusion parameters. The differences between the ultrasound elastography score and SR while comparing nodular FBC and BIDC cases were statistically significant ( p < .05). The sensitivity, specificity, and accuracy of ultrasound elastography scores in the differential diagnoses of nodular FBC and BIDC were 74%, 88%, and 81%, respectively. Additionally, the sensitivity, specificity, and accuracy of SR in the differential diagnosis of nodular FBC and BIDC were 94%, 78%, and 86%, respectively. Statistically significant differences were observed in the CEUS quantitative perfusion parameters PE, AUC (WiAUC, WoAUC, WiWoAUC), and WiPI in both nodular FBC and BIDC according to the VueBox software ( p < .05). The sensitivity, specificity, and accuracy of CEUS quantitative analysis in the differential diagnoses of nodular FBC and BIDC were 66%, 82%, and 74%, respectively. Using the pathological findings as the gold standard, ROC curves were established, and the area under the curve (AUC) of the CEUS quantitative analysis, elasticity score, SR, and ultrasound elastography combined with CEUS quantitative analysis were 0.731, 0.838, and 0.892, as well as 0.945, respectively. Ultrasound elasticity scoring, SR and CEUS quantitative analysis have certain application value for differentiating nodular FBC cases from BIDC; however, ultrasound elasticity imaging combined with CEUS quantitative analysis can help in improving the differential diagnostic efficacy of nodular FBC cases from BIDC.

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Section: Discussionmentioning

confidence: 99%

Application Value of Ultrasound Elastography Combined With Contrast-Enhanced Ultrasound (CEUS) Quantitative Analysis in Differentiation of Nodular Fibrocystic Changes of the Breast From Invasive Ductal Carcinoma

Li,

Wu,

Tian

et al. 2023

Ultrason Imaging

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Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

et al. 2023

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Breast cancer can metastasize to a wide range of organs, but reports about uterine metastases are rare. The current article systematically analyzes 55 patients reported in peer-reviewed literature from 2010–2022 with respect to nine variables, including: [i] age of the patient; [ii] clinical presentation of uterine metastasis; [iii] precise location of metastasis; [iv] primary (breast) cancer histopathology; [v] imaging modality utilized for detection of metastasis; [vi] timing of appearance of metastases: synchronous or metachronous; [vii] immunochemistry markers; [viii] management; and [ix] survival. Uterine metastases may appear in synchronous or metachronous fashion and may be asymptomatic or have symptoms like abnormal vaginal bleeding. Treatment of uterine metastases usually comprises of total abdominal hysterectomy with bilateral salpingo-oophorectomy along with chemotherapy. The long-term prognosis is unclear, but due to the development of metastases in other bodily parts, cases frequently have a poor outcome.

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Diagnostic Pitfalls of Metastatic Lobular Breast Carcinoma to the Endometrium in a Patient on Long-Standing Tamoxifen Therapy

Chew¹,

Lai²,

Ali³

et al. 2022

MJMHS

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Metastatic carcinoma from extragenital sites to the uterus, particularly the endometrium, is rare and usually a sign of advanced disease. It is necessary to differentiate between metastatic and primary tumours since the treatment and prognosis are entirely different. We discuss a case of a 61-year-old woman who presented with postmenopausal bleeding due to metastatic breast cancer to the endometrium. She had been diagnosed with breast cancer and on tamoxifen for six years. This case highlights the possibility of isolated breast cancer metastasis to the endometrium without ovarian involvement and the overlapping histological features due to tamoxifen therapy. Abnormal uterine bleeding in a case of breast cancer should raise the suspicion of metastatic breast disease. The immunohistochemical study is critical to support the microscopic findings in conjunction with clinical history and radiological findings.

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Uterine metastasis from invasive ductal breast carcinoma: A case report with literature review

Cited by 3 publications

References 40 publications

Application Value of Ultrasound Elastography Combined With Contrast-Enhanced Ultrasound (CEUS) Quantitative Analysis in Differentiation of Nodular Fibrocystic Changes of the Breast From Invasive Ductal Carcinoma

Application Value of Ultrasound Elastography Combined With Contrast-Enhanced Ultrasound (CEUS) Quantitative Analysis in Differentiation of Nodular Fibrocystic Changes of the Breast From Invasive Ductal Carcinoma

Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

Diagnostic Pitfalls of Metastatic Lobular Breast Carcinoma to the Endometrium in a Patient on Long-Standing Tamoxifen Therapy

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