Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models

Sojka, Dorothy K.

doi:10.3389/fimmu.2020.00290

Cited by 12 publications

(11 citation statements)

References 73 publications

(89 reference statements)

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“…uNK cell frequency may change through the menstrual cycle or during pregnancy. Sojka et al used Ncr1-iCre-Rosa mt/mG mice containing membrane-bound Td-tomato to track NK cells during pregnancy [ 188 , 195 , 196 , 197 ]. In this mouse, when Cre is expressed, the floxed Td-tomato cassette and the stop codon are removed, and expression of membrane-bound GFP occurs, facilitating the tracking of uNK cells.…”

Section: Uterine Nk Cellsmentioning

confidence: 99%

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

Hashemi

Malarkannan

2020

Cancers

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Natural killer (NK) cells belong to type 1 innate lymphoid cells (ILC1) and are essential in killing infected or transformed cells. NK cells mediate their effector functions using non-clonotypic germ-line-encoded activation receptors. The utilization of non-polymorphic and conserved activating receptors promoted the conceptual dogma that NK cells are homogeneous with limited but focused immune functions. However, emerging studies reveal that NK cells are highly heterogeneous with divergent immune functions. A distinct combination of several activation and inhibitory receptors form a diverse array of NK cell subsets in both humans and mice. Importantly, one of the central factors that determine NK cell heterogeneity and their divergent functions is their tissue residency. Decades of studies provided strong support that NK cells develop in the bone marrow. However, evolving evidence supports the notion that NK cells also develop and differentiate in tissues. Here, we summarize the molecular basis, phenotypic signatures, and functions of tissue-resident NK cells and compare them with conventional NK cells.

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Section: Uterine Nk Cellsmentioning

confidence: 99%

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

Hashemi

Malarkannan

2020

Cancers

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“…Reports of NK cells in innate immune response and memory events have led to a better understanding of NK cells' tissue-specific role in the immune response [2][3][4][5][6][7]. In a similar fashion as tissue macrophages, tissue-resident NK cells (trNK cells) differ in antigen expression and function.…”

Section: Nk Cell Subpopulationsmentioning

confidence: 99%

“…In a similar fashion as tissue macrophages, tissue-resident NK cells (trNK cells) differ in antigen expression and function. Differences have been described for NK cells from skin, liver, adipose tissue, suggesting that trNK cells may be unique depending on the location [6,7]. Most probably, the variance between normal physiological responses, inflammation and remodeling involves trNK cells, macrophages, and the migration of other cell types [6][7][8][9][10][11][12][13].…”

Section: Nk Cell Subpopulationsmentioning

confidence: 99%

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Garmendia

Sanctis

2021

Immuno

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NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions. In the endometrium, NK cell populations vary depending on age, hormones, and inflammation. When pregnancy occurs, tissue-resident NK cells and conventional NK cells are recruited to protect the fetus, a tolerogenic response. On the contrary, in the inflamed endometrium, various inflammatory cells down-regulate NK tolerance and impair embryo implantation. Therefore, NK cells’ pharmacological modulation is difficult to achieve. Several strategies have been used, from progesterone, lipid emulsions to steroids; the success has not been as expected. However, new therapeutic approaches have been proposed to decrease the endometrial inflammatory burden and increase pregnancy success based on understanding NK cell physiology.

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“…The transcriptional factors that instruct the development of trNK cells are different from those of cNK cells. For instance, mice with E4bp4 deficiency lack conventional NK (cNK) cells, but have trNK cells in liver and uterus ( 101 ). In addition, the phenotype markers and necessary factors for the development of trNK cells have been found to display notable tissue-specific properties.…”

Section: Perspectivesmentioning

confidence: 99%

Molecular Regulation of NK Cell Maturation

Wang

2020

Front. Immunol.

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Natural killer (NK) cells are innate lymphocytes specialized in immune surveillance against tumors and infections. To reach their optimal functional status, NK cells must undergo a process of maturation from immature to mature NK cells. Genetically modified mice, as well as in vivo and in vitro NK cell differentiation assays, have begun to reveal the landscape of the regulatory network involved in NK cell maturation, in which a balance of cytokine signaling pathways leads to an optimal coordination of transcription factor activity. An increased understanding of NK cell maturation will greatly promote the development and application of NK cell-based clinical therapy. Thus, in this review, we summarize the dynamics of NK cell maturation, describe recently identified factors involved in the regulation of the NK cell maturation process, including cytokines and transcription factors, and discuss the importance of NK cell maturation in health and disease.

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Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models

Cited by 12 publications

References 73 publications

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Molecular Regulation of NK Cell Maturation

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