Uterine Natural Killer Cells: A Rising Star in Human Pregnancy Regulation

Xie, Min; Li, Yan; Meng, Yizi; Xu, Ping; Yang, Yong‐Guang; Dong, Shuai; He, Jie

doi:10.3389/fimmu.2022.918550

Cited by 28 publications

(24 citation statements)

References 184 publications

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“…uNK cells have a different phenotype from peripheral pNK cells and have a strong secretory capacity. uNK cells are currently thought to have several possible sources and can differentiate into dNK cells by interacting with the metaphase microenvironment ( 47 ). dNK cells are the most important lymphocytes in the metaphase of early and mid pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that dNK cells play an important role in uterine spiral artery remodeling, placental development, and resistance to microbial infections. In normal pregnancy, the maternal-fetal interface is immune tolerant and activated dNK cells play an important role in defending against infection and preventing intra-placental transmission in the presence of pathogenic microorganisms ( 47 ). dNK cells are recruited in large numbers near the uterine spiral arteries and interact with ligands on the surface of trophoblast cells to activate dNK cells to secrete cytokines and angiogenic factors, induce de-differentiation of spiral arterial vascular smooth muscle cells ( 49 ), as well as promote the recruitment and invasive capacity of EVT cells ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

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Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

Wang

Tong

2023

Front. Immunol.

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BackgroundA growing evidence suggests that immune cells play a significant role in the pathogenesis of hypertensive disorders of pregnancy (HDP).Over the past 20 years, several studies have been conducted on the role of immune cells in hypertensive disorders of pregnancy. This study used bibliometric analysis to assess research hotspots and future trends in studies on immune cells in hypertensive disorders of pregnancy.MethodsWe extracted all relevant literature on immune cells and hypertensive disorders of pregnancy from the Web of Science core collection for the period of 2001 to 2021. We used VOS Viewer, CiteSpace, R-bibliometrix and Python for bibliometric analysis.ResultsWe identified 2,388 records published in 593 journals by 9,886 authors from 2,174 universities/institutions in 91 countries/regions. The number of publications tended to increase over time, with the highest number of publications in 2021, up to 205. The USA was the country with the most publications. UNIVERSITY OF MISSISSIPPI was the most influential institution. Lamarca B, Romero R, and Saito S were the most prolific authors. Finally, three research hotspot clusters were identified based on keywords, which reflected the role of immune cells in the development of hypertensive disorders of pregnancy, the current research status,and predicted hot spots for future research.ConclusionsOur study systematically analyzed the role of immune cells in the pathogenesis of hypertensive disorders of pregnancy in the last 20 years. Our results indicated that immune cells, such as T cells, natural killer (NK) cells,and macrophages, and the cytokines released such as TNF-α, IFN-γ in the maternal circulation and at the maternal-fetal interface would influence the development of hypertensive disorders of pregnancy and we need further investigate the role of individual immune cells and translational studies to provide new therapeutic perspectives to mitigate adverse perinatal outcomes due to hypertensive disorders of pregnancy. In conclusion, bibliometric studies provide a general overview of immune cells in the study of hypertensive disorders of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

Wang

Tong

2023

Front. Immunol.

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“…Recurrent EPL is a major concern in human reproduction and the focus of much research due to its complex etiology, poor prognosis, and adverse effects on the physical and mental health of pregnant women [ 3 ]. Immune abnormalities, mainly T cell subsets and related miRNA abnormalities, are known to play a vital role in the occurrence of EPL [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

T Cell Subsets and the Expression of Related MicroRNAs in Patients with Recurrent Early Pregnancy Loss

Yan

Jian

Yang

et al. 2023

Mediators of Inflammation

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This study explored the role of T cell subsets and the expression of related microRNAs in patients with recurrent early pregnancy loss (EPL). Fifty patients with EPL loss between May 2018 and May 2021 were randomly selected as the EPL group, and 50 pregnant women with normal pregnancies or normal delivery outcomes were randomly selected as the control group. The expression levels of T cell subset-related markers and T cell subset-related miRNAs, in addition to the frequencies of T cell subsets, in peripheral blood of the two groups were analyzed. In terms of T cell-related markers, the results showed that the expression levels of the transcriptional regulator TBX-21 (T-bet) and interferon regulatory factor 4 (IRF4) were significantly upregulated in peripheral blood of the patients in the EPL group ( P < 0.05 ), whereas the expression levels of GATA binding protein 3 (GATA3) and glucocorticoid-induced tumor necrosis factor receptor (GITR) were significantly downregulated ( P < 0.05 ). In the EPL group, the expression of mir-106b, mir-93, and mir-25 was upregulated ( 1.51 ± 0.129 , 1.43 ± 0.132 , and 1.73 ± 0.156 , respectively) in regulatory T (Treg) cell-related T cell subsets, whereas the expression of miR-146a and miR-155 was downregulated ( P < 0.05 ). The frequencies of Treg and exhausted T cells in the EPL group were significantly lower than those in the control group ( P < 0.05 ). The cell frequencies of T helper 17 (Th17) cells and exhausted Treg cells in the EPL group were significantly higher than those in the control group ( P < 0.05 ). In conclusion, immune cells and associated miRNA profiles can be used as prognostic biomarkers for the treatment of human reproductive disorders, such as EPL.

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“…Published by Francis Academic Press, UK -9-dNK cells can not only play an immunomodulatory role in the maternal fetal interface [3] , but also play a key role in the regulation of trophoblast invasion and vascular remodeling [4,5] .…”

Section: Introductionmentioning

confidence: 99%

Research progress in the mechanism of action of NK cell-related receptors during recurrent spontaneous abortion

2023

AJMHS

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Recurrent spontaneous abortion (RSA) refers to multiple spontaneous abortions with the same sexual partner; In 2020, Chinese expert consensus suggested that it should be defined as the loss of the embryo or fetus before 28 weeks of gestation with the same sexual partner for two or more times in a row, including the biochemical pregnancy that occurred several times in a row. The pathogenesis of RSA is complex and diverse. At present, the pathogenesis factors have been widely recognized by the industry, including genetic factors, endocrine factors, anatomical abnormalities, infectious factors and immune factors. Among them, the role of immune factors such as T lymphocytes, dendritic cells and natural killer cells (NK) in the occurrence and development of RSA has attracted wide attention, especially NK cells. NK cells are an important part of human immune system. The specific surface molecules of Decidual natural killer cell (dNK) play an immunomodulatory role in the invasion of trophoblast cells and the remodeling of uterine spiral artery during pregnancy, which is particularly important in the early gestation period. The function of dNK cells is tightly regulated by a balance between activation and inhibition signals transmitted by the various family of receptors (NK cell receptors, NKRS) that DNK cells express. In this paper, the existing research progress of decidual NK cells on the mechanism of its receptors in the process of recurrent spontaneous abortion will be reviewed as follows.

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Uterine Natural Killer Cells: A Rising Star in Human Pregnancy Regulation

Cited by 28 publications

References 184 publications

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

Global trends in research of immune cells associated with hypertensive disorders of pregnancy: A 20-year bibliometric analyses (from 2001 to 2021)

T Cell Subsets and the Expression of Related MicroRNAs in Patients with Recurrent Early Pregnancy Loss

Research progress in the mechanism of action of NK cell-related receptors during recurrent spontaneous abortion

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